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Identifying prognostic factors for disease progression is a cornerstone of medical research. Repeated assessments of a marker outcome are often used to evaluate disease progression, and the primary research question is to identify factors…

Computation · Statistics 2022-10-24 Brian Kwan , Lin Liu , David Strong , H. Irene Su , Loki Natarajan

Background: Multiple Sclerosis (MS), an autoimmune disease affecting millions worldwide, is characterized by its variable course, in which some patients will experience a more benign disease course and others a more active one, with the…

Applications · Statistics 2024-12-12 Uma Sthanu , Gary Cutter PhD

This work aims at providing a new model for time series classification based on learning from just one example. We assume that time series can be well characterized as a parametric random process, a sort of Hidden semi-Markov Model…

Machine Learning · Statistics 2022-11-18 Adrián Pérez Herrero , Paulo Félix Lamas , Jesús María Rodríguez Presedo

Identifying dynamical system (DS) is a vital task in science and engineering. Traditional methods require numerous calls to the DS solver, rendering likelihood-based or least-squares inference frameworks impractical. For efficient parameter…

Computation · Statistics 2024-09-19 Ying Zhou , Jinglai Li , Xiang Zhou , Hongqiao Wang

Mixture models are a fundamental tool in applied statistics and machine learning for treating data taken from multiple subpopulations. The current practice for estimating the parameters of such models relies on local search heuristics…

Machine Learning · Computer Science 2012-09-07 Animashree Anandkumar , Daniel Hsu , Sham M. Kakade

Partially Observable Markov Decision Processes (POMDPs) model decision making under uncertainty. While there are many approaches to approximately solving POMDPs, we aim to address the problem of learning such models. In particular, we are…

Artificial Intelligence · Computer Science 2025-05-13 Aidan Curtis , Hao Tang , Thiago Veloso , Kevin Ellis , Joshua Tenenbaum , Tomás Lozano-Pérez , Leslie Pack Kaelbling

The estimation problem in a high regression model with structured sparsity is investigated. An algorithm using a two steps block thresholding procedure called GR-LOL is provided. Convergence rates are produced: they depend on simple…

Statistics Theory · Mathematics 2012-07-10 Mathilde Mougeot , Dominique Picard , Karine Tribouley

Hidden Markov jump processes are an attractive approach for modeling clinical disease progression data because they are explainable and capable of handling both irregularly sampled and noisy data. Most applications in this context consider…

Methodology · Statistics 2019-10-15 Rui Meng , Soper Braden , Jan Nygard , Mari Nygrad , Herbert Lee

Generalized linear model or GLM constitutes a large class of models and essentially extends the ordinary linear regression by connecting the mean of the response variable with the covariate through appropriate link functions. On the other…

Methodology · Statistics 2026-02-03 Mayukh Choudhury , Debraj Das

Many programs evaluated in observational studies incorporate a sequential structure, where individuals may be assigned to various programs over time. While this complexity is often simplified by analyzing programs at single points in time,…

Econometrics · Economics 2025-06-16 Fabian Muny

We propose a generic Markov Chain Monte Carlo (MCMC) algorithm to speed up computations for datasets with many observations. A key feature of our approach is the use of the highly efficient difference estimator from the survey sampling…

Methodology · Statistics 2017-08-03 Matias Quiroz , Mattias Villani , Robert Kohn

There is a lack of methodological results for continuous time change detection due to the challenges of noninformative prior specification and efficient posterior inference in this setting. Most methodologies to date assume data are…

Methodology · Statistics 2025-04-28 Dan Cunha , Mark Friedl , Luis Carvalho

We propose an online algorithm for tracking a multidimensional time-varying parameter of a time series, which is also allowed to be a predictable process with respect to the underlying time series. The algorithm is driven by a gain…

Statistics Theory · Mathematics 2013-11-15 Eduard Belitser , Paulo Serra

Marked Temporal Point Process (MTPP) has been well studied to model the event distribution in marked event streams, which can be used to predict the mark and arrival time of the next event. However, existing studies overlook that the…

Machine Learning · Computer Science 2025-10-27 Sishun Liu , Ke Deng , Yongli Ren , Yan Wang , Xiuzhen Zhang

The autoregressive (AR) model is a widely used model to understand time series data. Traditionally, the innovation noise of the AR is modeled as Gaussian. However, many time series applications, for example, financial time series data, are…

Applications · Statistics 2019-03-27 Junyan Liu , Sandeep Kumar , Daniel P. Palomar

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

Methodology · Statistics 2023-01-23 Lars Lau Raket

Markov models are often used to capture the temporal patterns of sequential data for statistical learning applications. While the Hidden Markov modeling-based learning mechanisms are well studied in literature, we analyze a…

Machine Learning · Statistics 2021-03-25 Devesh K. Jha

The Linear Ballistic Accumulator (Brown & Heathcote, 2008) model is used as a measurement tool to answer questions about applied psychology. The analyses based on this model depend upon the model selected and its estimated parameters.…

Methodology · Statistics 2020-03-03 David Gunawan , Guy E. Hawkins , Minh-Ngoc Tran , Robert Kohn , Scott Brown

The randomized projection (RP) method is a simple iterative scheme for solving linear feasibility problems and has recently gained popularity due to its speed and low memory requirement. This paper develops an accelerated variant of the…

Optimization and Control · Mathematics 2022-11-21 Lin Zhu , Yuan Lei , Jiaxin Xie

To analyze and project age-specific mortality or morbidity rates age-period-cohort (APC) models are very popular. Bayesian approaches facilitate estimation and improve predictions by assigning smoothing priors to age, period and cohort…

Applications · Statistics 2012-03-21 Andrea Riebler , Leonhard Held , Håvard Rue