Related papers: Variable-Order de Bruijn Graphs

A de Bruijn sequence of order $k$ over a finite alphabet is a cyclic sequence with the property that it contains every possible $k$-sequence as a substring exactly once. Orthogonal de Bruijn sequences are collections of de Bruijn sequences…

Pangenomes serve as a framework for joint analysis of genomes of related organisms. Several pangenome models were proposed, offering different functionalities, applications provided by available tools, their efficiency etc. Among them, two…

Motivation: Intimately tied to assembly quality is the complexity of the de Bruijn graph built by the assembler. Thus, there have been many paradigms developed to decrease the complexity of the de Bruijn graph. One obvious combinatorial…

The de Bruijn graph, its sequences, and their various generalizations, have found many applications in information theory, including many new ones in the last decade. In this paper, motivated by a coding problem for emerging memory…

Background Next Generation Sequencing (NGS) has dramatically enhanced our ability to sequence genomes, but not to assemble them. In practice, many published genome sequences remain in the state of a large set of contigs. Each contig…

The greedy Prefer-same de Bruijn sequence construction was first presented by Eldert et al.[AIEE Transactions 77 (1958)]. As a greedy algorithm, it has one major downside: it requires an exponential amount of space to store the length $2^n$…

Genome assembly is a fundamental problem in Bioinformatics, where for a given set of overlapping substrings of a genome, the aim is to reconstruct the source genome. The classical approaches to solving this problem use assembly graphs, such…

The problem of assembling DNA fragments starting from imperfect strings given by a sequencer, classified as NP hard when trying to get perfect answers, has a huge importance in several fields, because of its relation with the possibility of…

A graph $G=(V,E)$ is word-representable if there exists a word $w$ over the alphabet $V$ such that letters $x$ and $y$ alternate in $w$ if and only if $xy\in E$. For integers $n>k>0 $, the shift graph $G(n,k)$ is the graph whose vertex set…

We initiate the study of computational problems on $k$-mers (strings of length $k$) in labeled graphs. As a starting point, we consider the problem of counting the number of distinct $k$-mers found on the walks of a graph. We establish that…

DNA technologies have evolved significantly in the past years enabling the sequencing of a large number of genomes in a short time. Nevertheless, the underlying computational problem is hard, and many technical factors and limitations…

A de Bruijn cycle is a cyclic listing of length A, of a collection of A combinatorial objects, so that each object appears exactly once as a set of consecutive elements in the cycle. In this paper, we show the power of de Bruijn's original…

This paper presents a method to find new De Bruijn cycles based on ones of lesser order. This is done by mapping a De Bruijn cycle to several vertex disjoint cycles in a De Bruijn digraph of higher order and connecting these cycles into one…

Binary time series data are very common in many applications, and are typically modelled independently via a Bernoulli process with a single probability of success. However, the probability of a success can be dependent on the outcome…

Glycans are the most complex biological sequence, with monosaccharides forming extended, non-linear sequences. As post-translational modifications, they modulate protein structure, function, and interactions. Due to their diversity and…

In this thesis, we address the problem of identifying and quantifying variants (alternative splicing and genomic polymorphism) in RNA-seq data when no reference genome is available, without assembling the full transcripts. Based on the…

A cut-down de Bruijn sequence is a cyclic string of length $L$, where $1 \leq L \leq k^n$, such that every substring of length $n$ appears at most once. Etzion [Theor. Comp. Sci 44 (1986)] gives an algorithm to construct binary cut-down de…

One of the most computationally intensive tasks in computational biology is de novo genome assembly, the decoding of the sequence of an unknown genome from redundant and erroneous short sequences. A common assembly paradigm identifies…

A de Bruijn array code is a set of $r \times s$ binary doubly-periodic arrays such that each binary $n \times m$ matrix is contained exactly once as a window in one of the arrays. Such a set of arrays can be viewed as a two-dimensional…

For positive integers $k,n$, a de Bruijn sequence $B(k,n)$ is a finite sequence of elements drawn from $k$ characters whose subwords of length $n$ are exactly the $k^n$ words of length $n$ on $k$ characters. This paper introduces the…