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This paper addresses the problem of recovering tracer kinetic parameters from multi-region measurement data in quantitative PET imaging using the reversible two tissue compartment model. Its main result is an extension of our previous work…

Optimization and Control · Mathematics 2025-04-15 Martin Holler , Erion Morina , Georg Schramm

The inverse conductivity problem aims at determining the unknown conductivity inside a bounded domain from boundary measurements. In practical applications, algorithms based on minimizing a regularized residual functional subject to PDE…

Numerical Analysis · Mathematics 2025-10-02 Lefu Cai , Zhixin Liu , Minghui Song , Xianchao Wang

The aim of this paper is to establish a nonlinear variational approach to the reconstruction of moving density images from indirect dynamic measurements. Our approach is to model the dynamics as a hyperelastic deformation of an initial…

Numerical Analysis · Mathematics 2015-12-01 Martin Burger , Jan Modersitzki , Sebastian Suhr

In this paper, we propose and study several inverse problems of determining unknown parameters in nonlocal nonlinear coupled PDE systems, including the potentials, nonlinear interaction functions and time-fractional orders. In these coupled…

Analysis of PDEs · Mathematics 2024-07-23 Ming-Hui Ding , Hongyu Liu , Catharine W. K. Lo

This work is concerned with the identifiability of metabolic parameters from multi-region measurement data in quantitative PET imaging. It shows that, for the frequently used two-tissue compartment model and under reasonable assumptions, it…

Optimization and Control · Mathematics 2023-05-29 Martin Holler , Erion Morina , Georg Schramm

Inferring control parameters in non-linear dynamical systems is an important task in analysing general dynamical behaviours, particularly in the presence of inherently deterministic chaos. Traditional approaches often rely on…

Chaotic Dynamics · Physics 2025-06-19 L. Lober , M. S. Palmero , F. A. Rodrigues

In this work we are concerned with the inverse problem of the estimation of modeling parameters for a reactive bimolecular transport based on experimental data that is non-uniformly distributed along the interval where the process takes…

Fluid Dynamics · Physics 2015-09-24 Daniel A. Cuch , Diana Rubio , Claudio D. El Hasi

Dynamic positron emission tomography (PET) images can reveal the distribution of tracers in the organism and the dynamic processes involved in biochemical reactions, and it is widely used in clinical practice. Despite the high effectiveness…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Jie Sun , Junyan Zhang , Qian Xia , Chuanfu Sun , Yumei Chen , Yunjie Yang , Huafeng Liu , Wentao Zhu , Qiegen Liu

This text describes a method to simultaneously reconstruct flow states and determine particle properties from Lagrangian particle tracking (LPT) data. LPT is a popular measurement strategy for fluids in which particles in a flow are…

Fluid Dynamics · Physics 2023-11-16 Ke Zhou , Samuel J. Grauer

The estimation of distributed parameters in partial differential equations (PDE) from measures of the solution of the PDE may lead to under-determination problems. The choice of a parameterization is a usual way of adding a-priori…

Numerical Analysis · Mathematics 2008-01-16 Hend Ben Ameur , François Clément , Pierre Weis , Guy Chavent

We consider the identification of a scalar coefficient in a PDE-based parameter estimation problem with contact constraints. The considered problem can be used as an idealized model of a membrane under forces, constrained by a barrier or…

Numerical Analysis · Mathematics 2026-05-12 Simon Hubmer , Stefan Kindermann , Ekaterina Sherina

We propose a novel dynamic image reconstruction method from PET listmode data that could be particularly suited to tracking single or small numbers of cells. In contrast to conventional PET reconstruction our method combines the information…

Computer Vision and Pattern Recognition · Computer Science 2019-11-25 Bernhard Schmitzer , Klaus P. Schäfers , Benedikt Wirth

Computational inverse problems for biomedical simulators suffer from limited data and relatively high parameter dimensionality. This often requires sensitivity analysis, where parameters of the model are ranked based on their influence on…

Tissues and Organs · Quantitative Biology 2025-06-06 Mitchel J. Colebank

This paper presents a novel data-driven approach to identify partial differential equation (PDE) parameters of a dynamical system. Specifically, we adopt a mathematical "transport" model for the solution of the dynamical system at specific…

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

In this paper we consider the solution of monotone inverse problems using the particular example of a parameter identification problem for a semilinear parabolic PDE. For the regularized solution of this problem, we introduce a total…

Numerical Analysis · Mathematics 2025-02-26 Pankaj Gautam , Markus Grasmair

This paper explores the reconstruction of a space-dependent parameter in inverse diffusion problems, proposing a shape-optimization-based approach. We consider a Robin boundary condition, physically motivated in diffuse optical tomography…

Numerical Analysis · Mathematics 2026-01-27 Manabu Machida , Hirofumi Notsu , Julius Fergy Tiongson Rabago

When considering fractional diffusion equation as model equation in analyzing anomalous diffusion processes, some important parameters in the model related to orders of the fractional derivatives, are often unknown and difficult to be…

Analysis of PDEs · Mathematics 2019-04-15 Zhiyuan Li , Yikan Liu , Masahiro Yamamoto

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…

Medical Physics · Physics 2025-08-28 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Partial differential equation (PDE) models are widely used in engineering and natural sciences to describe spatio-temporal processes. The parameters of the considered processes are often unknown and have to be estimated from experimental…

Numerical Analysis · Mathematics 2016-12-21 Romana Boiger , Jan Hasenauer , Sabrina Hross , Barbara Kaltenbacher
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