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Now over 20 years old, functional MRI (fMRI) has a large and growing literature that is best synthesised with meta-analytic tools. As most authors do not share image data, only the peak activation coordinates (foci) reported in the paper…

In this work we perform a meta-analysis of neuroimaging data, consisting of locations of peak activations identified in 162 separate studies on emotion. Neuroimaging meta-analyses are typically performed using kernel-based methods. However,…

Applications · Statistics 2012-06-29 Yu Ryan Yue , Martin A. Lindquist , Ji Meng Loh

Motivation: Recent advances in technology for brain imaging and high-throughput genotyping have motivated studies examining the influence of genetic variation on brain structure. Wang et al. (Bioinformatics, 2012) have developed an approach…

Methodology · Statistics 2016-10-18 Keelin Greenlaw , Elena Szefer , Jinko Graham , Mary Lesperance , Farouk S. Nathoo

Inverse problems and, in particular, inferring unknown or latent parameters from data are ubiquitous in engineering simulations. A predominant viewpoint in identifying unknown parameters is Bayesian inference where both prior information…

Computation · Statistics 2022-08-31 Vahid Keshavarzzadeh , Robert M. Kirby , Akil Narayan

Working memory (WM) was one of the first cognitive processes studied with functional magnetic resonance imaging. With now over 20 years of studies on WM, each study with tiny sample sizes, there is a need for meta-analysis to identify the…

Hierarchical data with multiple observations per group is ubiquitous in empirical sciences and is often analyzed using mixed-effects regression. In such models, Bayesian inference gives an estimate of uncertainty but is analytically…

Machine Learning · Computer Science 2026-02-05 Alex Kipnis , Marcel Binz , Eric Schulz

Network meta-analysis (NMA) synthesizes evidence for multiple treatments, but decisions on node formation can have important statistical implications including bias or inflated uncertainty. Existing data-driven methods often lack…

Methodology · Statistics 2025-06-30 Timothy Disher , Chris Cameron , Brian Hutton

Reaching a global view of brain organization requires assembling evidence on widely different mental processes and mechanisms. The variety of human neuroscience concepts and terminology poses a fundamental challenge to relating brain…

Quantitative Methods · Quantitative Biology 2020-02-24 Jérôme Dockès , Russell Poldrack , Romain Primet , Hande Gözükan , Tal Yarkoni , Fabian Suchanek , Bertrand Thirion , Gaël Varoquaux

In regression-based analyses of group-level neuroimage data researchers typically fit a series of marginal general linear models to image outcomes at each spatially-referenced pixel. Spatial regularization of effects of interest is usually…

Methodology · Statistics 2024-09-26 Andrew S. Whiteman , Timothy D. Johnson , Jian Kang

Coordinate-based meta-analysis combines evidence from a collection of Neuroimaging studies to estimate brain activation. In such analyses, a key practical challenge is to find a computationally efficient approach with good statistical…

The willingness to trust predictions formulated by automatic algorithms is key in a vast number of domains. However, a vast number of deep architectures are only able to formulate predictions without an associated uncertainty. In this…

Image and Video Processing · Electrical Eng. & Systems 2022-09-28 Matteo Ferrante , Tommaso Boccato , Nicola Toschi

Determining the best model or models for a particular data set, a process known as Bayesian model comparison, is a critical part of probabilistic inference. Typically, this process assumes a fixed model-space (that is, a fixed set of…

Quantitative Methods · Quantitative Biology 2019-01-08 Thomas HB FitzGerald , Dorothea Hammerer , Thomas D Sambrook , Will D Penny

The accurate assessment of neuroimaging specificity is critical for advancing our understanding of brain disorders. Current methodologies often rely on frequentist approaches and limited cross-pathology comparisons, leading to potential…

Methodology · Statistics 2025-01-07 Tommaso Costa , Franco Cauda

We provide an overview of the state-of-the-art for mathematical methods that are used to reconstruct brain activity from neurophysiological data. After a brief introduction on the mathematics of the forward problem, we discuss standard and…

Quantitative Methods · Quantitative Biology 2017-05-09 Alberto Sorrentino , Michele Piana

A central question in multimodal neuroimaging analysis is to understand the association between two imaging modalities and to identify brain regions where such an association is statistically significant. In this article, we propose a…

Methodology · Statistics 2024-11-28 Moyan Li , Lexin Li , Jian Kang

Bayesian meta-learning enables robust and fast adaptation to new tasks with uncertainty assessment. The key idea behind Bayesian meta-learning is empirical Bayes inference of hierarchical model. In this work, we extend this framework to…

Machine Learning · Computer Science 2020-11-19 Yayi Zou , Xiaoqi Lu

In a meta-analysis, it is important to specify a model that adequately describes the effect-size distribution of the underlying population of studies. The conventional normal fixed-effect and normal random-effects models assume a normal…

Methodology · Statistics 2013-10-21 George Karabatsos , Elizabeth Talbott , Stephen G. Walker

Modelling a complex system is almost invariably a challenging task. The incorporation of experimental observations can be used to improve the quality of a model, and thus to obtain better predictions about the behavior of the corresponding…

Computational Physics · Physics 2015-11-24 Massimiliano Bonomi , Carlo Camilloni , Andrea Cavalli , Michele Vendruscolo

In recent years, neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach toward developing integrated, multivariate brain models that can predict categories of mental events. However, large…

Applications · Statistics 2022-09-19 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Machine learning methods for computational imaging require uncertainty estimation to be reliable in real settings. While Bayesian models offer a computationally tractable way of recovering uncertainty, they need large data volumes to be…

Machine Learning · Computer Science 2020-08-24 Francesco Tonolini , Jack Radford , Alex Turpin , Daniele Faccio , Roderick Murray-Smith
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