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Structured prediction tasks in machine learning involve the simultaneous prediction of multiple labels. This is typically done by maximizing a score function on the space of labels, which decomposes as a sum of pairwise elements, each…

Machine Learning · Computer Science 2014-09-23 Amir Globerson , Tim Roughgarden , David Sontag , Cafer Yildirim

Independent of the technology, it is generally expected that future nanoscale devices will be built from vast numbers of densely arranged devices that exhibit high failure rates. Other than that, there is little consensus on what type of…

Hardware Architecture · Computer Science 2016-11-17 Christof Teuscher , Natali Gulbahce , Thimo Rohlf

We derive a message passing method for computing the spectra of locally tree-like networks and an approximation to it that allows us to compute closed-form expressions or fast numerical approximates for the spectral density of random graphs…

Physics and Society · Physics 2019-04-19 M. E. J. Newman , Xiao Zhang , Raj Rao Nadakuditi

We define a dynamic model of random networks, where new vertices are connected to old ones with a probability proportional to a sublinear function of their degree. We first give a strong limit law for the empirical degree distribution, and…

Probability · Mathematics 2008-07-31 Steffen Dereich , Peter Morters

The alignment between RNA sequences and structures in foundation models (FMs) has yet to be thoroughly investigated. Existing FMs have struggled to establish sequence-structure alignment, hindering the free flow of genomic information…

Genomics · Quantitative Biology 2024-12-16 Heng Yang , Renzhi Chen , Ke Li

In this paper we experiment with using neural network structures to predict a protein's secondary structure ({\alpha} helix positions) from only its primary structure (amino acid sequence). We implement a fully connected neural network…

Machine Learning · Computer Science 2022-08-25 Sidharth Malhotra , Robin Walters

We propose a new topological characterization of RNA secondary structures with pseudoknots based on two topological invariants. Starting from the classic arc-representation of RNA secondary structures, we consider a model that couples both…

Biomolecules · Quantitative Biology 2016-10-19 Graziano Vernizzi , Henri Orland , A. Zee

We discuss the physics of RNA as described by its secondary structure. We examine the static properties of a homogeneous RNA-model that includes pairing and base stacking energies as well as entropic costs for internal loops. For large…

Statistical Mechanics · Physics 2009-11-07 M. Mueller

We present an analytic formalism describing structural properties of random uncorrelated networks with arbitrary degree distributions. The formalism allows to calculate the main network characteristics like: the position of the phase…

Disordered Systems and Neural Networks · Physics 2016-08-31 Agata Fronczak , Piotr Fronczak , Janusz A. Holyst

Accurate prediction of RNA properties, such as stability and interactions, is crucial for advancing our understanding of biological processes and developing RNA-based therapeutics. RNA structures can be represented as 1D sequences, 2D…

Quantitative Methods · Quantitative Biology 2025-04-22 Junjie Xu , Artem Moskalev , Tommaso Mansi , Mangal Prakash , Rui Liao

A random intersection graph is constructed by independently assigning a subset of a given set of objects $W,$ to each vertex of the vertex set $V$ of a simple graph $G.$ There is an edge between two vertices of $V,$ iff their respective…

Probability · Mathematics 2008-09-09 Bhupendra Gupta

Understanding the base pairing of an RNA sequence provides insight into its molecular structure.By mining suboptimal sampling data, RNAprofiling 1.0 identifies the dominant helices in low-energy secondary structures as features, organizes…

Biomolecules · Quantitative Biology 2023-03-29 Forrest Hurley , Christine Heitsch

Dual graphs have been applied to model RNA secondary structures. The purpose of the paper is two-fold: we present new graph-theoretic properties of dual graphs to validate the further analysis and classification of RNAs using these…

Quantitative Methods · Quantitative Biology 2016-01-19 Louis Petingi , Tamar Schlick

Recovering and reconstructing networks by accurately identifying missing and unreliable links is a vital task in the domain of network analysis and mining. In this article, by studying a specific local structure, namely a degree block…

Social and Information Networks · Computer Science 2015-06-19 Zhen Liu , Weike Dong , Yan Fu

Random networks are widely used to model complex networks and research their properties. In order to get a good approximation of complex networks encountered in various disciplines of science, the ability to tune various statistical…

Disordered Systems and Neural Networks · Physics 2009-11-13 Andreas Pusch , Sebastian Weber , Markus Porto

It is the first step for understanding how RNA structure folds from base sequences that to know how its secondary structure is formed. Traditional energy-based algorithms are short of precision, particularly for non-nested sequences, while…

Quantum Physics · Physics 2023-05-18 Ji Jiang , Qipeng Yan , Ye Li , Min Lu , Ziwei Cui , Menghan Dou , Qingchun Wang , Yu-Chun Wu , Guo-Ping Guo

We study the structural constraint of random scale-free networks that determines possible combinations of the degree exponent $\gamma$ and the upper cutoff $k_c$ in the thermodynamic limit. We employ the framework of graphicality…

Statistical Mechanics · Physics 2015-03-20 Yongjoo Baek , Daniel Kim , Meesoon Ha , Hawoong Jeong

Inferring topological characteristics of complex networks from observed data is critical to understand the dynamical behavior of networked systems, ranging from the Internet and the World Wide Web to biological networks and social networks.…

Multiagent Systems · Computer Science 2020-05-13 Chunheng Jiang , Jianxi Gao , Malik Magdon-Ismail

The degree distribution is an important characteristic of complex networks. In many data analysis applications, the networks should be represented as fixed-length feature vectors and therefore the feature extraction from the degree…

Social and Information Networks · Computer Science 2014-07-23 Sadegh Aliakbary , Jafar Habibi , Ali Movaghar

Unified understanding of neuro networks (NNs) gets the users into great trouble because they have been puzzled by what kind of rules should be obeyed to optimize the internal structure of NNs. Considering the potential capability of random…

Machine Learning · Computer Science 2022-01-03 Ruiqi Mao , Rongxin Cui
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