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A diverse white matter network and finely tuned neuronal membrane properties allow the brain to transition seamlessly between cognitive states. However, it remains unclear how static structural connections guide the temporal progression of…

The available evidence suggests that dynamic functional connectivity (dFC) can capture time-varying abnormalities in brain activity in resting-state cerebral functional magnetic resonance imaging (rs-fMRI) data and has a natural advantage…

Neurons and Cognition · Quantitative Biology 2023-09-13 Cheng Zhu , Ying Tan , Shuqi Yang , Jiaqing Miao , Jiayi Zhu , Huan Huang , Dezhong Yao , Cheng Luo

The joint analysis of multimodal neuroimaging data is critical in the field of brain research because it reveals complex interactive relationships between neurobiological structures and functions. In this study, we focus on investigating…

Methodology · Statistics 2025-03-25 Tong Lu , Yuan Zhang , Vince Lyzinski , Chuan Bi , Peter Kochunov , Elliot Hong , Shuo Chen

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

The brain is often studied from a network perspective, where functional activity is assessed using functional Magnetic Resonance Imaging (fMRI) to estimate connectivity between predefined neuronal regions. Functional connectivity can be…

Applications · Statistics 2025-07-22 Olivier Bisson , Yanis Aeschlimann , Samuel Deslauriers-Gauthier , Xavier Pennec

Contemporary neuroscience has embraced network science to study the complex and self-organized structure of the human brain; one of the main outstanding issues is that of inferring from measure data, chiefly functional Magnetic Resonance…

Optimization and Control · Mathematics 2017-03-31 Giulia Prando , Mattia Zorzi , Alessandra Bertoldo , Alessandro Chiuso

Functional connectivity is a fundamental property of neural networks that quantifies the segregation and integration of information between cortical areas. Due to mathematical complexity, a theory that could explain how the parameters of…

Neurons and Cognition · Quantitative Biology 2016-05-27 Diego Fasoli , Anna Cattani , Stefano Panzeri

Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set…

Applications · Statistics 2012-02-07 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

Resting-state functional MRI (rs-fMRI) is widely used to noninvasively study human brain networks. Network functional connectivity is often estimated by calculating the timeseries correlation between blood-oxygen-level dependent (BOLD)…

Quantitative Methods · Quantitative Biology 2017-01-25 Nan Xu , R. Nathan Spreng , Peter C. Doerschuk

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

Neurons and Cognition · Quantitative Biology 2013-04-16 Gaël Varoquaux , R. C. Craddock

Predicting cognition from neuroimaging data in healthy individuals offers insights into the neural mechanisms underlying cognitive abilities, with potential applications in precision medicine and early detection of neurological and…

Machine Learning · Computer Science 2025-07-29 Jagruti Patel , Mikkel Schöttner , Thomas A. W. Bolton , Patric Hagmann

Recent advances in neuroimaging along with algorithmic innovations in statistical learning from network data offer a unique pathway to integrate brain structure and function, and thus facilitate revealing some of the brain's organizing…

Signal Processing · Electrical Eng. & Systems 2021-12-21 Yang Li , Gonzalo Mateos , Zhengwu Zhang

Brain age prediction based on neuroimaging data could help characterize both the typical brain development and neuropsychiatric disorders. Pattern recognition models built upon functional connectivity (FC) measures derived from resting…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Hongming Li , Theodore D. Satterthwaite , Yong Fan

A critical question for cognitive neuroscience regards how transitions between cognitive states emerge from the dynamic activity of functional brain networks. However, current methodologies cannot easily evaluate both the spatial and…

Neurons and Cognition · Quantitative Biology 2014-08-25 Gregory Scott , Peter J. Hellyer , Adam Hampshire , Robert Leech

Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ). Traditional approaches might rely solely on SC due to limited functional…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Badhan Mazumder , Ayush Kanyal , Lei Wu , Vince D. Calhoun , Dong Hye Ye

Purpose: Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, where high connectivity among all brain…

Neurons and Cognition · Quantitative Biology 2023-08-28 Anton Orlichenko , Kuan-Jui Su , Qing Tian , Hui Shen , Hong-Wen Deng , Yu-Ping Wang

Synchronization plays a fundamental role in healthy cognitive and motor function. However, how synchronization depends on the interplay between local dynamics, coupling and topology and how prone to synchronization a network with given…

Neurons and Cognition · Quantitative Biology 2018-06-06 David Papo , Javier M. Buldú

This study proposes an approach to estimate the functional localization and connectivity from CBF and BOLD signals simultaneously measured by ASL (arterial spin labeling) MRI, especially using exploratory Structural Equation Modeling…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jiancheng Zhuang

This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined…

Computation · Statistics 2022-07-19 William Consagra , Martin Cole , Zhengwu Zhang

Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…

Neurons and Cognition · Quantitative Biology 2026-04-14 Nicolas Rubido , Venia Batziou , Marwan Fuad , Vesna Vuksanovic
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