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Modern cancer genomics datasets involve widely varying sizes and scales, measurement variables, and correlation structures. A fundamental analytical goal in these high-throughput studies is the development of general statistical techniques…

Methodology · Statistics 2022-04-12 Chiyu Gu , Veerabhadran Baladandayuthapani , Subharup Guha

The spatial organization of the DNA in the cell nucleus plays an important role for gene regulation, DNA replication, and genomic integrity. Through the development of chromosome conformation capture experiments (such as 3C, 4C, Hi-C) it is…

Genomics · Quantitative Biology 2021-01-15 Anastasiya Belyaeva , Kaie Kubjas , Lawrence J. Sun , Caroline Uhler

Integrating heterogeneous datasets across different measurement platforms is a fundamental challenge in many scientific applications. A common example arises in deconvolution problems, such as cell type deconvolution, where one aims to…

Methodology · Statistics 2025-09-30 Dongyue Xie , Lin Gui , Jingshu Wang

In a recent paper Siegfried et al. published a new sequence-based structural RNA assay that utilizes mutational profiling to detect base pairing (MaP). Output from MaP provides information about both pairing (via reactivities) and contact…

Quantitative Methods · Quantitative Biology 2014-12-12 Akshay Tambe , Jennifer Doudna , Lior Pachter

The aim of this work is to classify the aerospace structure defects detected by eddy current non-destructive testing. The proposed method is based on the assumption that the defect is bound to the reaction of the probe coil impedance during…

Computer Vision and Pattern Recognition · Computer Science 2016-10-19 Gianni D'Angelo , Salvatore Rampone

Aircraft maintenance, repair and overhaul industry is gradually switching to 3D scanning for dent inspection. High-accuracy devices allow quick and repeatable measurements, which translate into efficient reporting and more objective damage…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Pasquale Lafiosca , Ip-Shing Fan , Nicolas P. Avdelidis

DNA cytosine methylation is a critical epigenetic mark regulating gene expression and thus playing an important role in development and differentiation across eukaryotes. Existing tools for high-throughput methylation analysis often lack…

Other Quantitative Biology · Quantitative Biology 2025-10-29 Jonas Bucher , Ueli Grossniklaus , Deepak Kumar Tanwar

We introduce a data-driven approach to complete partial 3D shapes through a combination of volumetric deep neural networks and 3D shape synthesis. From a partially-scanned input shape, our method first infers a low-resolution -- but…

Computer Vision and Pattern Recognition · Computer Science 2017-04-13 Angela Dai , Charles Ruizhongtai Qi , Matthias Nießner

We present a novel spatial hashing based data structure to facilitate 3D shape analysis using convolutional neural networks (CNNs). Our method well utilizes the sparse occupancy of 3D shape boundary and builds hierarchical hash tables for…

Graphics · Computer Science 2019-04-19 Tianjia Shao , Yin Yang , Yanlin Weng , Qiming Hou , Kun Zhou

While deep learning methods have achieved impressive success in many vision benchmarks, it remains difficult to understand and explain the representations and decisions of these models. Though vision models are typically trained on 2D…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Benjamin Beilharz , Thomas S. A. Wallis

This paper presents a simple yet powerful method for 3D human mesh reconstruction from a single RGB image. Most recently, the non-local interactions of the whole mesh vertices have been effectively estimated in the transformer while the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-20 Jeonghwan Kim , Mi-Gyeong Gwon , Hyunwoo Park , Hyukmin Kwon , Gi-Mun Um , Wonjun Kim

RGB-based 3D pose estimation methods have been successful with the development of deep learning and the emergence of high-quality 3D pose datasets. However, most existing methods do not operate well for testing images whose distribution is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Hansoo Park , Chanwoo Kim , Jihyeon Kim , Hoseong Cho , Nhat Nguyen Bao Truong , Taehwan Kim , Seungryul Baek

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

In recent years machine learning (ML) took bio- and cheminformatics fields by storm, providing new solutions for a vast repertoire of problems related to protein sequence, structure, and interactions analysis. ML techniques, deep neural…

Biomolecules · Quantitative Biology 2020-03-31 Marta M. Stepniewska-Dziubinska , Piotr Zielenkiewicz , Pawel Siedlecki

In this study, we tested the interaction effect of multimodal datasets using a novel method called the kernel method for detecting higher order interactions among biologically relevant mulit-view data. Using a semiparametric method on a…

Machine Learning · Statistics 2017-07-17 Md. Ashad Alam , Hui-Yi Lin , Vince Calhoun , Yu-Ping Wang

Deep Neural Networks (DNNs) face challenges during deployment due to covariate shift, i.e., data distribution shifts between development and deployment contexts. Fine-tuning adapts pre-trained models to new contexts requiring smaller…

Machine Learning · Computer Science 2025-09-19 Amin Abbasishahkoo , Mahboubeh Dadkhah , Lionel Briand , Dayi Lin

Conventional lithography methods involving pattern transfer through resist templating face challenges of material compatibility with various process solvents. Other approaches of direct material writing often compromise pattern complexity…

Materials Science · Physics 2024-07-19 Shuangshuang Zeng , Tian Tian , Jiwoo Oh , Chih-Jen Shih

Graph neural networks have become a powerful framework for learning complex structure-property relationships and fast screening of chemical compounds. Recently proposed methods have demonstrated that using 3D geometry information of the…

Biomolecules · Quantitative Biology 2022-03-10 Ali Raza , E. Adrian Henle , Xiaoli Fern

Three-dimensional transesophageal echocardiography (3DTEE) is the recommended imaging technique for the assessment of mitral valve (MV) morphology and lesions in case of mitral regurgitation (MR) requiring surgical or transcatheter repair.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Riccardo Munafò , Simone Saitta , Giacomo Ingallina , Paolo Denti , Francesco Maisano , Eustachio Agricola , Alberto Redaelli , Emiliano Votta

We perform a statistical study of the distances between successive occurrencies of a given dinucleotide in the DNA sequence for a number of organisms of different complexity. Our analysis highlights peculiar features of the dinucleotide CG…

Quantitative Methods · Quantitative Biology 2016-04-27 Giulia Paci , Giampaolo Cristadoro , Barbara Monti , Marco Lenci , Mirko Degli Esposti , Gastone C. Castellani , Daniel Remondini