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Genome-scale gene networks contain regulatory genes called hubs that have many interaction partners. These genes usually play an essential role in gene regulation and cellular processes. Despite recent advancements in high-throughput…

Quantitative Methods · Quantitative Biology 2017-10-06 Nurgazy Sulaimanov , Sunil Kumar , Frédéric Burdet , Mark Ibberson , Marco Pagni , Heinz Koeppl

We propose the Gaussian Gated Linear Network (G-GLN), an extension to the recently proposed GLN family of deep neural networks. Instead of using backpropagation to learn features, GLNs have a distributed and local credit assignment…

Machine Learning · Computer Science 2020-10-22 David Budden , Adam Marblestone , Eren Sezener , Tor Lattimore , Greg Wayne , Joel Veness

De novo DNA assembly is a fundamental task in Bioinformatics, and finding Eulerian paths on de Bruijn graphs is one of the dominant approaches to it. In most of the cases, there may be no one order for the de Bruijn graph that works well…

Data Structures and Algorithms · Computer Science 2018-05-15 Diego Díaz-Domínguez , Djamal Belazzougui , Travis Gagie , Veli Mäkinen , Gonzalo Navarro , Simon J. Puglisi

A popular approach to protein design is to combine a generative model with a discriminative model for conditional sampling. The generative model samples plausible sequences while the discriminative model guides a search for sequences with…

Despite superior performance on many computer vision tasks, deep convolution neural networks are well known to be compressed on devices that have resource constraints. Most existing network pruning methods require laborious human efforts…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Xiawu Zheng , Yuexiao Ma , Teng Xi , Gang Zhang , Errui Ding , Yuchao Li , Jie Chen , Yonghong Tian , Rongrong Ji

One of the most computationally intensive tasks in computational biology is de novo genome assembly, the decoding of the sequence of an unknown genome from redundant and erroneous short sequences. A common assembly paradigm identifies…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-10-21 Giulia Guidi , Oguz Selvitopi , Marquita Ellis , Leonid Oliker , Katherine Yelick , Aydin Buluc

Graph condensation reduces the size of large graphs while preserving performance, addressing the scalability challenges of Graph Neural Networks caused by computational inefficiencies on large datasets. Existing methods often rely on…

Machine Learning · Computer Science 2025-10-10 Lin Wang , Qing Li

DNA based storage systems received attention by many researchers. This includes archival and re-writable random access DNA based storage systems. In this work, we have developed an efficient technique to encode the data into DNA sequence by…

Information Theory · Computer Science 2016-04-25 Dixita Limbachiya , Vijay Dhameliya , Madhav Khakhar , Manish K Gupta

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

Mapping data from and/or onto a known family of distributions has become an important topic in machine learning and data analysis. Deep generative models (e.g., generative adversarial networks ) have been used effectively to match known and…

Machine Learning · Computer Science 2020-10-30 Surojit Saha , Shireen Elhabian , Ross T. Whitaker

Graph generation has emerged as a crucial task in machine learning, with significant challenges in generating graphs that accurately reflect specific properties. Existing methods often fall short in efficiently addressing this need as they…

In this paper, we propose {\em distributed network compression via memory}. We consider two spatially separated sources with correlated unknown source parameters. We wish to study the universal compression of a sequence of length $n$ from…

Information Theory · Computer Science 2012-10-09 Ahmad Beirami , Faramarz Fekri

Genome assembly from the high-throughput sequencing (HTS) reads is a fundamental yet challenging computational problem. An intrinsic challenge is the uncertainty caused by the widespread repetitive elements. Here we get around the…

Genomics · Quantitative Biology 2016-09-13 Anqi Wang , Zheng Li , Zhanyu Wang , Lei M. Li

In this paper, we consider recommender systems with side information in the form of graphs. Existing collaborative filtering algorithms mainly utilize only immediate neighborhood information and have a hard time taking advantage of deeper…

Machine Learning · Computer Science 2019-05-30 Liwei Wu , Hsiang-Fu Yu , Nikhil Rao , James Sharpnack , Cho-Jui Hsieh

Deep learning's success has led to larger and larger models to handle more and more complex tasks; trained models can contain millions of parameters. These large models are compute- and memory-intensive, which makes it a challenge to deploy…

Machine Learning · Computer Science 2023-05-19 Chong Yu , Jeff Pool

Huffman compression is a statistical, lossless, data compression algorithm that compresses data by assigning variable length codes to symbols, with the more frequently appearing symbols given shorter codes than the less. This work is a…

Information Theory · Computer Science 2011-07-11 R. L. Cloud , M. L. Curry , H. L. Ward , A. Skjellum , P. Bangalore

With the reduction of sequencing costs and the pervasiveness of computing devices, genomic data collection is continually growing. However, data collection is highly fragmented and the data is still siloed across different repositories.…

Cryptography and Security · Computer Science 2022-03-14 Leonard Dervishi , Xinyue Wang , Wentao Li , Anisa Halimi , Jaideep Vaidya , Xiaoqian Jiang , Erman Ayday

The goal in thinning is to summarize a dataset using a small set of representative points. Remarkably, sub-Gaussian thinning algorithms like Kernel Halving and Compress can match the quality of uniform subsampling while substantially…

Machine Learning · Statistics 2026-03-03 Annabelle Michael Carrell , Albert Gong , Abhishek Shetty , Raaz Dwivedi , Lester Mackey

The application of machine learning(ML) and genetic programming(GP) to the image compression domain has produced promising results in many cases. The need for compression arises due to the exorbitant size of data shared on the internet.…

Neural and Evolutionary Computing · Computer Science 2021-02-18 Maha Mohammed Khan

We propose a new paradigm for encoding the geometry of point cloud sequences, where the convolutional neural network (CNN) which estimates the encoding distributions is optimized on several frames of the sequence to be compressed. We adopt…

Computer Vision and Pattern Recognition · Computer Science 2022-06-06 Emre Can Kaya , Ioan Tabus
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