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Generalized linear mixed-effects models (GLMMs) are widely used to analyze grouped and hierarchical data. In a GLMM, each response is assumed to follow an exponential-family distribution where the natural parameter is given by a linear…

Machine Learning · Statistics 2026-04-14 Yuli Slavutsky , Sebastian Salazar , David M. Blei

Motivated by genome-wide association studies, we consider a standard linear model with one additional random effect in situations where many predictors have been collected on the same subjects and each predictor is analyzed separately.…

Applications · Statistics 2013-04-24 Matti Pirinen , Peter Donnelly , Chris C. A. Spencer

Two linearly uncorrelated binary variables must be also independent because non-linear dependence cannot manifest with only two possible states. This inherent linearity is the atom of dependency constituting any complex form of…

Statistics Theory · Mathematics 2025-07-01 Benjamin Brown , Kai Zhang , Xiao-Li Meng

Large Language Models (LLMs) and causal learning each hold strong potential for clinical decision making (CDM). However, their synergy remains poorly understood, largely due to the lack of systematic benchmarks evaluating their integration…

Machine Learning · Computer Science 2025-11-14 Linna Wang , Zhixuan You , Qihui Zhang , Jiunan Wen , Ji Shi , Yimin Chen , Yusen Wang , Fanqi Ding , Ziliang Feng , Li Lu

We consider the problems of variable selection and estimation in nonparametric additive regression models for high-dimensional data. In recent years, several methods have been proposed to model nonlinear relationships when the number of…

Methodology · Statistics 2013-10-07 Linn Cecilie Bergersen , Kukatharmini Tharmaratnam , Ingrid K. Glad

Difference in differences (DD) is widely used to find policy/treatment effects with observational data, but applying DD to limited dependent variables (LDV's) Y has been problematic. This paper addresses how to apply DD and related…

Econometrics · Economics 2023-08-15 Myoung-jae Lee , Sanghyeok Lee

Competing risk analysis considers event times due to multiple causes, or of more than one event types. Commonly used regression models for such data include 1) cause-specific hazards model, which focuses on modeling one type of event while…

Applications · Statistics 2017-04-27 Jiayi Hou , Anthony Paravati , Ronghui Xu , James Murphy

Reduced rank regression (RRR) is a widely employed model for investigating the linear association between multiple response variables and a set of predictors. While RRR has been extensively explored in various works, the focus has…

Statistics Theory · Mathematics 2024-04-30 The Tien Mai

While several Gaussian mixture models-based biclustering approaches currently exist in the literature for continuous data, approaches to handle discrete data have not been well researched. A multivariate Poisson-lognormal (MPLN) model-based…

Methodology · Statistics 2025-03-13 Caitlin Kral , Evan Chance , Ryan Browne , Sanjeena Subedi

This paper establishes bounds on the performance of empirical risk minimization for large-dimensional linear regression. We generalize existing results by allowing the data to be dependent and heavy-tailed. The analysis covers both the…

Econometrics · Economics 2025-04-23 Christian Brownlees , Guðmundur Stefán Guðmundsson

In many supervised learning tasks, the entities to be labeled are related to each other in complex ways and their labels are not independent. For example, in hypertext classification, the labels of linked pages are highly correlated. A…

Machine Learning · Computer Science 2013-01-07 Ben Taskar , Pieter Abbeel , Daphne Koller

We develop methodology for causal inference in observational studies when using propensity score subclassification on data constructed with probabilistic record linkage techniques. We focus on scenarios where covariates and binary treatment…

Methodology · Statistics 2018-04-03 Joan Heck Wortman , Jerome P. Reiter

The shape of the relationship between a continuous exposure variable and a binary disease variable is often central to epidemiologic investigations. This paper investigates a number of issues surrounding inference and the shape of the…

Methodology · Statistics 2019-02-01 Li Xing , Xuekui Zhang , Igor Burstyn , Paul Gustafson

Understanding the dependence structure between response variables is an important component in the analysis of correlated multivariate data. This article focuses on modeling dependence structures in multivariate binary data, motivated by a…

Methodology · Statistics 2024-12-18 Zhi Yang Tho , Francis K. C. Hui , Tao Zou

In this paper we consider exact tests of a multiple logistic regression, where the levels of covariates are equally spaced, via Markov beses. In usual application of multiple logistic regression, the sample size is positive for each…

Statistics Theory · Mathematics 2010-02-18 Hisayuki Hara , Akimichi Takemura , Ruriko Yoshida

For high-dimensional linear regression models, we review and compare several estimators of variances $\tau^2$ and $\sigma^2$ of the random slopes and errors, respectively. These variances relate directly to ridge regression penalty…

Computation · Statistics 2019-02-08 Jurre R. Veerman , Gwenael G. R. Leday , Mark A. van de Wiel

Semiparametric regression offers a flexible framework for modeling non-linear relationships between a response and covariates. A prime example are generalized additive models where splines (say) are used to approximate non-linear functional…

Statistics Theory · Mathematics 2018-10-05 Francis K. C. Hui , Chong You , Han Lin Shang , Samuel Müller

In survival studies it is important to record the values of key longitudinal covariates until the occurrence of event of a subject. For this reason, it is essential to study the association between longitudinal and time-to-event outcomes…

Methodology · Statistics 2021-06-09 Khandoker Akib Mohammad , Yuichi Hirose , Yuan Yao , Budhi Surya

Applied work often studies the effect of a binary variable ("treatment") using linear models with additive effects. I study the interpretation of the OLS estimands in such models when treatment effects are heterogeneous. I show that the…

Econometrics · Economics 2020-05-21 Tymon Słoczyński

The logistic regression model is known to converge to a Poisson point process model if the binary response tends to infinitely imbalanced. In this paper, it is shown that this phenomenon is universal in a wide class of link functions on…

Statistics Theory · Mathematics 2013-04-23 Tomonari Sei