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A complete time-parameterized statistical model quantifying the divergent evolution of protein structures in terms of the patterns of conservation of their secondary structures is inferred from a large collection of protein 3D structure…

Quantitative Methods · Quantitative Biology 2023-08-15 Sandun Rajapaksa , Lloyd Allison , Peter J. Stuckey , Maria Garcia de la Banda , Arun S. Konagurthu

Proteins are macromolecules that perform essential functions in all living organisms. Designing novel proteins with specific structures and desired functions has been a long-standing challenge in the field of bioengineering. Existing…

Biomolecules · Quantitative Biology 2023-03-03 Chence Shi , Chuanrui Wang , Jiarui Lu , Bozitao Zhong , Jian Tang

Despite a lot of research efforts devoted in recent years, how to efficiently learn long-term dependencies from sequences still remains a pretty challenging task. As one of the key models for sequence learning, recurrent neural network…

Computer Vision and Pattern Recognition · Computer Science 2017-03-21 Yemin Shi , Yonghong Tian , Yaowei Wang , Tiejun Huang

We describe recurrent neural networks (RNNs), which have attracted great attention on sequential tasks, such as handwriting recognition, speech recognition and image to text. However, compared to general feedforward neural networks, RNNs…

Machine Learning · Computer Science 2018-01-16 Gang Chen

Recurrent neural networks (RNN) are simple dynamical systems whose computational power has been attributed to their short-term memory. Short-term memory of RNNs has been previously studied analytically only for the case of orthogonal…

Neural and Evolutionary Computing · Computer Science 2016-04-26 Alireza Goudarzi , Sarah Marzen , Peter Banda , Guy Feldman , Christof Teuscher , Darko Stefanovic

Despite an explosion in the number of experimentally determined, atomically detailed structures of biomolecules, many critical tasks in structural biology remain data-limited. Whether performance in such tasks can be improved by using large…

Biomolecules · Quantitative Biology 2019-12-30 Raphael J. L. Townshend , Rishi Bedi , Patricia A. Suriana , Ron O. Dror

Long short-term memory (LSTM) is a robust recurrent neural network architecture for learning spatiotemporal sequential data. However, it requires significant computational power for learning and implementing from both software and hardware…

Machine Learning · Computer Science 2022-10-26 Nelly Elsayed , Zag ElSayed , Anthony S. Maida

The prediction of protein secondary and tertiary structures from the primary amino acid sequence is both an incredibly important and incredibly difficult problem. Accurate prediction of a protein's native structure can provide critical…

Biological Physics · Physics 2020-07-14 Sean Mullane

After the tremendous development of neural networks trained by backpropagation, it is a good time to develop other algorithms for training neural networks to gain more insights into networks. In this paper, we propose a new algorithm for…

Machine Learning · Computer Science 2020-07-01 Benyamin Ghojogh , Fakhri Karray , Mark Crowley

Based on the predictive coding theory in neuroscience, we designed a bi-directional and recurrent neural net, namely deep predictive coding networks (PCN). It has feedforward, feedback, and recurrent connections. Feedback connections from a…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Haiguang Wen , Kuan Han , Junxing Shi , Yizhen Zhang , Eugenio Culurciello , Zhongming Liu

This paper investigates two different neural architectures for the task of relation classification: convolutional neural networks and recurrent neural networks. For both models, we demonstrate the effect of different architectural choices.…

Computation and Language · Computer Science 2016-05-25 Ngoc Thang Vu , Heike Adel , Pankaj Gupta , Hinrich Schütze

In the recent publication (arxiv:2007.08063v2 [cs.LG]) a fast prediction algorithm for a single recurrent network (RN) was suggested. In this manuscript we generalize this approach to a chain of RNs and show that it can be implemented in…

Dynamical Systems · Mathematics 2020-10-06 Boris Rubinstein

Multivariate techniques based on engineered features have found wide adoption in the identification of jets resulting from hadronic top decays at the Large Hadron Collider (LHC). Recent Deep Learning developments in this area include the…

High Energy Physics - Experiment · Physics 2017-11-27 Shannon Egan , Wojciech Fedorko , Alison Lister , Jannicke Pearkes , Colin Gay

Recurrent neural networks (RNNs) have recently achieved remarkable successes in a number of applications. However, the huge sizes and computational burden of these models make it difficult for their deployment on edge devices. A practically…

Machine Learning · Computer Science 2019-12-10 Liangjian Wen , Xuanyang Zhang , Haoli Bai , Zenglin Xu

Protein structure prediction is one of the most important problems in computational biology. The most successful computational approach, also called template-based modeling, identifies templates with solved crystal structures for the query…

Biomolecules · Quantitative Biology 2013-06-20 Jian Peng

Fine-grained visual categorization (FGVC) is an important but challenging task due to high intra-class variances and low inter-class variances caused by deformation, occlusion, illumination, etc. An attention convolutional binary neural…

Computer Vision and Pattern Recognition · Computer Science 2020-03-17 Ruyi Ji , Longyin Wen , Libo Zhang , Dawei Du , Yanjun Wu , Chen Zhao , Xianglong Liu , Feiyue Huang

In this paper, we present an adaptation of the sequence-to-sequence model for structured output prediction in vision tasks. In this model the output variables for a given input are predicted sequentially using neural networks. The…

Computer Vision and Pattern Recognition · Computer Science 2016-10-25 Georgia Gkioxari , Alexander Toshev , Navdeep Jaitly

Proteins play a pivotal role in biological systems. The use of machine learning algorithms for protein classification can assist and even guide biological experiments, offering crucial insights for biotechnological applications. We…

Quantitative Methods · Quantitative Biology 2024-10-24 Yizheng Wang , Yixiao Zhai , Yijie Ding , Quan Zou

Sequential activation of neurons is a common feature of network activity during a variety of behaviors, including working memory and decision making. Previous network models for sequences and memory emphasized specialized architectures in…

Neurons and Cognition · Quantitative Biology 2016-03-16 Kanaka Rajan , Christopher D Harvey , David W Tank

Applying machine learning models to meteorological data brings many opportunities to the Geosciences field, such as predicting future weather conditions more accurately. In recent years, modeling meteorological data with deep neural…

Machine Learning · Computer Science 2020-11-11 Rafaela Castro , Yania M. Souto , Eduardo Ogasawara , Fabio Porto , Eduardo Bezerra