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The metabolic activity of microbes has played an essential role in the evolution and persistence of life on Earth. Microbial metabolism plays a primary role in the flow of carbon, nitrogen and other elements through the biosphere on a…

Populations and Evolution · Quantitative Biology 2022-01-20 Chandana Gopalakrishnappa , Karna Gowda , Kaumudi Prabhakara , Seppe Kuehn

In microbiome studies, it is often of great interest to identify clusters or partitions of microbiome profiles within a study population and to characterize the distinctive attributes of each resulting microbial community. While raw counts…

Methodology · Statistics 2025-08-18 Zhongmao Liu , Xiaohui Yin , Yanjiao Zhou , Gen Li , Kun Chen

Surveys of microbial biodiversity such as the Earth Microbiome Project (EMP) and the Human Microbiome Project (HMP) have revealed robust ecological patterns across different environments. A major goal in ecology is to leverage these…

Populations and Evolution · Quantitative Biology 2020-03-05 Robert Marsland , Wenping Cui , Pankaj Mehta

Due to the recent advances in high-throughput sequencing technologies, it becomes possible to directly analyze microbial communities in the human body and in the environment. Knowledge of how microbes interact with each other and form…

Quantitative Methods · Quantitative Biology 2018-07-24 Chieh Lo , Radu Marculescu

Life pattern clustering is essential for abstracting the groups' characteristics of daily mobility patterns and activity regularity. Based on millions of GPS records, this paper proposed a framework on the life pattern clustering which can…

Computers and Society · Computer Science 2021-04-27 Wenjing Li , Haoran Zhang , Jinyu Chen , Peiran Li , Yuhao Yao , Mariko Shibasaki , Xuan Song , Ryosuke Shibasaki

Microbiome research has immense potential for unlocking insights into human health and disease. A common goal in human microbiome research is identifying subgroups of individuals with similar microbial composition that may be linked to…

Methodology · Statistics 2025-08-21 Suppapat Korsurat , Matthew D. Koslovsky

The human body consists of microbiomes associated with the development and prevention of several diseases. These microbial organisms form several complex interactions that are informative to the scientific community for explaining disease…

Methodology · Statistics 2024-04-16 Tejasv Bedi , Bencong Zhu , Michael L. Neugent , Kevin C. Lutz , Nicole J. De Nisco , Qiwei Li

Microbial communities assemble through a complex set of interactions between microbes and their environment, and the resulting metabolic impact on the host ecosystem can be profound. Microbial activity is known to impact human health, plant…

Quantitative Methods · Quantitative Biology 2023-11-09 James D. Brunner , Laverne A. Gallegos-Graves , Marie E. Kroeger

Microbiomes, which are collections of interacting microbes in an environment, often substantially impact the environmental patches or living hosts that they occupy. In microbiome models, it is important to consider both the local dynamics…

Dynamical Systems · Mathematics 2025-07-18 Michael Johnson , Mason A. Porter

Human behavior modeling deals with learning and understanding behavior patterns inherent in humans' daily routines. Existing pattern mining techniques either assume human dynamics is strictly periodic, or require the number of modes as…

Machine Learning · Computer Science 2021-10-26 Rohan Kabra , Divya Saxena , Dhaval Patel , Jiannong Cao

Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to the environment. Current methods for analysis of microbial communities are typically based on taxonomic…

Genomics · Quantitative Biology 2015-12-02 Ehsaneddin Asgari , Kiavash Garakani , Mohammad R. K Mofrad

Dynamic networks, especially those representing social networks, undergo constant evolution of their community structure over time. Nodes can migrate between different communities, communities can split into multiple new communities,…

Social and Information Networks · Computer Science 2017-08-29 Timothy La Fond , Geoffrey Sanders , Christine Klymko , Van Emden Henson

High-throughput sequencing technology provides unprecedented opportunities to quantitatively explore human gut microbiome and its relation to diseases. Microbiome data are compositional, sparse, noisy, and heterogeneous, which pose serious…

Methodology · Statistics 2020-10-12 Fangting Zhou , Kejun He , Qiwei Li , Robert S. Chapkin , Yang Ni

From soil to the gut, communities composed of thousands of microbes perform functions such as carbon sequestration and immune system regulation. Here, we introduce a data-driven approach that explains how community function can be traced to…

Biological Physics · Physics 2026-03-05 Matthew S Schmitt , Kiseok Lee , Freddy Bunbury , Joseph A Landsittel , Vincenzo Vitelli , Seppe Kuehn

There is a growing awareness of the important roles that microbial communities play in complex biological processes. Modern investigation of these often uses next generation sequencing of metagenomic samples to determine community…

Applications · Statistics 2018-01-25 Adrian Dobra , Camilo Valdes , Dragana Ajdic , Bertrand Clarke , Jennifer Clarke

Microbes can affect processes from food production to human health. Such microbes are not isolated, but rather interact with each other and establish connections with their living environments. Understanding these interactions is essential…

Applications · Statistics 2021-09-07 Liang Chen , Qiuyan He , Hui Wan , Shun He , Minghua Deng

The microbiome constitutes a complex microbial ecology of interacting components that regulates important pathways in the host. Measurements of microbial abundances are key to learning the intricate network of interactions amongst microbes.…

Methodology · Statistics 2024-06-17 Veronica Vinciotti , Ernst Wit , Francisco Richter

The increasing volumes of data produced by high-throughput instruments coupled with advanced computational infrastructures for scientific computing have enabled what is often called a {\em Fourth Paradigm} for scientific research based on…

The introduction of non-native organisms into complex microbiome communities holds enormous potential to benefit society. However, microbiome engineering faces several challenges including successful establishment of the organism into the…

Urban structure detection is a basic task in urban geography. Clustering is a core technology to detect the patterns of urban spatial structure, urban functional region, and so on. In big data era, diverse urban sensing datasets recording…

Social and Information Networks · Computer Science 2017-07-13 Xin Lin , Haifeng Li , Yan Zhang , Lei Gao , Ling Zhao , Min Deng
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