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We describe a new, computationally simple method for analyzing the dynamics of neuronal spike trains driven by external stimuli. The goal of our method is to test the predictions of simple spike-generating models against extracellularly…

Neurons and Cognition · Quantitative Biology 2007-05-23 Daniel S. Reich , Jonathan D. Victor , Bruce W. Knight

This article contains two main theoretical results on neural spike train models. The first assumes that the spike train is modeled as a counting or point process on the real line where the conditional intensity function is a product of a…

Statistics Theory · Mathematics 2007-06-13 Hock Peng Chan , Wei-Liem Loh

We wish to discriminate spike sequences based on the degree of irregularity. For this purpose, we search for a rational expressions of quadratic functions of consecutive interspike intervals that efficiently measures spiking irregularity.…

Neurons and Cognition · Quantitative Biology 2007-05-23 K. Miura , M. Okada , S. Shinomoto

Statistical properties of spike trains measured from a sensory neuron in-vivo are studied experimentally and theoretically. Experiments are performed on an identified neuron in the visual system of the blowfly. It is shown that the spike…

Biological Physics · Physics 2007-05-23 N. Brenner , O. Agam , W. Bialek , R. de Ruyter van Steveninck

Neural noise sets a limit to information transmission in sensory systems. In several areas, the spiking response (to a repeated stimulus) has shown a higher degree of regularity than predicted by a Poisson process. However, a simple model…

Neurons and Cognition · Quantitative Biology 2018-01-08 Ulisse Ferrari , Stephane Deny , Olivier Marre , Thierry Mora

Accurate statistical models of neural spike responses can characterize the information carried by neural populations. But the limited samples of spike counts during recording usually result in model overfitting. Besides, current models…

Quantitative Methods · Quantitative Biology 2021-06-17 Qi She , Xiaoli Wu , Beth Jelfs , Adam S. Charles , Rosa H. M. Chan

Spike generation in neurons produces a temporal point process, whose statistics is governed by intrinsic phenomena and the external incoming inputs to be coded. In particular, spike-evoked adaptation currents support a slow temporal process…

Neurons and Cognition · Quantitative Biology 2016-10-31 Eugenio Urdapilleta

Neuroscientists have worked on the problem of estimating synaptic properties, such as connectivity and strength, from simultaneously recorded spike trains since the 1960s. Recent years have seen renewed interest in the problem, coinciding…

Neurons and Cognition · Quantitative Biology 2024-05-07 Zach Saccomano , Sam Mckenzie , Horacio Rotstein , Asohan Amarasingham

Recently, the SPIKE-distance has been proposed as a parameter-free and time-scale independent measure of spike train synchrony. This measure is time-resolved since it relies on instantaneous estimates of spike train dissimilarity. However,…

Data Analysis, Statistics and Probability · Physics 2012-12-11 Thomas Kreuz , Daniel Chicharro , Conor Houghton , Ralph G Andrzejak , Florian Mormann

We construct a model that predicts the statistical properties of spike trains generated by a sensory neuron. The model describes the combined effects of the neuron's intrinsic properties, the noise in the surrounding, and the external…

Biological Physics · Physics 2009-10-31 N. Brenner , O. Agam , W. Bialek , R. de Ruyter van Steveninck

In this paper we consider the problem of detecting statistically significant sequential patterns in multi-neuronal spike trains. These patterns are characterized by ordered sequences of spikes from different neurons with specific delays…

Neurons and Cognition · Quantitative Biology 2008-08-28 P. S. Sastry , K. P. Unnikrishnan

Fluctuation scaling has been observed universally in a wide variety of phenomena. In time series that describe sequences of events, fluctuation scaling is expressed as power function relationships between the mean and variance of either…

Data Analysis, Statistics and Probability · Physics 2015-11-03 Shinsuke Koyama , Ryota Kobayashi

At the single-neuron level, precisely timed spikes can either constitute firing-rate codes or spike-pattern codes that utilize the relative timing between consecutive spikes. There has been little experimental support for the hypothesis…

Neurons and Cognition · Quantitative Biology 2009-12-18 Hugo Gabriel Eyherabide , Ariel Rokem , Andreas V. M. Herz , Ines Samengo

Spiking activity in cortical networks is nonlinear in nature. The linear-nonlinear cascade model, some versions of which are also known as point-process generalized linear model, can efficiently capture the nonlinear dynamics exhibited by…

Neurons and Cognition · Quantitative Biology 2020-01-16 Michael Kordovan , Stefan Rotter

Modeling spike firing assumes that spiking statistics are Poisson, but real data violates this assumption. To capture non-Poissonian features, in order to fix the inevitable inherent irregularity, researchers rescale the time axis with…

Neural and Evolutionary Computing · Computer Science 2013-03-06 M. A. El-Dosuky , M. Z. Rashad , T. T. Hamza , A. H. EL-Bassiouny

Estimating the degree of synchrony or reliability between two or more spike trains is a frequent task in both experimental and computational neuroscience. In recent years, many different methods have been proposed that typically compare the…

Biological Physics · Physics 2012-12-11 Thomas Kreuz , Julie S. Haas , Alice Morelli , Henry D. I. Abarbanel , Antonio Politi

We address the problem of identifying functional interactions among stochastic neurons with variable-length memory from their spiking activity. The neuronal network is modeled by a stochastic system of interacting point processes with…

Applications · Statistics 2025-07-01 Ricardo F. Ferreira , Matheus E. Pacola , Vitor G. Schiavone , Rodrigo F. O. Pena

Advances in neuroscience have enabled researchers to measure the activities of large numbers of neurons simultaneously in behaving animals. We have access to the fluorescence of each of the neurons which provides a first-order approximation…

Neurons and Cognition · Quantitative Biology 2023-07-21 Abhisek Chakraborty

We present the mathematical basis of a new approach to the analysis of temporal coding. The foundation of the approach is the construction of several families of novel distances (metrics) between neuronal impulse trains. In contrast to most…

Neurons and Cognition · Quantitative Biology 2007-05-23 Jonathan D. Victor , Keith P. Purpura

Statistical analysis and inferences on spike trains are one of the central topics in neural coding. It is of great interest to understand the underlying distribution and geometric structure of given spike train data. However, a fundamental…

Neurons and Cognition · Quantitative Biology 2015-06-11 Sergiusz Wesolowski , Alexandre A. Nikonov , Robert J. Contreras , Wei Wu
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