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Mass spectrometry (MS) is an important technique for chemical profiling which calculates for a sample a high dimensional histogram-like spectrum. A crucial step of MS data processing is the peak picking which selects peaks containing…

Machine Learning · Statistics 2009-10-05 Theodore Alexandrov , Klaus Steinhorst , Oliver Keszoecze , Stefan Schiffler

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Magnetic resonance imaging (MRI) is indispensable for diagnosing and planning treatment in various medical conditions due to its ability to produce multi-series images that reveal different tissue characteristics. However, integrating these…

Image and Video Processing · Electrical Eng. & Systems 2024-12-11 Churan Wang , Fei Gao , Lijun Yan , Siwen Wang , Yizhou Yu , Yizhou Wang

For multi-modal magnetic resonance (MR) brain tumor image segmentation, current methods usually directly extract the discriminative features from input images for tumor sub-region category determination and localization. However, the impact…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Yafei Zhang , Zhiyuan Li , Huafeng Li , Dapeng Tao

We present a novel approach to implement compressive sensing in laser scanning microscopes (LSM), specifically in image scanning microscopy (ISM), using a single-photon avalanche diode (SPAD) array detector. Our method addresses two…

Image and Video Processing · Electrical Eng. & Systems 2023-07-20 Ajay Gunalan , Marco Castello , Simonluca Piazza , Shunlei Li , Alberto Diaspro , Leonardo S. Mattos , Paolo Bianchini

While state-of-the-art models for breast cancer detection leverage multi-view mammograms for enhanced diagnostic accuracy, they often focus solely on visual mammography data. However, radiologists document valuable lesion descriptors that…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Gil Ben-Artzi , Feras Daragma , Shahar Mahpod

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

The inclusion of spatial information into spectral classifiers for fine-resolution hyperspectral imagery has led to significant improvements in terms of classification performance. The task of spectral-spatial hyperspectral image…

Computer Vision and Pattern Recognition · Computer Science 2021-09-08 Puhong Duan , Pedram Ghamisi , Xudong Kang , Behnood Rasti , Shutao Li , Richard Gloaguen

Multimodal medical image fusion (MMIF) aims to integrate images from different modalities to produce a comprehensive image that enhances medical diagnosis by accurately depicting organ structures, tissue textures, and metabolic information.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Tao Luo , Weihua Xu

The analysis of data streams has received considerable attention over the past few decades due to sensors, social media, etc. It aims to recognize patterns in an unordered, infinite, and evolving stream of observations. Clustering this type…

Machine Learning · Computer Science 2022-01-14 Mohammed Oualid Attaoui , Hanene Azzag , Mustapha Lebbah , Nabil Keskes

The classification of histopathological images is of great value in both cancer diagnosis and pathological studies. However, multiple reasons, such as variations caused by magnification factors and class imbalance, make it a challenging…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Yibao Sun , Xingru Huang , Yaqi Wang , Huiyu Zhou , Qianni Zhang

Model-based clustering is widely used for identifying and distinguishing types of diseases. However, modern biomedical data coming with high dimensions make it challenging to perform the model estimation in traditional cluster analysis. The…

Methodology · Statistics 2025-07-22 Kazeem Kareem , Fan Dai

Multiple sclerosis (MS) is a demyelinating disease that affects more than 2 million people worldwide. The most used imaging technique to help in its diagnosis and follow-up is magnetic resonance imaging (MRI). Fluid Attenuated Inversion…

Computer Vision and Pattern Recognition · Computer Science 2018-07-26 Paulo G. L. Freire , Ricardo J. Ferrari

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

Quantitative characterization of cellular spatial organization is critical for understanding tumor progression and immune response. Recent advances in artificial intelligence (AI) enable large-scale segmentation and classification of nuclei…

Liquid Chromatography coupled to Mass Spectrometry (LC-MS) based methods are commonly used for high-throughput, quantitative measurements of the proteome (i.e. the set of all proteins in a sample at a given time). Targeted LC-MS produces…

Computer Vision and Pattern Recognition · Computer Science 2020-10-28 Leon L. Xu , Hannes L. Röst

Laser Ablation Electrospray Ionization is a recent development in mass spectrometry imaging. It has been shown that lipids and small metabolites can be imaged in various samples such as plant material, tissue sections or bacterial colonies…

Biological Physics · Physics 2013-09-05 András Kiss , Donald F. Smith , Brent R. Reschke , Matthew J. Powell , Ron M. A. Heeren

Referring image segmentation (RIS) is a fundamental vision-language task that intends to segment a desired object from an image based on a given natural language expression. Due to the essentially distinct data properties between image and…

Computer Vision and Pattern Recognition · Computer Science 2024-02-15 Wenxuan Wang , Jing Liu , Xingjian He , Yisi Zhang , Chen Chen , Jiachen Shen , Yan Zhang , Jiangyun Li