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We study a simple model of DNA evolution in a growing population of cells. Each cell contains a nucleotide sequence which randomly mutates at cell division. Cells divide according to a branching process. Following typical parameter values…

Probability · Mathematics 2020-06-05 David Cheek , Tibor Antal

We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and…

adap-org · Physics 2009-10-31 Erik van Nimwegen , James P. Crutchfield , Martijn Huynen

We consider a single genetic locus with two alleles $A_1$ and $A_2$ in a large haploid population. The locus is subject to selection and two-way, or recurrent, mutation. Assuming the allele frequencies follow a Wright-Fisher diffusion and…

Probability · Mathematics 2024-04-29 Wai-Tong Louis Fan , John Wakeley

The distribution and heritability of many traits depends on numerous loci in the genome. In general, the astronomical number of possible genotypes makes the system with large numbers of loci difficult to describe. Multilocus evolution,…

Populations and Evolution · Quantitative Biology 2012-08-01 Richard A. Neher , Boris I. Shraiman

We present an individual based model of evolutionary ecology. The reproduction rate of individuals characterized by their genome depends on the composition of the population in genotype space. Ecological features such as the taxonomy and…

Statistical Mechanics · Physics 2016-08-31 Matt Hall , Kim Christensen , Simone A. di Collobiano , Henrik Jeldtoft Jensen

We investigate the behavior of a population genetics model introduced by Waxman and Peck incorporating mutation, selection, and pleiotropy. The population is infinite and continuous variation of genotype is allowed. Nonetheless, Waxman and…

Condensed Matter · Physics 2015-06-25 S. N. Coppersmith , Robert D. Blank , Leo P. Kadanoff

We examine the switching dynamics of a stochastic population subjected to a deterministically time-varying environment. Our approach is demonstrated in the realm of ecology on a problem of population establishment. Here, by assuming a…

Statistical Mechanics · Physics 2020-02-19 Tom Israeli , Michael Assaf

We are interested in the impact of natural selection in a prey-predator community. We introduce an individual-based model of the community that takes into account both prey and predator phenotypes. Our aim is to understand the phenotypic…

Populations and Evolution · Quantitative Biology 2015-02-19 Manon Costa , Céline Hauzy , Nicolas Loeuille , Sylvie Méléard

Background: Acceleration of adaptation dynamics by stress-induced hypermutation has been found experimentally. Evolved evolvability is a prominent explanation. We investigate a more generally applicable explanation by a physical constraint.…

Biological Physics · Physics 2011-04-12 Lennart Hilbert

In this paper, we review recent results of ours concerning branching processes with general lifetimes and neutral mutations, under the infinitely many alleles model, where mutations can occur either at birth of individuals or at a constant…

Probability · Mathematics 2012-11-29 Nicolas Champagnat , Amaury Lambert , Mathieu Richard

The dynamic theory of inhomogeneous populations developed during the last decade predicts several essential new dynamic regimes applicable even to the well-known, simple population models. We show that, in an inhomogeneous population with a…

Populations and Evolution · Quantitative Biology 2007-05-23 Georgy P. Karev

Genetic and evolution algebras arise naturally from applied probability and stochastic processes. Gibbs measures describe interacting systems commonly studied in thermodynamics and statistical mechanics with applications in several fields.…

Mathematical Physics · Physics 2025-05-05 Cristian F. Coletti , Lucas R. de Lima , Denis A. Luiz

The deterministic selection-recombination equation describes the evolution of the genetic type composition of a population under selection and recombination in a law of large numbers regime. So far, an explicit solution has seemed out of…

Probability · Mathematics 2023-04-26 Ellen Baake , Frederic Alberti

We consider the discrete-time migration-recombination equation, a deterministic, nonlinear dynamical system that describes the evolution of the genetic type distribution of a population evolving under migration and recombination in a law of…

Probability · Mathematics 2021-03-30 Frederic Alberti , Ellen Baake , Ian Letter , Servet Martinez

Species diversity in ecosystems is often accompanied by the self-organisation of the population into fascinating spatio-temporal patterns. Here, we consider a two-dimensional three-species population model and study the spiralling patterns…

Populations and Evolution · Quantitative Biology 2013-05-09 Bartosz Szczesny , Mauro Mobilia , Alastair M. Rucklidge

To understand the effect of assortative mating on the genetic evolution of a population, we consider a finite population in which each individual has a type, determined by a sequence of n diallelic loci. We assume that the population…

Probability · Mathematics 2023-11-30 Alison M. Etheridge , Sophie Lemaire

Many imaging techniques for biological systems -- like fixation of cells coupled with fluorescence microscopy -- provide sharp spatial resolution in reporting locations of individuals at a single moment in time but also destroy the dynamics…

Subcellular Processes · Quantitative Biology 2024-05-15 Christopher E. Miles , Scott A. McKinley , Fangyuan Ding , Richard B. Lehoucq

We present a general framework to describe the evolutionary dynamics of an arbitrary number of types in finite populations based on stochastic differential equations (SDE). For large, but finite populations this allows to include…

Populations and Evolution · Quantitative Biology 2012-06-13 Arne Traulsen , Jens Christian Claussen , Christoph Hauert

We study the evolutionary dynamics of a phenotypically structured population in a changing environment , where the environmental conditions vary with a linear trend but in an oscillatory manner. Such phenomena can be described by parabolic…

Analysis of PDEs · Mathematics 2021-05-04 Susely Figueroa Iglesias , Sepideh Mirrahimi

We first recall some basic facts from the theory of discrete-time Markov chains arising from two types neutral and non-neutral evolution models of population genetics with constant size. We then define and analyse a version of such models…

Populations and Evolution · Quantitative Biology 2017-03-09 Nicolas Grosjean , Thierry Huillet
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