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Molecular motors and other complex nonequilibrium systems are controlled by large sets of design parameters, and optimizing those parameters requires computing sensitivities -- derivatives of dynamical observables with respect to the…

Statistical Mechanics · Physics 2026-05-12 John Strahan , Todd R. Gingrich

We consider statistical inference for a class of dynamic mixed-effect models described by stochastic differential equations whose drift and diffusion coefficients simultaneously depend on fixed- and random-effect parameters. Assuming that…

Statistics Theory · Mathematics 2025-12-30 Maud Delattre , Hiroki Masuda

Motivated by networked systems in random environment and controlled hybrid stochastic dynamic systems, this work focuses on modeling and analysis of a class of switching diffusions consisting of continuous and discrete components. Novel…

Probability · Mathematics 2017-06-19 Dang H. Nguyen , George Yin

Change point detection has become an important part of the analysis of the single-particle tracking data, as it allows one to identify moments, in which the motion patterns of observed particles undergo significant changes. The segmentation…

Quantitative Methods · Quantitative Biology 2025-06-23 Jakub Malinowski , Marcin Kostrzewa , Michał Balcerek , Weronika Tomczuk , Janusz Szwabiński

We introduce a path sampling method for obtaining statistical properties of an arbitrary stochastic dynamics. The method works by decomposing a trajectory in time, estimating the probability of satisfying a progress constraint, modifying…

Statistical Mechanics · Physics 2015-06-04 Nicholas Guttenberg , Aaron R. Dinner , Jonathan Weare

Recent advances in denoising diffusion probabilistic models have shown great success in image synthesis tasks. While there are already works exploring the potential of this powerful tool in image semantic segmentation, its application in…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Xinrong Hu , Yu-Jen Chen , Tsung-Yi Ho , Yiyu Shi

We propose a method for the accurate estimation of rare event or failure probabilities for expensive-to-evaluate numerical models in high dimensions. The proposed approach combines ideas from large deviation theory and adaptive importance…

Computation · Statistics 2023-03-28 Shanyin Tong , Georg Stadler

Rare event simulation and estimation for systems in equilibrium are among the most challenging topics in molecular dynamics. As was shown by Jarzynski and others, nonequilibrium forcing can theoretically be used to obtain equilibrium rare…

Optimization and Control · Mathematics 2015-06-11 Carsten Hartmann , Christof Schütte

The development of enhanced sampling methods has greatly extended the scope of atomistic simulations, allowing long-time phenomena to be studied with accessible computational resources. Many such methods rely on the identification of an…

Computational Physics · Physics 2022-06-08 Luigi Bonati , GiovanniMaria Piccini , Michele Parrinello

Estimating parameters of a diffusion process given continuous-time observations of the process via maximum likelihood approaches or, online, via stochastic gradient descent or Kalman filter formulations constitutes a well-established…

Methodology · Statistics 2025-03-17 Jan Albrecht , Sebastian Reich

Calculating transition probabilities between different states of multistable climate tipping systems is computationally challenging in high-dimensional models. Targeted algorithms, such as the Trajectory-Adaptive Multilevel Splitting (TAMS)…

Atmospheric and Oceanic Physics · Physics 2026-03-24 Lucas Esclapez , Valérian Jacques-Dumas , Reyk Börner , Laurent Soucasse , Henk A. Dijkstra

A scattering event in a quantum field theory is a coherent superposition of all processes consistent with its symmetries and kinematics. While real-time simulations have progressed toward resolving individual channels, existing approaches…

Quantum Physics · Physics 2026-05-21 Nikita A. Zemlevskiy

We consider the superposition of symmetric simple exclusion dynamics speeded-up in time, with spin-flip dynamics in a one-dimensional interval with periodic boundary conditions. We show that the mixing time has an exponential lower bound in…

Probability · Mathematics 2021-05-28 Kenkichi Tsunoda

For statistics of rare events in systems obeying a large-deviation principle, the rate function is a key quantity. When numerically estimating the rate function one is always restricted to finite system sizes. Thus, if the interest is in…

Data Analysis, Statistics and Probability · Physics 2024-12-06 Peter Werner , Alexander K. Hartmann

Estimating the likelihood, timing, and nature of events is a major goal of modeling stochastic dynamical systems. When the event is rare in comparison with the timescales of simulation and/or measurement needed to resolve the elemental…

Computational Physics · Physics 2023-06-14 John Strahan , Justin Finkel , Aaron R. Dinner , Jonathan Weare

Diffusion models achieve impressive performance in high-fidelity image generation but often struggle with rare concepts that appear infrequently in the training distribution. Prior work attempts to address this issue by prompt switching,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Bo-Kai Ruan , Zi-Xiang Ni , Bo-Lun Huang , Teng-Fang Hsiao , Hong-Han Shuai

Considering the issue of estimating small probabilities p, ie. measuring a rare domain F = {x | g(x) > q} with respect to the distribution of a random vector X, Multilevel Splitting strategies (also called Subset Simulation) aim at writing…

Computation · Statistics 2015-09-10 Clément Walter

The ability to detect and classify rare occurrences in images has important applications - for example, counting rare and endangered species when studying biodiversity, or detecting infrequent traffic scenarios that pose a danger to…

Computer Vision and Pattern Recognition · Computer Science 2019-05-15 Sara Beery , Yang Liu , Dan Morris , Jim Piavis , Ashish Kapoor , Markus Meister , Neel Joshi , Pietro Perona

The estimation of the probability of rare events is an important task in reliability and risk assessment. We consider failure events that are expressed in terms of a limit-state function, which depends on the solution of a partial…

Numerical Analysis · Mathematics 2021-06-21 Fabian Wagner , Jonas Latz , Iason Papaioannou , Elisabeth Ullmann

In this paper, we focus on numerical approximations of Piecewise Diffusion Markov Processes (PDifMPs), particularly when the explicit flow maps are unavailable. Our approach is based on the thinning method for modelling the jump mechanism…

Numerical Analysis · Mathematics 2024-08-23 Evelyn Buckwar , Amira Meddah