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The neural plausibility of backpropagation has long been disputed, primarily for its use of non-local weight transport $-$ the biologically dubious requirement that one neuron instantaneously measure the synaptic weights of another. Until…

Neurons and Cognition · Quantitative Biology 2020-06-26 Daniel Kunin , Aran Nayebi , Javier Sagastuy-Brena , Surya Ganguli , Jonathan M. Bloom , Daniel L. K. Yamins

Backpropagation, a foundational algorithm for training artificial neural networks, predominates in contemporary deep learning. Although highly successful, it is widely considered biologically implausible, because it relies on precise…

Machine Learning · Computer Science 2025-10-07 Li Ji-An , Marcus K. Benna

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

Learning depends on changes in synaptic connections deep inside the brain. In multilayer networks, these changes are triggered by error signals fed back from the output, generally through a stepwise inversion of the feedforward processing…

Neurons and Cognition · Quantitative Biology 2021-01-05 William F. Podlaski , Christian K. Machens

Backpropagation is driving today's artificial neural networks (ANNs). However, despite extensive research, it remains unclear if the brain implements this algorithm. Among neuroscientists, reinforcement learning (RL) algorithms are often…

Neurons and Cognition · Quantitative Biology 2020-04-24 Benjamin James Lansdell , Prashanth Ravi Prakash , Konrad Paul Kording

The backpropagation algorithm is an invaluable tool for training artificial neural networks; however, because of a weight sharing requirement, it does not provide a plausible model of brain function. Here, in the context of a two-layer…

Neural and Evolutionary Computing · Computer Science 2020-12-01 Siavash Golkar , David Lipshutz , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

Supervised learning in artificial neural networks typically relies on backpropagation, where the weights are updated based on the error-function gradients and sequentially propagated from the output layer to the input layer. Although this…

Neural and Evolutionary Computing · Computer Science 2023-06-06 Giorgia Dellaferrera , Gabriel Kreiman

The Backpropagation algorithm relies on the abstraction of using a neural model that gets rid of the notion of time, since the input is mapped instantaneously to the output. In this paper, we claim that this abstraction of ignoring time,…

Machine Learning · Computer Science 2020-06-19 Alessandro Betti , Marco Gori

We consider artificial neurons which will update their weight coefficients with an internal rule based on backpropagation, rather than using it as an external training procedure. To achieve this we include the backpropagation error estimate…

Neural and Evolutionary Computing · Computer Science 2018-08-07 M. N. Nazarov

Stochastic gradient descent with backpropagation is the workhorse of artificial neural networks. It has long been recognized that backpropagation fails to be a biologically plausible algorithm. Fundamentally, it is a non-local procedure --…

Machine Learning · Statistics 2021-12-24 Ganlin Song , Ruitu Xu , John Lafferty

Traditional backpropagation of error, though a highly successful algorithm for learning in artificial neural network models, includes features which are biologically implausible for learning in real neural circuits. An alternative called…

Machine Learning · Computer Science 2020-11-06 Nasir Ahmad , Marcel A. J. van Gerven , Luca Ambrogioni

Ongoing studies have identified similarities between neural representations in biological networks and in deep artificial neural networks. This has led to renewed interest in developing analogies between the backpropagation learning…

Neural and Evolutionary Computing · Computer Science 2019-06-11 Theodore H. Moskovitz , Ashok Litwin-Kumar , L. F. Abbott

Back-propagation has been the workhorse of recent successes of deep learning but it relies on infinitesimal effects (partial derivatives) in order to perform credit assignment. This could become a serious issue as one considers deeper and…

Machine Learning · Computer Science 2015-11-26 Dong-Hyun Lee , Saizheng Zhang , Asja Fischer , Yoshua Bengio

We introduce Error Forward-Propagation, a biologically plausible mechanism to propagate error feedback forward through the network. Architectural constraints on connectivity are virtually eliminated for error feedback in the brain;…

Neural and Evolutionary Computing · Computer Science 2018-08-13 Adam A. Kohan , Edward A. Rietman , Hava T. Siegelmann

One major criticism of deep learning centers around the biological implausibility of the credit assignment schema used for learning -- backpropagation of errors. This implausibility translates into practical limitations, spanning scientific…

Neural and Evolutionary Computing · Computer Science 2024-03-29 Alexander Ororbia , Ankur Mali , Adam Kohan , Beren Millidge , Tommaso Salvatori

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar

Gradient based learning using error back-propagation (``backprop'') is a well-known contributor to much of the recent progress in AI. A less obvious, but arguably equally important, ingredient is parameter sharing - most well-known in the…

Machine Learning · Computer Science 2022-11-18 Roland Memisevic

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

The spectacular successes of recurrent neural network models where key parameters are adjusted via backpropagation-based gradient descent have inspired much thought as to how biological neuronal networks might solve the corresponding…

Neurons and Cognition · Quantitative Biology 2023-01-18 Yuhan Helena Liu , Stephen Smith , Stefan Mihalas , Eric Shea-Brown , Uygar Sümbül

Backpropagation has rapidly become the workhorse credit assignment algorithm for modern deep learning methods. Recently, modified forms of predictive coding (PC), an algorithm with origins in computational neuroscience, have been shown to…

Neural and Evolutionary Computing · Computer Science 2023-04-07 Umais Zahid , Qinghai Guo , Zafeirios Fountas
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