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This paper provides a dynamical frame to study non-autonomous parabolic partial differential equations with finite delay. Assuming monotonicity of the linearized semiflow, conditions for the existence of a continuous separation of type II…

Dynamical Systems · Mathematics 2018-08-14 Rafael Obaya , Ana M. Sanz

We introduce and analyze several aspects of a new model for cell differentiation. It assumes that differentiation of progenitor cells is a continuous process. From the mathematical point of view, it is based on partial differential…

Analysis of PDEs · Mathematics 2013-01-21 Marie Doumic , Anna Marciniak-Czochra , Benoit Perthame , Jorge P. Zubelli

In this paper, we establish the existence of a positive, bounded solution for a class of parabolic partial differential equations with nonlinear boundary conditions, where the boundary conditions depend on the solution on the boundary at a…

Dynamical Systems · Mathematics 2025-07-15 Gangadhara Boregowda , Michael R. Lindstrom

In the present article, we discuss some aspects of the local stability analysis for a class of abstract functional differential equations. This is done under smoothness assumptions which are often satisfied in the presence of a…

Dynamical Systems · Mathematics 2015-02-12 Eugen Stumpf

We present a novel mathematical model of heterogeneous cell proliferation where the total population consists of a subpopulation of slow-proliferating cells and a subpopulation of fast-proliferating cells. The model incorporates two…

Cell Behavior · Quantitative Biology 2021-11-04 Sean T. Vittadello , Scott W. McCue , Gency Gunasingh , Nikolas K. Haass , Matthew J. Simpson

In this paper we consider a class of differential equations with state-dependent delays. We show first and second-order differentiability of the solution with respect to parameters in a pointwise sense and also using the C-norm on the…

Dynamical Systems · Mathematics 2012-01-04 Ferenc Hartung

In the standard theory of delay equations, the fundamental solution does not 'live' in the state space. To eliminate this age-old anomaly, we enlarge the state space. As a consequence, we lose the strong continuity of the solution operators…

Dynamical Systems · Mathematics 2021-03-22 Odo Diekmann , Sjoerd Verduyn Lunel

The paper concerns a class of $n$-dimensional non-autonomous delay differential equations obtained by adding a non-monotone delayed perturbation to a linear homogeneous cooperative system of ordinary differential equations. This family…

Classical Analysis and ODEs · Mathematics 2018-07-10 Teresa Faria , Rafael Obaya , Ana M. Sanz

To describe the dynamics of a size-structured population and its unstructured resource, we formulate bookkeeping equations in two different ways. The first, called the PDE formulation, is rather standard. It employs a first order partial…

Analysis of PDEs · Mathematics 2022-02-07 Carles Barril , Àngel Calsina , Odo Diekmann , Jozsef Z. Farkas

This paper investigates the stability properties of a nonlinear fractional differential equation with two discrete delays and a delay-dependent coefficient. Such equations arise in various biological and control systems where temporal…

Dynamical Systems · Mathematics 2026-03-12 Pragati Dutta , Sachin Bhalekar

We discuss the non-uniqueness of continuous solutions to differential equations with a {\it discrete } state-dependent delay and continuous initial functions. We are interested not only in the fact (conditions) of non-uniqueness, but in…

Classical Analysis and ODEs · Mathematics 2026-04-14 Alexander Rezounenko

Long-term memory is a feature observed in systems ranging from neural networks to epidemiological models. The memory in such systems is usually modeled by the time delay. Furthermore, the nonlocal operators, such as the "fractional order…

Dynamical Systems · Mathematics 2023-05-12 Divya D. Joshi , Sachin Bhalekar , Prashant M. Gade

We consider a population organised hierarchically with respect to size in such a way that the growth rate of each individual depends only on the presence of larger individuals. As a concrete example one might think of a forest, in which the…

Populations and Evolution · Quantitative Biology 2024-04-23 Carles Barril , Àngel Calsina , Odo Diekmann , József Z. Farkas

We present a detailed study of a scalar differential equation with threshold state-dependent delayed feedback. This equation arises as a simplification of a gene regulatory model. There are two monotone nonlinearities in the model: one…

Dynamical Systems · Mathematics 2025-04-29 Tomas Gedeon , Antony R. Humphries , Michael C. Mackey , Hans-Otto Walther , Zhao Wang

We derive an alternative expression for a delayed logistic equation in which the rate of change in the population involves a growth rate that depends on the population density during an earlier time period. In our formulation, the delay in…

Dynamical Systems · Mathematics 2022-06-07 Chiu-Ju Lin , Ting-Hao Hsu , Gail S. K. Wolkowicz

Recent biological evidence suggests the presence of a two-phase ageing process in several species. We introduce a system of two age-structured partial differential equations (PDE) representing two phases of ageing of a wild population. The…

Analysis of PDEs · Mathematics 2026-03-24 Luce Breuil

We prove the equivalence of the well-posedness of a partial differential equation with delay and an associated abstract Cauchy problem. This is used to derive sufficient conditions for well-posedness, exponential stability and norm…

Functional Analysis · Mathematics 2012-12-03 András Bátkai , Susanna Piazzera

We give answer to an open question by proving a sufficient optimality condition for state-linear optimal control problems with time delays in state and control variables. In the proof of our main result, we transform a delayed state-linear…

Optimization and Control · Mathematics 2019-04-03 Ana P. Lemos-Paiao , Cristiana J. Silva , Delfim F. M. Torres

The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and…

Cell Behavior · Quantitative Biology 2013-06-12 Mithun K. Mitra , Paul R. Taylor , Chris J. Hutchison , T. C. B. McLeish , Buddhapriya Chakrabarti

The present paper deals with autonomous integral equations with infinite delay via dynamical system approach. Existence, local exponential attractivity, and other properties of center manifold are established by means of the…

Dynamical Systems · Mathematics 2012-12-05 Hideaki Matsunaga , Satoru Murakami , Yutaka Nagabuchi , Nguyen Van Minh