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In the context of epidemiology, policies for disease control are often devised through a mixture of intuition and brute-force, whereby the set of logically conceivable policies is narrowed down to a small family described by a few…

Populations and Evolution · Quantitative Biology 2021-10-04 Miguel Navascues , Costantino Budroni , Yelena Guryanova

Sequential Model-based Bayesian Optimization has been successful-ly applied to several application domains, characterized by complex search spaces, such as Automated Machine Learning and Neural Architecture Search. This paper focuses on…

Systems and Control · Electrical Eng. & Systems 2020-03-10 Antonio Candelieri , Bruno Galuzzi , Ilaria Giordani , Francesco Archetti

We propose a general framework for studying optimal impulse control problem in the presence of uncertainty on the parameters. Given a prior on the distribution of the unknown parameters, we explain how it should evolve according to the…

Probability · Mathematics 2017-12-06 N. Baradel , B. Bouchard , Ngoc Minh Dang

In this paper, we address an optimal distributed control problem for a non-local model of phase-field type, describing the evolution of tumour cells in presence of a nutrient. The model couples a non-local and viscous Cahn-Hilliard equation…

Analysis of PDEs · Mathematics 2023-10-25 Matteo Fornoni

Optimal Control (OC) is the process of determining control and state trajectories for a dynamic system, over a period of time, in order to optimize a given performance index. With the increasing of variables and complexity, OC problems can…

Optimization and Control · Mathematics 2014-09-02 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…

Analysis of PDEs · Mathematics 2024-10-21 Xinyue Evelyn Zhao , Yixiang Wu , Rachel Leander , Wandi Ding , Suzanne Lenhart

Controlling large-scale systems sometimes requires decentralized computation. Communication among agents is crucial to achieving consensus and optimal global behavior. These negotiation mechanisms are sensitive to attacks on those…

Systems and Control · Electrical Eng. & Systems 2023-01-02 Rafael Accácio Nogueira , Romain Bourdais , Simon Leglaive , Hervé Guéguen

An optimal control problem for the continuity equation is considered. The aim of a controller is to maximize the total mass within a target set at a given type moment. An iterative numerical algorithm for solving this problem is presented.

Optimization and Control · Mathematics 2017-08-21 Nikolay Pogodaev

This work is concerned with optimal control of partial differential equations where the control enters the state equation as a coefficient and should take on values only from a given discrete set of values corresponding to available…

Optimization and Control · Mathematics 2017-02-27 Christian Clason , Karl Kunisch

Optimizing the impact on the economy of control strategies aiming at containing the spread of COVID-19 is a critical challenge. We use daily new case counts of COVID-19 patients reported by local health administrations from different…

Populations and Evolution · Quantitative Biology 2021-03-12 Afroza Shirin , Yen Ting Lin , Francesco Sorrentino

An optimal control problem for the continuity equation is considered. The aim of a "controller" is to maximize the total mass within a target set at a given time moment. The existence of optimal controls is established. For a particular…

Optimization and Control · Mathematics 2015-07-01 Nikolay Pogodaev

In this paper, a stochastic dynamic control strategy is presented to prevent the spread of an infection over a homogeneous network. The infectious process is persistent, i.e., it continues to contaminate the network once it is established.…

Systems and Control · Electrical Eng. & Systems 2020-12-02 Jalal Arabneydi , Amir G. Aghdam

This paper is about numerical control of HIV propagation. The contribution of the paper is threefold: first, a novel model of HIV propagation is proposed; second, the methods from numerical optimal control are successfully applied to the…

Systems and Control · Computer Science 2023-05-30 Dmitry Gromov , Ingo Bulla , Ethan O. Romero-Severson , Oana Silvia Serea

A mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cancer therapies such as surgery and chemical treatments…

Tissues and Organs · Quantitative Biology 2013-06-21 Sebastien Benzekry , Dominique Barbolosi , Assia Benabdallah , Florence Hubert , Philip Hahnfeldt

We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected…

Optimization and Control · Mathematics 2022-01-26 Karam Allali , Sanaa Harroudi , Delfim F. M. Torres

In this paper we design a novel class of online distributed optimization algorithms leveraging control theoretical techniques. We start by focusing on quadratic costs, and assuming to know an internal model of their variation. In this…

Optimization and Control · Mathematics 2026-01-21 Wouter J. A. van Weerelt , Nicola Bastianello

In this paper, we consider a stochastic recursive optimal control problem under model uncertainty. In this framework, the cost function is described by solutions of a family of backward stochastic differential equations. With the help of…

Probability · Mathematics 2020-04-16 Mingshang Hu , Falei Wang

The aim of this paper is to provide a rigorous mathematical analysis of an optimal control problem with SIR dynamics. The main feature of our study is the presence of state constraints (related to intensive care units ICU capacity) and…

Optimization and Control · Mathematics 2021-08-25 Florin Avram , Lorenzo Freddi , Dan Goreac

Distributionally robust control is a well-studied framework for optimal decision making under uncertainty, with the objective of minimizing an expected cost function over control actions, assuming the most adverse probability distribution…

Systems and Control · Electrical Eng. & Systems 2025-08-12 Alexandros E. Tzikas , Lukas Fiechtner , Arec Jamgochian , Mykel J. Kochenderfer

The realization of efficient micro-machines built from active matter requires precise thermodynamic control far from equilibrium. Despite theoretical progress, the focus on single-parameter driving, coupled with strict theoretical…

Soft Condensed Matter · Physics 2026-03-18 Luke K. Davis
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