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The multiple-biomarker classifier problem and its assessment are reviewed against the background of some fundamental principles from the field of statistical pattern recognition, machine learning, or the recently so-called "data science". A…

Genomics · Quantitative Biology 2019-11-01 Waleed A. Yousef

Ideally, a meta-analysis will summarize data from several unbiased studies. Here we consider the less than ideal situation in which contributing studies may be compromised by measurement error. Measurement error affects every study design,…

Quantum computing offers new opportunities for addressing complex classification tasks in biomedical applications. This study investigates two quantum machine learning models-the Quantum Support Vector Machine (QSVM) and the Variational…

Quantum Physics · Physics 2025-04-16 Chi-Chuan Hwang , Cheng-Fang Su , Yi-Ang Hong

Multi-gene panel testing allows efficient detection of pathogenic variants in cancer susceptibility genes including moderate-risk genes such as ATM and PALB2. A growing number of studies examine the risk of breast cancer (BC) conferred by…

When testing for superiority in a parallel-group setting with a continuous outcome, adjusting for covariates (e.g., baseline measurements) is usually recommended, in order to reduce bias and increase power. For this purpose, the analysis of…

Methodology · Statistics 2020-04-28 Georg Zimmermann , Meinhard Kieser , Arne Bathke

Regulation, legal liabilities, and societal concerns challenge the adoption of AI in safety and security-critical applications. One of the key concerns is that adversaries can cause harm by manipulating model predictions without being…

Machine Learning · Computer Science 2023-01-31 Jona Klemenc , Holger Trittenbach

The paper investigates the techniques of quantum computation in metrological predictions, with a particular emphasis on enhancing prediction potential through variational parameter estimation. The applicability of quantum simulations and…

Quantum Physics · Physics 2025-01-31 Vaidik A Sharma , N. Madurai Meenachi , B. Venkatraman

We introduce a simple but effective method for managing risk in model-based reinforcement learning with trajectory sampling that involves probabilistic safety constraints and balancing of optimism in the face of epistemic uncertainty and…

Machine Learning · Computer Science 2023-09-12 Marin Vlastelica , Sebastian Blaes , Cristina Pineri , Georg Martius

A dynamic treatment regime is a sequence of decision rules in which each decision rule recommends treatment based on features of patient medical history such as past treatments and outcomes. Existing methods for estimating optimal dynamic…

Methodology · Statistics 2015-05-22 Kristin A. Linn , Eric B. Laber , Leonard A. Stefanski

We suggest double/debiased machine learning estimators of direct and indirect quantile treatment effects under a selection-on-observables assumption. This permits disentangling the causal effect of a binary treatment at a specific outcome…

Econometrics · Economics 2023-07-04 Yu-Chin Hsu , Martin Huber , Yu-Min Yen

The Linear Ballistic Accumulator (Brown & Heathcote, 2008) model is used as a measurement tool to answer questions about applied psychology. The analyses based on this model depend upon the model selected and its estimated parameters.…

Methodology · Statistics 2020-03-03 David Gunawan , Guy E. Hawkins , Minh-Ngoc Tran , Robert Kohn , Scott Brown

Quantum Molecular Dynamics models (QMD) are Monte Carlo approaches targeted at the description of nucleon-ion and ion-ion collisions. We have developed a QMD code, which has been used for the simulation of the fast stage of ion-ion…

The Binary Emax model is widely employed in dose-response analysis during Phase II clinical studies to identify the optimal dose for subsequence confirmatory trials. The parameter estimation and inference heavily rely on the asymptotic…

Applications · Statistics 2026-02-04 Jiangshan Zhang , Vivek Pradhan , Yuxi Zhao

Evidence accumulation models (EAMs) are an important class of cognitive models used to analyze both response time and response choice data recorded from decision-making tasks. Developments in estimation procedures have helped EAMs become…

Methodology · Statistics 2023-06-01 Viet Hung Dao , David Gunawan , Robert Kohn , Minh-Ngoc Tran , Guy E. Hawkins , Scott D. Brown

We propose a novel approach to model selection for simulator-based statistical models. The proposed approach defines a mixture of candidate models, and then iteratively updates the weight coefficients for those models as well as the…

Machine Learning · Statistics 2019-02-08 Takafumi Kajihara , Motonobu Kanagawa , Yuuki Nakaguchi , Kanishka Khandelwal , Kenji Fukumiziu

Quantum scattering calculations for all but low-dimensional systems at low energies must rely on approximations. All approximations introduce errors. The impact of these errors is often difficult to assess because they depend on the…

Accurate and rapid structural damage assessment (SDA) is crucial for post-disaster management, helping responders prioritise resources, plan rescues, and support recovery. Traditional field inspections, though precise, are limited by…

Artificial Intelligence · Computer Science 2026-04-14 Wanli Ma , Sivasakthy Selvakumaran , Dain G. Farrimond , Adam A. Dennis , Samuel E. Rigby

Active learning can improve the efficiency of training prediction models by identifying the most informative new labels to acquire. However, non-response to label requests can impact active learning's effectiveness in real-world contexts.…

Machine Learning · Computer Science 2024-03-12 Thomas Robinson , Niek Tax , Richard Mudd , Ido Guy

Despite the remarkable proficiency of \textit{Large Reasoning Models} (LRMs) in handling complex reasoning tasks, their reliability in safety-critical scenarios remains uncertain. Existing evaluations primarily assess response-level safety,…

Artificial Intelligence · Computer Science 2025-05-27 Baihui Zheng , Boren Zheng , Kerui Cao , Yingshui Tan , Zhendong Liu , Weixun Wang , Jiaheng Liu , Jian Yang , Wenbo Su , Xiaoyong Zhu , Bo Zheng , Kaifu Zhang

Real-world problems such as landmine detection require multiple sources of information to reduce the uncertainty of decision-making. A novel approach to solve these problems includes distributed systems, as presented in this work based on…

Machine Learning · Computer Science 2020-04-14 Johana Florez-Lozano , Fabio Caraffini , Carlos Parra , Mario Gongora
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