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It is now established that nuclear quantum motion plays an important role in determining water's hydrogen bonding, structure, and dynamics. Such effects are important to include in density functional theory (DFT) based molecular dynamics…

Chemical Physics · Physics 2018-12-20 Daniel C. Elton , Michelle Fritz , M. -V. Fernández-Serra

The interaction of condensed phase systems with external electric fields is crucial in myriad processes in nature and technology ranging from the field-directed motion of cells (galvanotaxis), to energy storage and conversion systems…

Chemical Physics · Physics 2024-09-25 Kit Joll , Philipp Schienbein , Kevin M. Rosso , Jochen Blumberger

An optical neural network (ONN) is a promising system due to its high-speed and low-power operation. Its linear unit performs a multiplication of an input vector and a weight matrix in optical analog circuits. Among them, a circuit with a…

Machine Learning · Computer Science 2021-09-07 Kazuo Aoyama , Hiroshi Sawada

Linear scaling methods for density-functional theory (DFT) simulations are formulated in terms of localised orbitals in real-space, rather than the delocalised eigenstates of conventional approaches. In local-orbital methods, relative to…

Materials Science · Physics 2011-05-30 N. D. M. Hine , M. Robinson , P. D. Haynes , C. -K. Skylaris , M. C. Payne , A. A. Mostofi

Time series are ubiquitous in domains ranging from medicine to marketing and finance. Frequent Pattern Mining (FPM) from a time series has thus received much attention. Recently, it has been studied under the order-preserving (OP) matching…

Data Structures and Algorithms · Computer Science 2024-12-02 Ling Li , Wiktor Zuba , Grigorios Loukides , Solon P. Pissis , Maria Matsangidou

The implementation of Molecular Dynamics (MD) on FPGAs has received substantial attention. Previous work, however, has consisted of either proof-of-concept implementations of components, usually the range-limited force; full systems, but…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-15 Chen Yang , Tong Geng , Tianqi Wang , Rushi Patel , Qingqing Xiong , Ahmed Sanaullah , Jiayi Sheng , Charles Lin , Vipin Sachdeva , Woody Sherman , Martin C. Herbordt

Nonnegative matrix factorization (NMF) has been shown to be identifiable under the separability assumption, under which all the columns(or rows) of the input data matrix belong to the convex cone generated by only a few of these columns(or…

Machine Learning · Statistics 2014-03-25 Jason Gejie Liu , Shuchin Aeron

Machine learning force fields have emerged as promising tools for molecular dynamics (MD) simulations, potentially offering quantum-mechanical accuracy with the efficiency of classical MD. Inspired by foundational large language models,…

Computational Physics · Physics 2025-11-14 Denan Li , Jiyuan Yang , Xiangkai Chen , Lintao Yu , Shi Liu

While several numerical techniques are available for predicting the dynamics of non-Markovian open quantum systems, most struggle with simulations for very long memory and propagation times, e.g., due to superlinear scaling with the number…

Quantum Physics · Physics 2025-05-01 Moritz Cygorek , Jonathan Keeling , Brendon W. Lovett , Erik M. Gauger

The Feynman integral is one of the most accurate methods for calculating density operator dynamics in open quantum systems. However, the number of time steps that can realistically be used is always limited, therefore one often obtains an…

Computational Physics · Physics 2010-12-14 Nikesh S. Dattani

Simulations of biological macromolecules play an important role in understanding the physical basis of a number of complex processes such as protein folding. Even with increasing computational power and evolution of specialized…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-09-18 Hyungro Lee , Heng Ma , Matteo Turilli , Debsindhu Bhowmik , Shantenu Jha , Arvind Ramanathan

Classical molecular dynamics (MD) simulations are important tools in life and material sciences since they allow studying chemical and biological processes in detail. However, the inherent scalability problem of particle-particle…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-08-14 Michael Schaffner , Luca Benini

Molecular Dynamics - Green's Functions Reaction Dynamics (MD-GFRD) is a multiscale simulation method for particle dynamics or particle-based reaction-diffusion dynamics that is suited for systems involving low particle densities. Particles…

Chemical Physics · Physics 2017-12-06 Luigi Sbailò , Frank Noé

We have previously shown that Good-Turing statistics can be applied to molecular dynamics trajectories to estimate the probability of observing completely new (thus far unobserved) biomolecular structures, and showed that the method is…

Quantitative Methods · Quantitative Biology 2026-01-05 Vasiliki Tsampazi , Nicholas M. Glykos

Quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) simulations have been developed to simulate molecular systems, where an explicit description of changes in the electronic structure is necessary. However, QM/MM MD…

Chemical Physics · Physics 2021-04-15 Lennard Böselt , Moritz Thürlemann , Sereina Riniker

Fourier acceleration has been successfully applied to the simulation of lattice field theories for more than a decade. In this paper, we extend the method to the dynamics of discrete particles moving in continuum. Although our method is…

Statistical Mechanics · Physics 2009-10-31 Francis J. Alexander , Bruce M. Boghosian , Richard C. Brower , S. Roy Kimura

Here, we propose a platform based on ultra-cold fermionic molecules trapped in optical lattices to simulate nonadiabatic effects, as they appear in certain molecular dynamical problems. The idea consists of a judicious choice of two…

Quantum Gases · Physics 2025-09-25 Javier Argüello-Luengo , Alejandro González-Tudela , J. Ignacio Cirac

Kernel methods provide a principled way to perform non linear, nonparametric learning. They rely on solid functional analytic foundations and enjoy optimal statistical properties. However, at least in their basic form, they have limited…

Machine Learning · Statistics 2018-02-01 Alessandro Rudi , Luigi Carratino , Lorenzo Rosasco

Precise prediction of phase diagrams in molecular dynamics (MD) simulations is challenging due to the simultaneous need for long time scales, large length scales and accurate interatomic potentials. We show that thermodynamic integration…

Materials Science · Physics 2023-06-06 Tanooj Shah , Kamron Fazel , Jie Lian , Liping Huang , Yunfeng Shi , Ravishankar Sundararaman

Density Functional Theory calculations traditionally suffer from an inherent cubic scaling with respect to the size of the system, making big calculations extremely expensive. This cubic scaling can be avoided by the use of so-called linear…