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In this paper, we consider a compartmental SIRS epidemic model with asymptomatic infection and seasonal succession, which is a periodic discontinuous differential system. The basic reproduction number $\mathcal{R}_0$ is defined and valuated…

Dynamical Systems · Mathematics 2017-08-15 Yilei Tang , Dongmei Xiao , Weinian Zhang , Di Zhu

We develop a stochastic framework for viral population dynamics at the cellular level that explicitly incorporates the replication cycle with random stage durations. The model is formulated as a structured birth-death process coupled with a…

Populations and Evolution · Quantitative Biology 2026-05-13 Seong Jun Park

We study a stochastic process describing the onset of spreading dynamics of an epidemic in a population composed by individuals of three classes: susceptible (S), infected (I), and recovered (R). The stochastic process is defined by local…

Statistical Mechanics · Physics 2015-05-13 David R. de Souza , Tânia Tomé

In this paper we consider a model for the spread of a stochastic SIR (Susceptible $\to$ Infectious $\to$ Recovered) epidemic on a network of individuals described by a random intersection graph. Individuals belong to a random number of…

Probability · Mathematics 2014-04-29 Frank G. Ball , David J. Sirl , Pieter Trapman

We consider multiple diseases spreading in a static Configuration Model network. We make standard assumptions that infection transmits from neighbor to neighbor at a disease-specific rate and infected individuals recover at a…

Populations and Evolution · Quantitative Biology 2015-06-11 Joel C. Miller

Stochastic modeling of disease dynamics has had a long tradition. Among the first epidemic models including a spatial structure in the form of local interactions is the contact process. In this article we investigate two extensions of the…

Probability · Mathematics 2007-05-23 L. Belhadji , N. Lanchier

We develop an agent-based model to assess the cumulative number of deaths during hypothetical Covid-19-like epidemics for various non-pharmaceutical intervention strategies. We consider local and non-local modes of disease transmission. The…

Physics and Society · Physics 2020-11-16 Zdzislaw Burda

We explore the emergence of persistent infection in a patch of population, where the disease progression of the individuals is given by the SIRS model and an individual becomes infected on contact with another infected individual. We…

Populations and Evolution · Quantitative Biology 2018-05-08 Vidit Agrawal , Promit Moitra , Sudeshna Sinha

Multiple mechanisms in the HIV lifecycle play a role in its ability to evade therapy and become a chronic, difficult-to-treat infection. Within its major cellular target, the activated T cell, many steps occur between viral entry and viral…

Cell Behavior · Quantitative Biology 2017-12-04 Jayodita C. Sanghvi , Don Mai , Adam P. Arkin , David V. Schaffer

We study a multistage epidemic model which generalizes the SIR model and where infected individuals go through K>0 stages of the epidemic before being removed. An infected individual in stage k=1,...,K may infect a susceptible individual,…

Probability · Mathematics 2014-07-11 Florian Simatos

We propose two SIR models which incorporate sociological behavior of groups of individuals. It is these differences in behaviors which impose different infection rates on the individual susceptible populations, rather than biological…

Dynamical Systems · Mathematics 2022-07-26 Robert F. Allen , Katherine Heller , Matthew A. Pons

During an epidemic outbreak, decision makers crucially need accurate and robust tools to monitor the pathogen propagation. The effective reproduction number, defined as the expected number of secondary infections stemming from one…

Signal Processing · Electrical Eng. & Systems 2026-01-14 Etienne Lasalle , Barbara Pascal

Many important questions in infectious disease epidemiology involve the effects of covariates (e.g., age or vaccination status) on infectiousness and susceptibility, which can be measured in studies of transmission in households or other…

Applications · Statistics 2025-06-27 Yushuf Sharker , Zaynab Diallo , Wasiur R. KhudaBukhsh , Eben Kenah

In this study we analyze the evolution of the effective reproduction number, $R$, through a SIR spreading process in heterogeneous networks; Characterizing its decay process allows to analytically study the effects of countermeasures on the…

Social and Information Networks · Computer Science 2022-07-26 Jhonatan Tavori , Hanoch Levy

Networks of contacts capable of spreading infectious diseases are often observed to be highly heterogeneous, with the majority of individuals having fewer contacts than the mean, and a significant minority having relatively very many…

Physics and Society · Physics 2016-12-21 César Parra-Rojas , Thomas House , Alan J. McKane

We define and study an open stochastic SIR (Susceptible -- Infected -- Removed) model on a graph in order to describe the spread of an epidemic on a cattle trade network with epidemiological and demographic dynamics occurring over the same…

Probability · Mathematics 2019-03-28 Pierre Montagnon

We propose a novel approach to approximate the basic reproduction number $R_0$ as spectral radius of the Next-Generation Operator in time-periodic population models by characterizing the latter via evolution semigroups. Once birth/infection…

Numerical Analysis · Mathematics 2025-09-03 Dimitri Breda , Simone De Reggi , Jordi Ripoll

Time varying susceptibility of host at individual level due to waning and boosting immunity is known to induce rich long-term behavior of disease transmission dynamics. Meanwhile, the impact of the time varying heterogeneity of host…

Populations and Evolution · Quantitative Biology 2018-08-28 Yukihiko Nakata , Ryosuke Omori

Approximating the time to extinction of infection is an important problem in infection modelling. A variety of different approaches have been proposed in the literature. We study the performance of a number of such methods, and characterize…

Probability · Mathematics 2017-07-11 Damian Clancy , Elliott Tjia

In mammals, female germ cells are sheltered within somatic structures called ovarian follicles, which remain in a quiescent state until they get activated, all along reproductive life. We investigate the sequence of somatic cell events…

Cell Behavior · Quantitative Biology 2020-12-10 Frédérique Clément , Frédérique Robin , Romain Yvinec
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