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Nested canalization (NC) is a property of Boolean functions which has been recently extended to multivalued functions. We study the effect of the Van Ham mapping (from multivalued to Boolean functions) on this property. We introduce the…

Combinatorics · Mathematics 2023-10-31 Élisabeth Remy , Paul Ruet

Canalizing functions have important applications in physics and biology. For example, they represent a mechanism capable of stabilizing chaotic behavior in Boolean network models of discrete dynamical systems. When comparing the class of…

Mathematical Physics · Physics 2009-11-10 Winfried Just , Ilya Shmulevich , John Konvalina

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

Molecular Networks · Quantitative Biology 2022-12-29 Niklas Bonacker , Johannes Berg

The functions of many networked systems in physics, biology or engineering rely on a coordinated or synchronized dynamics of its constituents. In power grids for example, all generators must synchronize and run at the same frequency and…

Adaptation and Self-Organizing Systems · Physics 2017-09-13 Debsankha Manik , Marc Timme , Dirk Witthaut

We determine stability and attractor properties of random Boolean genetic network models with canalyzing rules for a variety of architectures. For all power law, exponential, and flat in-degree distributions, we find that the networks are…

Molecular Networks · Quantitative Biology 2007-05-23 Stuart Kauffman , Carsten Peterson , Björn Samuelsson , Carl Troein

This work presents a novel methodology for analysis and control of nonlinear fluid systems using neural networks. The approach is demonstrated on four different study cases being the Lorenz system, a modified version of the…

Fluid Dynamics · Physics 2023-08-28 Tarcísio Déda , William Wolf , Scott Dawson

We introduce a new sequential methodology to calibrate the fixed parameters and track the stochastic dynamical variables of a state-space system. The proposed method is based on the nested hybrid filtering (NHF) framework of [1], that…

Computation · Statistics 2021-03-24 Sara Pérez-Vieites , Joaquín Míguez

Boolean nested canalizing functions (NCFs) have important applications in molecular regulatory networks, engineering and computer science. In this paper, we study their certificate complexity. For both Boolean values $b\in\{0,1\}$, we…

Combinatorics · Mathematics 2021-02-15 Yuan Li , Frank Ingram , Huaming Zhang

Boolean nested canalizing functions (NCFs) have important applications in molecular regulatory networks, engineering and computer science. In this paper, we study their certificate complexity. For both Boolean values $b\in\{0,1\}$, we…

Discrete Mathematics · Computer Science 2023-06-22 Yuan Li , Frank Ingram , Huaming Zhang

Boolean Networks have been used to study numerous phenomena, including gene regulation, neural networks, social interactions, and biological evolution. Here, we propose a general method for determining the critical behavior of Boolean…

Disordered Systems and Neural Networks · Physics 2009-11-11 Andre A. Moreira , Luis A. N. Amaral

Based on a recent characterization of nested canalyzing function (NCF), we obtain the formula of the sensitivity of any NCF. Hence we find that any sensitivity of NCF is between $\frac{n+1}{2}$ and $n$. Both lower and upper bounds are…

Discrete Mathematics · Computer Science 2012-09-10 Yuan Li , John O. Adeyeye

Boolean variables are such that they take only values on $ \mathbb{Z}_2 \cong \left\{0, 1 \right\} $. \textit{NK}-Kauffman networks are dynamical deterministic systems of $ N $ Boolean functions that depend only on $ K \leq N $ Boolean…

Adaptation and Self-Organizing Systems · Physics 2014-04-14 Federico Zertuche

We study distributed control of networked systems through reinforcement learning, where neural policies must be simultaneously scalable, expressive and stabilizing. We introduce a policy parameterization that embeds Graph Neural Networks…

Systems and Control · Electrical Eng. & Systems 2026-05-27 John Cao , Luca Furieri

Boolean network models have gained popularity in computational systems biology over the last dozen years. Many of these networks use canalizing Boolean functions, which has led to increased interest in the study of these functions. The…

Discrete Mathematics · Computer Science 2015-04-29 Qijun He , Matthew Macauley

Normalizing Flows (NFs) are able to model complicated distributions p(y) with strong inter-dimensional correlations and high multimodality by transforming a simple base density p(z) through an invertible neural network under the change of…

Machine Learning · Computer Science 2023-11-14 Christina Winkler , Daniel Worrall , Emiel Hoogeboom , Max Welling

We prove that nested canalizing functions are the minimum-sensitivity Boolean functions for any given activity ratio and we characterize the sensitivity boundary which has a nontrivial fractal structure. We further observe, on an extensive…

Molecular Networks · Quantitative Biology 2022-03-23 H. Coban , A. Kabakcioglu

Neuronal activity is found to lie on low-dimensional manifolds embedded within the high-dimensional neuron space. Variants of principal component analysis are frequently employed to assess these manifolds. These methods are, however,…

Neurons and Cognition · Quantitative Biology 2025-06-19 Peter Bouss , Sandra Nestler , Kirsten Fischer , Claudia Merger , Alexandre René , Moritz Helias

Developing efficient computational methods to assess the impact of external interventions on the dynamics of a network model is an important problem in systems biology. This paper focuses on quantifying the global changes that result from…

Molecular Networks · Quantitative Biology 2024-07-09 David Murrugarra , Elena Dimitrova

Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical rules. They were introduced as dynamic models into biology, in particular as logical models of intracellular regulatory…

Dynamical Systems · Mathematics 2025-04-16 J. García Galofre , M. Pérez Millán , A. Galarza Rial , R. Laubenbacher , A. Dickenstein

We propose a Neural-Enhanced Distributed Kalman Filter (NDKF) for multi-sensor state estimation in nonlinear systems. Unlike traditional Kalman filters that rely on explicit analytical models and assume centralized fusion, NDKF leverages…

Systems and Control · Electrical Eng. & Systems 2026-03-17 Siavash Farzan , Bennett Parisi