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This work presents the second-order forward and adjoint sensitivity analysis procedures (SO-FSAP and SO-ASAP) for computing exactly and efficiently the second-order functional derivatives of physical (engineering, biological, etc.) system…

Mathematical Physics · Physics 2015-05-20 Dan G. Cacuci

This work presents the Second-Order Sensitivity Analysis Methodology (2nd-ASAM) for nonlinear systems. This methodology yields exactly and efficiently the second-order functional derivatives of system responses (associated with physical,…

Optimization and Control · Mathematics 2016-01-26 Dan Gabriel Cacuci

Sensitivity analysis plays an important role in searching for constitutive parameters (e.g. permeability) subsurface flow simulations. The mathematics behind is to solve a dynamic constrained optimization problem. Traditional methods like…

Computational Physics · Physics 2019-06-05 Shu Wang , Satish Karra , Daniel O'Malley

This work presents an illustrative application of the Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM) developed by Cacuci (2015) to a paradigm nonlinear heat conduction benchmark, which models a conceptual experimental test…

Optimization and Control · Mathematics 2016-01-29 Dan Gabriel Cacuci

Uncertainty quantification and sensitivity analyses are a vital component for predictive modeling in the sciences and engineering. The adjoint approach to sensitivity analysis requires solving a primary system of equations and a…

Computational Physics · Physics 2016-12-08 Kelli D. Humbird , Ryan G. McClarren

Efficient execution of parameter sensitivity analysis (SA) is critical to allow for its routinely use. The pathology image processing application investigated in this work processes high-resolution whole-slide cancer tissue images from…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-11-01 Eduardo Scartezini , Willian Barreiros , Tahsin Kurc , Jun Kong , Alba C. M. A. Melo , Joel Saltz , George Teodoro

The power flow equations are fundamental to power system planning, analysis, and control. However, the inherent non-linearity and non-convexity of these equations present formidable obstacles in problem-solving processes. To mitigate these…

Optimization and Control · Mathematics 2024-11-15 Paprapee Buason , Sidhant Misra , Jean-Paul Watson , Daniel K. Molzahn

Adjoint-based sensitivity analysis is routinely used today to assess efficiently the effect of open-loop control on the linear stability properties of unstable flows. Sensitivity maps identify regions where small-amplitude control is the…

Fluid Dynamics · Physics 2021-06-18 Edouard Boujo

We propose a new approach to compute an interval over-approximation of the finite time reachable set for a large class of nonlinear systems. This approach relies on the notions of sensitivity matrices, which are the partial derivatives…

Systems and Control · Electrical Eng. & Systems 2021-04-19 Pierre-Jean Meyer , Murat Arcak

We present two analytical formulae for estimating the sensitivity -- namely, the gradient or Jacobian -- at given realizations of an arbitrary-dimensional random vector with respect to its distributional parameters. The first formula…

Machine Learning · Statistics 2025-08-14 Pi-Yueh Chuang , Ahmed Attia , Emil Constantinescu

Motivated by the pressing challenges in the digital twin development for biomanufacturing systems, we introduce an adjoint sensitivity analysis (SA) approach to expedite the learning of mechanistic model parameters. In this paper, we…

Molecular Networks · Quantitative Biology 2024-07-02 Keilung Choy , Wei Xie

This paper proposes low-complexity algorithms for finding approximate second-order stationary points (SOSPs) of problems with smooth non-convex objective and linear constraints. While finding (approximate) SOSPs is computationally…

Optimization and Control · Mathematics 2019-07-11 Songtao Lu , Meisam Razaviyayn , Bo Yang , Kejun Huang , Mingyi Hong

We investigate the problem of sequential linear data prediction for real life big data applications. The second order algorithms, i.e., Newton-Raphson Methods, asymptotically achieve the performance of the "best" possible linear data…

Data Structures and Algorithms · Computer Science 2017-01-20 Burak C. Civek , Suleyman S. Kozat

This paper deals with the problem of estimating second-order parameter sensitivities for stochastic reaction networks, where the reaction dynamics is modeled as a continuous time Markov chain over a discrete state space. Estimation of such…

Probability · Mathematics 2014-07-29 Ankit Gupta , Mustafa Khammash

Second-order optimization methods offer notable advantages in training deep neural networks by utilizing curvature information to achieve faster convergence. However, traditional second-order techniques are computationally prohibitive,…

Machine Learning · Computer Science 2024-10-04 James Vo

This work focuses on the numerical assessment of the accuracy of an adjoint-based gradient in the perspective of variational data assimilation and parameter identification in glaciology. Using noisy synthetic data, we quantify the ability…

Classical Physics · Physics 2014-03-11 Nathan Martin , Jérôme Monnier

Sensitivity analyses reveal the influence of various modeling choices on the outcomes of statistical analyses. While theoretically appealing, they are overwhelmingly inefficient for complex Bayesian models. In this work, we propose…

The efficient method for computing the sensitivities is the adjoint method. The cost of solving an adjoint equation is comparable to the cost of solving the governing equation. Once the adjoint solution is obtained, the sensitivities to any…

Computational Physics · Physics 2018-05-22 Guojun Hu , Tomasz Kozlowski

In this paper we develop a new method for numerically approximating sensitivities in parameter-dependent ordinary differential equations (ODEs). Our approach, intended for situations where the standard forward and adjoint sensitivity…

Numerical Analysis · Mathematics 2024-07-12 Olivia Eriksson , Andrei Kramer , Federica Milinanni , Pierre Nyquist

Neural Ordinary Differential Equations (NODEs) are a new class of models that transform data continuously through infinite-depth architectures. The continuous nature of NODEs has made them particularly suitable for learning the dynamics of…

Machine Learning · Computer Science 2020-10-22 Alexander Norcliffe , Cristian Bodnar , Ben Day , Nikola Simidjievski , Pietro Liò
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