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Generalized Estimation Equations (GEE) are a well-known method for the analysis of categorical longitudinal responses. GEE method has computational simplicity and population parameter interpretation. In the presence of missing data it is…

Methodology · Statistics 2015-06-16 José Luiz P. da Silva , Enrico A. Colosimo , Fábio N. Demarqui

Generalized Estimation Equations (GEE) are a well-known method for the analysis of non-Gaussian longitudinal data. This method has computational simplicity and marginal parameter interpretation. However, in the presence of missing data, it…

Methodology · Statistics 2015-06-16 José Luiz P. da Silva , Enrico A. Colosimo , Fábio N. Demarqui

In clinical trials involving paired organs such as eyes, ears, and kidneys, binary outcomes may be collected bilaterally or unilaterally. In such combined datasets, bilateral outcomes exhibit intra-subject correlation, while unilateral…

Methodology · Statistics 2025-08-19 Jia Zhou , Chang-Xing Ma

Generalized estimating equation (GEE) is widely adopted for regression modeling for longitudinal data, taking account of potential correlations within the same subjects. Although the standard GEE assumes common regression coefficients among…

Methodology · Statistics 2022-07-11 Tsubasa Ito , Shonosuke Sugasawa

Generalized estimating equations (GEE; Liang & Zeger 1986) for general vector regression settings are examined. When the response vectors are of mixed type (e.g. continuous-binary response pairs), the GEE approach is a semiparametric…

Methodology · Statistics 2020-10-08 Alan Huang

We describe the R package MOODE and demonstrate its use to find multi-objective optimal experimental designs. Multi-Objective Optimal Design of Experiments (MOODE) targets the experimental objectives directly, ensuring that the full set of…

Computation · Statistics 2024-12-24 Vasiliki Koutra , Olga Egorova , Steven G. Gilmour , Luzia A. Trinca

We describe the \proglang{R} package \pkg{glmmrBase} and an extension \pkg{glmmrOptim}. \pkg{glmmrBase} provides a flexible approach to specifying, fitting, and analysing generalised linear mixed models. We use an object-orientated class…

Computation · Statistics 2024-03-15 Samuel I. Watson

Extending generalized estimating equations (GEE) to ordinal response data requires a conversion of the ordinal response to a vector of binary category indicators. That leads to a rather complicated association structure, and the…

Methodology · Statistics 2017-05-23 Aristidis K. Nikoloulopoulos

robustloggamma is an R package for robust estimation and inference in the generalized loggamma model. We briefly introduce the model, the estimation procedures and the computational algorithms. Then, we illustrate the use of the package…

Computation · Statistics 2015-12-08 Claudio Agostinelli , Alfio Marazzi , Victor J. Yohai , Alex Randriamiharisoa

We present R package mnlogit for training multinomial logistic regression models, particularly those involving a large number of classes and features. Compared to existing software, mnlogit offers speedups of 10x-50x for modestly sized…

Computation · Statistics 2014-09-17 Asad Hasan , Wang Zhiyu , Alireza S. Mahani

Originally introduced as a neural network for ensemble learning, mixture of experts (MoE) has recently become a fundamental building block of highly successful modern deep neural networks for heterogeneous data analysis in several…

Machine Learning · Statistics 2024-02-12 Huy Nguyen , TrungTin Nguyen , Khai Nguyen , Nhat Ho

ProfileGLMM is an R package integrating Generalised Linear Mixed Models (GLMMs) as the outcome model for Bayesian profile regression. This statistical framework simultaneously i) explains the variation in the outcome and ii) clusters the…

Methodology · Statistics 2026-04-23 Matteo Amestoy , Mark A. van de Wiel , Wessel N. van Wieringen

The R package lcmm provides a series of functions to estimate statistical models based on linear mixed model theory. It includes the estimation of mixed models and latent class mixed models for Gaussian longitudinal outcomes (hlme),…

Computation · Statistics 2017-08-24 Cécile Proust-Lima , Viviane Philipps , Benoit Liquet

We present a new open source implementation in the SageMath computer algebra system of algorithms for the numerical solution of linear ODEs with polynomial coefficients. Our code supports regular singular connection problems and provides…

Symbolic Computation · Computer Science 2016-07-08 Marc Mezzarobba

The cgam package contains routines to fit the generalized additive model where the components may be modeled with shape and smoothness assumptions. The main routine is cgam and nineteen symbolic routines are provided to indicate the…

Applications · Statistics 2018-12-20 Xiyue Liao , Mary C. Meyer

The method of generalized estimating equations (GEE) is popular in the biostatistics literature for analyzing longitudinal binary and count data. It assumes a generalized linear model (GLM) for the outcome variable, and a working…

Methodology · Statistics 2016-06-03 Aristidis K. Nikoloulopoulos

Generalized estimating equations (GEE) are of great importance in analyzing clustered data without full specification of multivariate distributions. A recent approach jointly models the mean, variance, and correlation coefficients of…

Methodology · Statistics 2025-01-13 Zhenyu Xu , Jason P. Fine , Wenling Song , Jun Yan

Joint models for longitudinal and time-to-event data constitute an attractive modeling framework that has received a lot of interest in the recent years. This paper presents the capabilities of the R package JMbayes for fitting these models…

Computation · Statistics 2014-05-01 Dimitris Rizopoulos

The Generalized Estimating Equations (GEE) approach is a widely used statistical method for analyzing longitudinal data and clustered data in clinic studies. In dentistry, due to multiple outcomes obtained from one patient, the outcomes…

Methodology · Statistics 2025-02-25 Hoi-Jeong Lim , Soo-Hyeon Park

Modeling correlated or highly stratified multiple-response data becomes a common data analysis task due to modern data monitoring facilities and methods. Generalized estimating equations (GEE) is one of the popular statistical methods for…

Methodology · Statistics 2019-03-05 Zimu Chen , Zhanfeng Wang , Yuan-chin Ivan Chang
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