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Efforts to automate the reconstruction of neural circuits from 3D electron microscopic (EM) brain images are critical for the field of connectomics. An important computation for reconstruction is the detection of neuronal boundaries. Images…

Computer Vision and Pattern Recognition · Computer Science 2015-08-21 Kisuk Lee , Aleksandar Zlateski , Ashwin Vishwanathan , H. Sebastian Seung

Neuroscientists are actively pursuing high-precision maps, or graphs, consisting of networks of neurons and connecting synapses in mammalian and non-mammalian brains. Such graphs, when coupled with physiological and behavioral data, are…

The study of neurocognitive tasks requiring accurate localisation of activity often rely on functional Magnetic Resonance Imaging, a widely adopted technique that makes use of a pipeline of data processing modules, each involving a variety…

Computer Vision and Pattern Recognition · Computer Science 2016-10-14 Albert Vilamala , Kristoffer Hougaard Madsen , Lars Kai Hansen

Noninvasive medical neuroimaging has yielded many discoveries about the brain connectivity. Several substantial techniques mapping morphological, structural and functional brain connectivities were developed to create a comprehensive road…

Machine Learning · Computer Science 2022-09-30 Alaa Bessadok , Mohamed Ali Mahjoub , Islem Rekik

In this paper, we propose a reservoir computing-based and directed graph analysis pipeline. The goal of this pipeline is to define an efficient brain representation for connectivity in stroke data derived from magnetic resonance imaging.…

Machine Learning · Computer Science 2025-01-28 Wojciech Ciezobka , Joan Falco-Roget , Cemal Koba , Alessandro Crimi

A connectivity graph of neurons at the resolution of single synapses provides scientists with a tool for understanding the nervous system in health and disease. Recent advances in automatic image segmentation and synapse prediction in…

Computer Vision and Pattern Recognition · Computer Science 2021-05-17 Felix Gonda , Xueying Wang , Johanna Beyer , Markus Hadwiger , Jeff W. Lichtman , Hanspeter Pfister

Graphs are a useful abstraction of image content. Not only can graphs represent details about individual objects in a scene but they can capture the interactions between pairs of objects. We present a method for training a convolutional…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Alejandro Newell , Jia Deng

Currently, connectomes (e.g., functional or structural brain graphs) can be estimated in humans at $\approx 1~mm^3$ scale using a combination of diffusion weighted magnetic resonance imaging, functional magnetic resonance imaging and…

The construction of brain graphs from functional Magnetic Resonance Imaging (fMRI) data plays a crucial role in enabling graph machine learning for neuroimaging. However, current practices often rely on rigid pipelines that overlook…

Machine Learning · Computer Science 2025-08-19 Qinwen Ge , Roza G. Bayrak , Anwar Said , Catie Chang , Xenofon Koutsoukos , Tyler Derr

Graph machine learning has been extensively studied in both academic and industry. However, as the literature on graph learning booms with a vast number of emerging methods and techniques, it becomes increasingly difficult to manually…

Machine Learning · Computer Science 2024-05-06 Xin Wang , Ziwei Zhang , Haoyang Li , Wenwu Zhu

The human brain is the most complex object of study we encounter today. Mapping the neuronal-level connections between the more than 80 billion neurons in the brain is a hopeless task for science. By the recent advancement of magnetic…

Neurons and Cognition · Quantitative Biology 2020-09-01 Balint Varga , Vince Grolmusz

Advances in Large Language Models (LLMs) have led to remarkable capabilities, yet their inner mechanisms remain largely unknown. To understand these models, we need to unravel the functions of individual neurons and their contribution to…

Machine Learning · Computer Science 2023-06-01 Alex Foote , Neel Nanda , Esben Kran , Ioannis Konstas , Shay Cohen , Fazl Barez

To build the connectomics map of the brain, we developed a new algorithm that can automatically refine the Membrane Detection Probability Maps (MDPM) generated to perform automatic segmentation of electron microscopy (EM) images. To achieve…

Neural and Evolutionary Computing · Computer Science 2015-06-22 Xundong Wu

Mapping the connectome of the human brain using structural or functional connectivity has become one of the most pervasive paradigms for neuroimaging analysis. Recently, Graph Neural Networks (GNNs) motivated from geometric deep learning…

Neurons and Cognition · Quantitative Biology 2022-11-30 Hejie Cui , Wei Dai , Yanqiao Zhu , Xuan Kan , Antonio Aodong Chen Gu , Joshua Lukemire , Liang Zhan , Lifang He , Ying Guo , Carl Yang

Seeing is believing, however, the underlying mechanism of how human visual perceptions are intertwined with our cognitions is still a mystery. Thanks to the recent advances in both neuroscience and artificial intelligence, we have been able…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Yu-Ting Lan , Kan Ren , Yansen Wang , Wei-Long Zheng , Dongsheng Li , Bao-Liang Lu , Lili Qiu

Reconstructing neuronal circuits at the level of synapses is a central problem in neuroscience and becoming a focus of the emerging field of connectomics. To date, electron microscopy (EM) is the most proven technique for identifying and…

Quantitative Methods · Quantitative Biology 2014-12-05 Stephen M. Plaza , Toufiq Parag , Gary B. Huang , Donald J. Olbris , Mathew A. Saunders , Patricia K. Rivlin

Artificial intelligence in construction increasingly depends on structured representations such as Building Information Models and knowledge graphs, yet early-stage building designs are predominantly created as flexible…

Computation · Statistics 2026-01-26 Jun Xiao , Qiong Wang , Yihui Li , Zhexuan Yu , Hao Zhou , Borong Lin

The inability to acquire clean high-resolution (HR) electron microscopy (EM) images over a large brain tissue volume hampers many neuroscience studies. To address this challenge, we propose a deep-learning-based image super-resolution (SR)…

Computer Vision and Pattern Recognition · Computer Science 2024-01-29 Mohammad Khateri , Morteza Ghahremani , Alejandra Sierra , Jussi Tohka

Blood vessel networks in the brain play a crucial role in stroke research, where understanding their topology is essential for analyzing blood flow dynamics. However, extracting detailed topological vessel network information from…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Joël Mathys , Andreas Plesner , Jorel Elmiger , Roger Wattenhofer

NeuroNet is a deep convolutional neural network mimicking multiple popular and state-of-the-art brain segmentation tools including FSL, SPM, and MALPEM. The network is trained on 5,000 T1-weighted brain MRI scans from the UK Biobank Imaging…

Computer Vision and Pattern Recognition · Computer Science 2018-06-13 Martin Rajchl , Nick Pawlowski , Daniel Rueckert , Paul M. Matthews , Ben Glocker