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In clinical practice and biomedical research, measurements are often collected sparsely and irregularly in time while the data acquisition is expensive and inconvenient. Examples include measurements of spine bone mineral density, cancer…

Machine Learning · Statistics 2021-08-05 Łukasz Kidziński , Trevor Hastie

Due to the ease of modern data collection, applied statisticians often have access to a large set of covariates that they wish to relate to some observed outcome. Generalized linear models (GLMs) offer a particularly interpretable framework…

Computation · Statistics 2019-05-21 Brian L. Trippe , Jonathan H. Huggins , Raj Agrawal , Tamara Broderick

Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of individuals, combining questionnaires with clinical, genetic,…

Quantitative Methods · Quantitative Biology 2019-03-19 Qifan Yang , Gennady V. Roshchupkin , Wiro J. Niessen , Sarah E. Medland , Alyssa H. Zhu , Paul M. Thompson , Neda Jahanshad

This study introduces an integrated framework for predictive causal inference designed to overcome limitations inherent in conventional single model approaches. Specifically, we combine a Hidden Markov Model (HMM) for spatial health state…

Methodology · Statistics 2025-10-31 Byunghee Lee , Hye Yeon Sin , Joonsung Kang

In the last few decades, the study of ordinal data in which the variable of interest is not exactly observed but only known to be in a specific ordinal category has become important. In Psychometrics such variables are analysed under the…

Econometrics · Economics 2025-01-22 Bernard M. S. van Praag , J. Peter Hop , William H. Greene

Time-homogeneous Markov chains are often used as disease progression models in studies of cost-effectiveness and optimal decision-making. Maximum likelihood estimation of these models can be challenging when data are collected at a time…

Methodology · Statistics 2022-09-26 Duncan Ermini Leaf

Spatial generalized linear mixed models (SGLMMs) are popular and flexible models for non-Gaussian spatial data. They are useful for spatial interpolations as well as for fitting regression models that account for spatial dependence, and are…

Methodology · Statistics 2021-10-26 Yawen Guan , Murali Haran

Predicting relative risk (RR) of spatial clusters is a complex task in public health that can be achieved through various statistical and machine-learning methods for different time intervals. However, high-resolution longitudinal data is…

Methodology · Statistics 2025-12-23 Lyza Iamrache , Kamel Rekab , Majid Bani-Yagoub , Julia Pluta , Abdelghani Mehailia

We study a class of multi-stage stochastic programs, which incorporate modeling features from Markov decision processes (MDPs). This class includes structured MDPs with continuous action and state spaces. We extend policy graphs to include…

Machine Learning · Computer Science 2026-04-09 David P. Morton , Oscar Dowson , Bernardo K. Pagnoncelli

In this paper we consider the problem of parameter inference for Markov jump process (MJP) representations of stochastic kinetic models. Since transition probabilities are intractable for most processes of interest yet forward simulation is…

Computation · Statistics 2014-09-16 Andrew Golightly , Darren J. Wilkinson

Many real-world problems encountered in several disciplines deal with the modeling of time-series containing different underlying dynamical regimes, for which probabilistic approaches are very often employed. In this paper we describe…

Machine Learning · Statistics 2015-03-19 Silvia Chiappa

Nowadays insurers have to account for potentially complex dependence between risks. In the field of loss reserving, there are many parametric and non-parametric models attempting to capture dependence between business lines. One common…

Methodology · Statistics 2024-10-22 Andrew Fleck , Edward Furman , Yang Shen

Inference in hidden Markov model has been challenging in terms of scalability due to dependencies in the observation data. In this paper, we utilize the inherent memory decay in hidden Markov models, such that the forward and backward…

Machine Learning · Statistics 2025-01-14 Felix X. -F. Ye , Yi-an Ma , Hong Qian

Prediction of diabetes and its various complications has been studied in a number of settings, but a comprehensive overview of problem setting for diabetes prediction and care management has not been addressed in the literature. In this…

Machine Learning · Computer Science 2021-04-30 Aloysius Lim , Ashish Singh , Jody Chiam , Carly Eckert , Vikas Kumar , Muhammad Aurangzeb Ahmad , Ankur Teredesai

Current approaches to fair valuation in insurance often follow a two-step approach, combining quadratic hedging with application of a risk measure on the residual liability, to obtain a cost-of-capital margin. In such approaches, the…

Risk Management · Quantitative Finance 2023-06-22 Karim Barigou , Valeria Bignozzi , Andreas Tsanakas

Data on functional disability are of widespread policy interest in the United States, especially with respect to planning for Medicare and Social Security for a growing population of elderly adults. We consider an extract of functional…

Applications · Statistics 2009-09-29 Elena A. Erosheva , Stephen E. Fienberg , Cyrille Joutard

The Hidden Markov Model (HMM) can predict the future value of a time series based on its current and previous values, making it a powerful algorithm for handling various types of time series. Numerous studies have explored the improvement…

Machine Learning · Computer Science 2024-02-28 YeXin Huang

We consider likelihood-based two-step estimation of latent variable models, in which just the measurement model is estimated in the first step and the measurement parameters are then fixed at their estimated values in the second step where…

Methodology · Statistics 2025-08-26 Jouni Kuha , Zsuzsa Bakk

The primary objective of this scholarly work is to develop two estimation procedures - maximum likelihood estimator (MLE) and method of trimmed moments (MTM) - for the mean and variance of lognormal insurance payment severity data sets…

Methodology · Statistics 2024-02-22 Chudamani Poudyal

In this paper, we propose an algorithm for estimating the parameters of a time-homogeneous hidden Markov model from aggregate observations. This problem arises when only the population level counts of the number of individuals at each time…

Machine Learning · Computer Science 2021-11-16 Rahul Singh , Qinsheng Zhang , Yongxin Chen
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