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Molecular noise in gene regulatory networks has two intrinsic components, one part being due to fluctuations caused by the birth and death of protein or mRNA molecules which are often present in small numbers and the other part arising from…

Molecular Networks · Quantitative Biology 2015-11-17 Davit A. Potoyan , Peter G. Wolynes

Recent research has provided a wealth of evidence highlighting the pivotal role of high-order interdependencies in supporting the information-processing capabilities of distributed complex systems. These findings may suggest that high-order…

Adaptation and Self-Organizing Systems · Physics 2023-05-24 Patricio Orio , Pedro A. M. Mediano , Fernando E. Rosas

Recent advances in associative memory design through structured pattern sets and graph-based inference algorithms have allowed reliable learning and recall of an exponential number of patterns. Although these designs correct external errors…

Neural and Evolutionary Computing · Computer Science 2014-03-14 Amin Karbasi , Amir Hesam Salavati , Amin Shokrollahi , Lav R. Varshney

We study the steady state properties of a genotype selection model in presence of correlated Gaussian white noise. The effect of the noise on the genotype selection model is discussed. It is found that correlated noise can break the balance…

Biological Physics · Physics 2018-01-17 Bao-Quan Ai , Wei Chen , Xian-Ju Wang , Guo-Tao Liu , De-Hua Wen , Liang-Gang Liu

How intelligence arises from the brain is a central problem in science. A crucial aspect of intelligence is dealing with uncertainty -- developing good predictions about one's environment, and converting these predictions into decisions.…

Neurons and Cognition · Quantitative Biology 2024-06-13 Max Dabagia , Daniel Mitropolsky , Christos H. Papadimitriou , Santosh S. Vempala

A new class of energy-efficient digital microprocessor is being developed which is susceptible to thermal noise and consequently operates in probabilistic rather than conventional deterministic mode. Hybrid computing systems which combine…

Neurons and Cognition · Quantitative Biology 2014-12-17 T. N. Palmer , M. O'Shea

Learning and decision making in the brain are key processes critical to survival, and yet are processes implemented by non-ideal biological building blocks which can impose significant error. We explore quantitatively how the brain might…

Neurons and Cognition · Quantitative Biology 2011-04-19 Jake Bouvrie , Jean-Jacques Slotine

It is well-known that gene activation/deactivation dynamics may be a major source of randomness in genetic networks, also in the case of large concentrations of the transcription factors. In this work, we investigate the effect of realistic…

Molecular Networks · Quantitative Biology 2014-10-28 Sebastiano de Franciscis , Giulio Caravagna , Alberto d'Onofrio

Living systems implement and execute an extraordinary plethora of computational tasks. The inherent degree of large scale coordination emerges as a global property, from the intricate sea of microscopic interactions. The brain, with its…

Disordered Systems and Neural Networks · Physics 2018-01-03 Duccio Fanelli , Francesco Ginelli , Roberto Livi , Niccolò Zagli , Clement Zankoc

We investigate the problem of designing optimal classifiers in the strategic classification setting, where the classification is part of a game in which players can modify their features to attain a favorable classification outcome (while…

Machine Learning · Computer Science 2020-05-19 Mark Braverman , Sumegha Garg

Several experimental studies claim to be able to predict the outcome of simple decisions from brain signals measured before subjects are aware of their decision. Often, these studies use multivariate pattern recognition methods with the…

Neurons and Cognition · Quantitative Biology 2016-06-21 Marco Rusconi , Angelo Valleriani

Varied sensory systems use noise in order to enhance detection of weak signals. It has been conjectured in the literature that this effect, known as stochastic resonance, may take place in central cognitive processes such as the memory…

Neurons and Cognition · Quantitative Biology 2007-05-23 Julien Mayor , Wulfram Gerstner

Humans and other animals base their decisions on noisy sensory input. Much work has therefore been devoted to understanding the computations that underly such decisions. The problem has been studied in a variety of tasks and with stimuli of…

Neurons and Cognition · Quantitative Biology 2015-03-05 Manisha Bhardwaj , Sam Carroll , Wei Ji Ma , Kresimir Josic

Artificial Intelligence has historically relied on planning, heuristics, and handcrafted approaches designed by experts. All the while claiming to pursue the creation of Intelligence. This approach fails to acknowledge that intelligence…

Neural and Evolutionary Computing · Computer Science 2020-03-27 Jordan Ott

Gene regulatory networks can be successfully modeled as Boolean networks. A much discussed hypothesis says that such model networks reproduce empirical findings the best if they are tuned to operate at criticality, i.e. at the borderline…

Molecular Networks · Quantitative Biology 2016-10-12 Pablo Villegas , José Ruiz-Franco , Jorge Hidalgo , Miguel A. Muñoz

Multipotent differentiation, where cells adopt one of several cell fates, is a determinate and orchestrated procedure that often incorporates stochastic mechanisms in order to diversify cell types. How these stochastic phenomena interact to…

Cell Behavior · Quantitative Biology 2015-03-09 Andreas I. Reppas , Georgios Lolas , Andreas Deutsch , Haralampos Hatzikirou

In this paper machine learning and artificial neural network models are proposed for the classification of external noise sources affecting a given quantum dynamics. For this purpose, we train and then validate support vector machine,…

Quantum Physics · Physics 2023-02-17 Stefano Martina , Stefano Gherardini , Filippo Caruso

In simple perceptual decisions the brain has to identify a stimulus based on noisy sensory samples from the stimulus. Basic statistical considerations state that the reliability of the stimulus information, i.e., the amount of noise in the…

Neurons and Cognition · Quantitative Biology 2015-09-08 Sebastian Bitzer , Stefan J. Kiebel

The presence of noise in non linear dynamical systems can play a constructive role, increasing the degree of order and coherence or evoking improvements in the performance of the system. An example of this positive influence in a biological…

Dynamical Systems · Mathematics 2016-09-07 M. -P. Zorzano , L. Vazquez

We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate. Can such spatial coupling be of benefit for conveying…

Molecular Networks · Quantitative Biology 2015-01-19 Thomas R. Sokolowski , Gašper Tkačik