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To make sense of the world around us, we develop models, constructed to enable us to replicate, describe, and explain the behaviours we see. Focusing on the broad case of sequences of correlated random variables, i.e., classical stochastic…

Quantum Physics · Physics 2025-09-04 Paul M. Riechers , Thomas J. Elliott

Researchers develop models to explain the unknowns. These models typically involve parameters that capture tangible quantities, the estimation of which is desired. Parameter identifiability investigates the recoverability of the unknown…

Optimization and Control · Mathematics 2024-07-01 Anuththara Sarathchandra , Azadeh Aghaeeyan , Pouria Ramazi

Structural identifiability concerns the question of which unknown parameters of a model can be recovered from (perfect) input-output data. If all of the parameters of a model can be recovered from data, the model is said to be identifiable.…

Systems and Control · Electrical Eng. & Systems 2025-06-11 Nicolette Meshkat , Alexey Ovchinnikov , Thomas Scanlon

An important problem in biological modeling is choosing the right model. Given experimental data, one is supposed to find the best mathematical representation to describe the real-world phenomena. However, there may not be a unique model…

Dynamical Systems · Mathematics 2024-07-03 Cashous Bortner , Nicolette Meshkat

When employing mechanistic models to study biological phenomena, practical parameter identifiability is important for making accurate predictions across wide range of unseen scenarios, as well as for understanding the underlying mechanisms.…

Quantitative Methods · Quantitative Biology 2023-10-19 Yue Liu , Kevin Suh , Philip K. Maini , Daniel J. Cohen , Ruth E. Baker

The bifactor model and its extensions are multidimensional latent variable models, under which each item measures up to one subdimension on top of the primary dimension(s). Despite their wide applications to educational and psychological…

Statistics Theory · Mathematics 2020-12-23 Guanhua Fang , Xin Xu , Jinxin Guo , Zhiliang Ying , Susu Zhang

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the…

Quantitative Methods · Quantitative Biology 2013-10-07 Marisa C. Eisenberg , Michael A. L. Hayashi

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde

Given experimental data, one of the main objectives of biological modeling is to construct a model which best represents the real world phenomena. In some cases, there could be multiple distinct models exhibiting the exact same dynamics,…

Combinatorics · Mathematics 2024-12-03 Cashous Bortner , John Gilliana , Dev Patel , Zaia Tamras

Linear mixture models have proven very useful in a plethora of applications, e.g., topic modeling, clustering, and source separation. As a critical aspect of the linear mixture models, identifiability of the model parameters is…

Machine Learning · Computer Science 2021-02-24 Bo Yang , Xiao Fu , Nicholas D. Sidiropoulos , Kejun Huang

The successful application of modern machine learning for time series classification is often hampered by limitations in quality and quantity of available training data. To overcome these limitations, available domain expert knowledge in…

Machine Learning · Computer Science 2025-02-07 Janis Norden , Elisa Oostwal , Michael Chappell , Peter Tino , Kerstin Bunte

The parameter identifiability problem for a dynamical system is to determine whether the parameters of the system can be found from data for the outputs of the system. Verifying whether the parameters are identifiable is a necessary first…

Systems and Control · Electrical Eng. & Systems 2025-06-11 Alexey Ovchinnikov , Anand Pillay , Gleb Pogudin , Thomas Scanlon

Mathematical models are invaluable for understanding and predicting how biological systems behave, although their construction requires specifying mechanisms and relationships that are often not perfectly known. In the presence of multiple…

This paper establishes fundamental results for statistical inference of diagnostic classification models (DCM). The results are developed at a high level of generality, applicable to essentially all diagnostic classification models. In…

Statistics Theory · Mathematics 2025-01-08 Guanhua Fang , Jingchen Liu , Zhiliang Ying

We prove identifiability of parameters for a broad class of random graph mixture models. These models are characterized by a partition of the set of graph nodes into latent (unobservable) groups. The connectivities between nodes are…

Statistics Theory · Mathematics 2010-06-07 Elizabeth S. Allman , Catherine Matias , John A. Rhodes

We consider the identifiability theory of probabilistic models and establish sufficient conditions under which the representations learned by a very broad family of conditional energy-based models are unique in function space, up to a…

Machine Learning · Statistics 2020-10-27 Ilyes Khemakhem , Ricardo Pio Monti , Diederik P. Kingma , Aapo Hyvärinen

Diversification models describe the random growth of evolutionary trees, modeling the historical relationships of species through speciation and extinction events. One class of such models allows for independently changing traits, or types,…

Statistics Theory · Mathematics 2022-06-22 Dakota Dragomir , Elizabeth S. Allman , John A. Rhodes

Mixture models have been widely used in modeling of continuous observations. For the possibility to estimate the parameters of a mixture model consistently on the basis of observations from the mixture, identifiability is a necessary…

Probability · Mathematics 2014-07-02 ZiQiang Shi , TieRan Zheng , JiQing Han

Dynamic networks are structured interconnections of dynamical systems (modules) driven by external excitation and disturbance signals. In order to identify their dynamical properties and/or their topology consistently from measured data, we…

Systems and Control · Computer Science 2018-04-12 Harm H. M. Weerts , Paul M. J. Van den Hof , Arne G. Dankers

Latent class models have wide applications in social and biological sciences. In many applications, pre-specified restrictions are imposed on the parameter space of latent class models, through a design matrix, to reflect practitioners'…

Statistics Theory · Mathematics 2019-06-03 Yuqi Gu , Gongjun Xu