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The observation by Ke et al. [Science 338, 1177 (2012)] that large numbers of short, pre-designed DNA strands can assemble into three-dimensional target structures came as a great surprise, as no colloidal self-assembling system has ever…

Soft Condensed Matter · Physics 2014-06-12 Aleks Reinhardt , Daan Frenkel

We use computer simulations to investigate self-assembly in a system of model chaperonin proteins, and in an Ising lattice gas. We discuss the mechanisms responsible for rapid and efficient assembly in these systems, and we use measurements…

Soft Condensed Matter · Physics 2011-12-09 James Grant , Robert L. Jack , Stephen Whitelam

I consider a generic coarse-grained model suitable for the study of bulk self-assembly of liquid crystal (LC) macromolecules. The cases include LC dendrimers, gold nanoparticles modified by polymer chains with terminating LC groups and…

Soft Condensed Matter · Physics 2013-12-17 J. M. Ilnytskyi

We investigate the self-assembly (crystallisation) of particles with hard cores and isotropic, square-well interactions, using a Monte Carlo scheme to simulate overdamped Langevin dynamics. We measure correlation and response functions…

Soft Condensed Matter · Physics 2015-03-19 Daphne Klotsa , Robert L. Jack

The simplest prescription for building a patterned structure from its constituents is to add particles, one at a time, to an appropriate template. However, self-organizing molecular and colloidal systems in nature can evolve in much more…

Statistical Mechanics · Physics 2009-04-07 Stephen Whitelam , Edward H. Feng , Michael F. Hagan , Phillip L. Geissler

Systematic efforts to synthesise fullerene containing LCs have produced a variety of successful model compounds. We present a simple molecular theory relating the self-organisation observed in these systems to their molecular structure. The…

Soft Condensed Matter · Physics 2009-11-11 S. D. Peroukidis , A. G. Vanakaras , D. J. Photinos

The molecular self-assembly of various structures such as micelles and vesicles has been the subject of comprehensive studies. Recently, a new approach to design these structures, the frame-guided assembly, has been developed to progress…

Chemical Physics · Physics 2022-05-11 Simon Raschke , Andreas Heuer

We study the assembling of P3HT chains in vacuo by means of a combination of first principles density functional theory and model potential molecular dynamics. We find that, in the absence of any external constraints, the pi-pi interchain…

Soft Condensed Matter · Physics 2010-06-30 Claudio Melis , Alessandro Mattoni , Luciano Colombo

A systematic investigation of the phase separation dynamics in self-assembled multi-component bilayer fluid vesicles and open membranes is presented. We use large-scale dissipative particle dynamics to explicitly account for solvent,…

Soft Condensed Matter · Physics 2015-06-25 Mohamed Laradji , P. B. Sunil Kumar

Bacterial microcompartments are large, roughly icosahedral shells that assemble around enzymes and reactants involved in certain metabolic pathways in bacteria. Motivated by microcompartment assembly, we use coarse-grained computational and…

Biological Physics · Physics 2019-05-07 Farzaneh Mohajerani , Michael F. Hagan

We elucidate the molecular forces leading to assembly of two dimensional membrane-like structures composed of a one rod-length thick monolayer of aligned rods from an immiscible suspension of hard rods and depleting polymers. We perform…

Soft Condensed Matter · Physics 2011-03-15 Yasheng Yang , Edward Barry , Zvonimir Dogic , Michael F. Hagan

Structure formation and constant reorganization of the actin cytoskeleton are key requirements for the function of living cells. Here we show that a minimal reconstituted system consisting of actin filaments, crosslinking molecules and…

Biological Physics · Physics 2015-05-27 Simone Köhler , Volker Schaller , Andreas R. Bausch

The actin cytoskeleton is a key component in the machinery of eukaryotic cells, and it selfassembles out of equilibrium into a wide variety of biologically crucial structures. While the molecular mechanisms involved are well characterized,…

Soft Condensed Matter · Physics 2017-01-04 Giulia Foffano , Nicolas Levernier , Martin Lenz

We examine the budding of a nanoscale particle through a lipid bilayer using molecular dynamics simulations, free energy calculations, and an elastic theory, with the aim of determining the extent to which equilibrium elasticity theory can…

Subcellular Processes · Quantitative Biology 2012-02-22 Teresa Ruiz-Herrero , Enrique Velasco , Michael F. Hagan

Multilevel self-assembly involving small structured groups of nano-particles provides new routes to development of functional materials with a sophisticated architecture. Apart from the inter-particle forces, the geometrical shapes and…

Physics and Society · Physics 2017-11-15 Milovan Suvakov , Miroslav Andjelkovic , Bosiljka Tadic

Molecular dynamics simulation is used to model the self-assembly of polyhedral shells containing 180 trapezoidal particles that correspond to the T=3 virus capsid. Three kinds of particle, differing only slightly in shape, are used to…

Biomolecules · Quantitative Biology 2020-04-01 D. C. Rapaport

I present a review of the theoretical and computational methodologies that have been used to model the assembly of viral capsids. I discuss the capabilities and limitations of approaches ranging from equilibrium continuum theories to…

Biomolecules · Quantitative Biology 2013-01-09 Michael F. Hagan

The elastic property of membranes self-assembled from AB diblock and ABA triblock copolymers, as coarse-grained model of lipids and the bolalipids, are studied using the self-consistent field theory (SCFT). Specifically, solutions of the…

Soft Condensed Matter · Physics 2019-05-17 Rui Xu , Ashkan Dehghan , An-Chang Shi , Jiajia Zhou

In contrast to most self-assembling synthetic materials, which undergo unbounded growth, many biological self-assembly processes are self-limited. That is, the assembled structures have one or more finite dimensions that are much larger…

Soft Condensed Matter · Physics 2022-05-25 Huang Fang , Botond Tyukodi , W. Benjamin Rogers , Michael F. Hagan

The singularity structure and the corresponding asymptotic behavior of a 3-brane coupled to a scalar field in a five dimensional bulk is analyzed in full generality, using the method of asymptotic splittings. It is shown that the collapse…

General Relativity and Quantum Cosmology · Physics 2010-04-21 Ignatios Antoniadis , Spiros Cotsakis , Ifigeneia Klaoudatou