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Most sensory cells use surface receptors to detect environmental stimuli and initiate downstream signaling. Cooperative interactions among sensory receptors is known to play a crucial role in enhancing the sensitivity of biochemical…

Molecular Networks · Quantitative Biology 2014-01-15 Jianmin Sun , Michael Grabe

Collective cell responses to exogenous cues depend on cell-cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli. However, this has not yet been shown experimentally, and, little is known about…

Cells constantly need to monitor the state of the environment to detect changes and timely respond. The detection of concentration changes of a ligand by a set of receptors can be cast as a problem of hypothesis testing, and the cell viewed…

Quantitative Methods · Quantitative Biology 2015-09-30 Stefano Bo , Antonio Celani

Many eukaryotic and prokaryotic cells can exhibit remarkable sensing ability under small gradient of chemical compound. In this study, we approach this phenomenon by considering the contribution of multiple ligands to the chemical kinetics…

Biological Physics · Physics 2013-05-30 Shu-Hao Liou , Chia-Chu Chen

Eukaryotic cells respond to a chemoattractant gradient by forming intracellular gradients of signaling molecules that reflect the extracellular chemical gradient - an ability called directional sensing. Quantitative experiments have…

Cell Behavior · Quantitative Biology 2017-02-08 Keita Kamino , Yohei Kondo

Cells are constantly exposed to diverse stimuli-chemical, mechanical, or electrical-that guide their movement. In physiological conditions, these signals often overlap, as seen during infections, where neutrophils and dendritic cells…

Biological Physics · Physics 2026-03-25 Emiliano Perez Ipiña , Brian A. Camley

Experimental evidence lends support to the conjecture that the ability of chains of cells to sense the gradient of an external chemical concentration could rely on cell-to-cell communication. This is the basis for the gradient sensing…

Quantitative Methods · Quantitative Biology 2021-02-24 Dallas Foster , Collin Victor , Brian Frost , Juan M. Restrepo

With the continuous increase of the spectrum and antennas, endogenous sensing is now possible in the fifth generation and future wireless communication systems. However, sensing is a highly complex task for a heterogeneous communication…

Information Theory · Computer Science 2021-05-10 Jie Yang , Xi Yang , Chao-Kai Wen , Shi Jin

Cells continuously probe their environment with membrane receptors, achieving subsecond adaptation of their behaviour [1-3]. Recently, several receptors, including cadherins, were found to bind ligands with a lifetime of order of one…

Cell Behavior · Quantitative Biology 2007-09-26 Anne Pierres , Anil Prakasam , Dominique Touchard , Anne-Marie Benoliel , Pierre Bongrand , Deborah Leckband

Many eukaryotic cells are able to sense chemical gradients by directly measuring spatial concentration differences. The precision of such gradient sensing is limited by fluctuations in the binding of diffusing particles to specific…

Cell Behavior · Quantitative Biology 2010-06-04 Bo Hu , Wen Chen , Wouter-Jan Rappel , Herbert Levine

Cooperative interactions among sensory receptors provide a general mechanism to increase the sensitivity of signal transduction. In particular, bacterial chemotaxis receptors interact cooperatively to produce an ultrasensitive response to…

Molecular Networks · Quantitative Biology 2011-10-19 Monica Skoge , Yigal Meir , Ned S. Wingreen

Active sensing is traditionally defined as the expenditure of energy, typically in the form of movement, for obtaining information. Here, we propose that the combination of reliance on adaptive sensors, the linkage between movement and…

Neurons and Cognition · Quantitative Biology 2026-05-25 Andrew Lamperski , Debojyoti Biswas , Eric S. Fortune , John Guckenheimer , Kathleen Hoffman , Noah J. Cowan

Cooperative techniques have been shown to significantly improve the performance of wireless systems. Despite being a mature technology in single communication link scenarios, their implementation in wider, and practical, networks poses…

Networking and Internet Architecture · Computer Science 2012-06-04 Andrea Munari , Marco Levorato , Michele Zorzi

Bacterial chemotaxis is controlled by the signalling of a cluster of receptors. A cooperative model is presented, in which coupling between neighbouring receptor dimers enhances the sensitivity with which stimuli can be detected, without…

Biological Physics · Physics 2009-10-31 Yu Shi , Thomas Duke

Eukaryotic cells generally sense chemical gradients using the binding of chemical ligands to membrane receptors. In order to perform chemotaxis effectively in different environments, cells need to adapt to different concentrations. We…

Cell Behavior · Quantitative Biology 2026-04-20 Vishnu Srinivasan , Wei Wang , Brian A. Camley

Dynamical systems across many disciplines are modeled as interacting particles or agents, with interaction rules that depend on a very small number of variables (e.g. pairwise distances, pairwise differences of phases, etc...), functions of…

Machine Learning · Computer Science 2022-08-05 Jinchao Feng , Mauro Maggioni , Patrick Martin , Ming Zhong

Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional…

Cell Behavior · Quantitative Biology 2009-06-22 Robert G. Endres , Ned S. Wingreen

The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

Various biological sensory systems exhibit a response to a relative change of the stimulus, often referred to as fold-change detection. In the last few years fold-change detecting mechanisms, based on transcriptional networks, have been…

Biological Physics · Physics 2014-02-21 Wouter Buijsman , Michael Sheinman

From an enactive approach, some previous studies have demonstrated that social interaction plays a fundamental role in the dynamics of neural and behavioral complexity of embodied agents. In particular, it has been shown that agents with a…

Multiagent Systems · Computer Science 2020-11-04 Georgina Montserrat Reséndiz-Benhumea , Ekaterina Sangati , Tom Froese
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