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In nature, biological organisms jointly evolve both their morphology and their neurological capabilities to improve their chances for survival. Consequently, task information is encoded in both their brains and their bodies. In robotics,…

Robotics · Computer Science 2020-06-15 Ana Pervan , Todd D. Murphey

Generative molecular design has moved from proof-of-concept to real-world applicability, as marked by the surge in very recent papers reporting experimental validation. Key challenges in explainability and sample efficiency present…

Biomolecules · Quantitative Biology 2024-03-05 Jeff Guo , Philippe Schwaller

Constraint-based optimization of microbial strains and model-based bioprocess design have been used extensively to enhance yields in biotechnological processes. However, strain and process optimization are usually carried out in sequential…

Optimization and Control · Mathematics 2024-07-31 Anita L. Ziegler , Ashutosh Manchanda , Marc-Daniel Stumm , Lars M. Blank , Alexander Mitsos

Stem cells, through their ability to produce daughter stem cells and differentiate into specialized cells, are essential in the growth, maintenance, and repair of biological tissues. Understanding the dynamics of cell populations in the…

Applications · Statistics 2026-02-02 Huyen Nguyen , Haim Bar , Zhiyi Chi , Vladimir Pozdnyakov

Inventory management problems with periodic and controllable resets occur in the context of managing water storage in the developing world and retailing limited-time availability products. In this paper, we consider a set of sequential…

Optimization and Control · Mathematics 2022-09-09 Yoon Lee , Yonatan Mintz , Anil Aswani , Zuo-Jun Max Shen , Cong Yang

Genome wide comparisons between enteric bacteria yield large sets of conserved putative regulatory sites on a gene by gene basis that need to be clustered into regulons. Using the assumption that regulatory sites can be represented as…

Biological Physics · Physics 2009-11-07 Erik van Nimwegen , Mihaela Zavolan , Nikolaus Rajewsky , Eric D. Siggia

Bio-Inspired computing is the subset of Nature-Inspired computing. Job Shop Scheduling Problem is categorized under popular scheduling problems. In this research work, Bacterial Foraging Optimization was hybridized with Ant Colony…

Neural and Evolutionary Computing · Computer Science 2012-11-22 S. Narendhar , T. Amudha

Four lemmas, which constitute the theoretical foundation necessary to determine optimal control strategies for a class of single machine family scheduling problems, are presented in this technical report. The scheduling problem is…

Optimization and Control · Mathematics 2015-02-03 Davide Giglio

One typical use case of large-scale distributed computing in data centers is to decompose a computation job into many independent tasks and run them in parallel on different machines, sometimes known as the "embarrassingly parallel"…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-04-07 Da Wang , Gauri Joshi , Gregory Wornell

How to induce differentiated cells into pluripotent cells has elicited researchers' interests for a long time since pluripotent stem cells are able to offer remarkable potential in numerous subfields of biological research. However, the…

Molecular Networks · Quantitative Biology 2014-12-09 Jiawei Yan , Pu Zheng , Xingjie Pan

Self-assembly processes in biological and synthetic biomolecular systems are often governed by the spatial separation of biochemical processes. While previous work has focused on optimizing self-assembly through fine-tuned reaction…

Biological Physics · Physics 2026-02-17 Severin Angerpointner , Richard Swiderski , Erwin Frey

We present a method for enhanced sampling of molecular dynamics simulations using stochastic resetting. Various phenomena, ranging from crystal nucleation to protein folding, occur on timescales that are unreachable in standard simulations.…

Chemical Physics · Physics 2023-02-09 Ofir Blumer , Shlomi Reuveni , Barak Hirshberg

Deep learning has emerged as a powerful method for extracting valuable information from large volumes of data. However, when new training data arrives continuously (i.e., is not fully available from the beginning), incremental training…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-06 Thomas Bouvier , Bogdan Nicolae , Hugo Chaugier , Alexandru Costan , Ian Foster , Gabriel Antoniu

Approximate Bayesian Computation (ABC) is a widely applicable and popular approach to estimating unknown parameters of mechanistic models. As ABC analyses are computationally expensive, parallelization on high-performance infrastructure is…

Quantitative Methods · Quantitative Biology 2023-05-02 Emad Alamoudi , Felipe Reck , Nils Bundgaard , Frederik Graw , Lutz Brusch , Jan Hasenauer , Yannik Schälte

A major bottleneck of standard auto-regressive large language models is that their inference process is inherently sequential, resulting in very long and costly inference times. To circumvent this, practitioners proposed a class of language…

Machine Learning · Computer Science 2025-11-11 Sitan Chen , Kevin Cong , Jerry Li

Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery that recognizes and corrects specific errors. Here we study…

Populations and Evolution · Quantitative Biology 2026-05-14 Riccardo Ravasio , Kabir Husain , Constantine G. Evans , Rob Phillips , Marco Ribezzi-Crivellari , Jack W. Szostak , Arvind Murugan

In competitive parallel computing, the identical copies of a code in a phase of a sequential program are assigned to processor cores and the result of the fastest core is adopted. In the literature, it is reported that a superlinear speedup…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-22 Naoki Yonezawa

Increasing the batch size during training -- a ''batch ramp'' -- is a promising strategy to accelerate large language model pretraining. While for SGD, doubling the batch size can be equivalent to halving the learning rate, the optimal…

Machine Learning · Computer Science 2025-10-17 Alexandru Meterez , Depen Morwani , Jingfeng Wu , Costin-Andrei Oncescu , Cengiz Pehlevan , Sham Kakade

Replay in neural networks involves training on sequential data with memorized samples, which counteracts forgetting of previous behavior caused by non-stationarity. We present a method where these auxiliary samples are generated on the fly,…

Machine Learning · Computer Science 2020-12-15 Xu Ji , Joao Henriques , Tinne Tuytelaars , Andrea Vedaldi

The variability in cell size of an isogenic population of Escherichia coli has been widely reported in experiment. The probability density function (PDF) of cell lengths has been variously described by exponential and lognormal functions.…

Cell Behavior · Quantitative Biology 2019-05-21 Chaitanya A. Athale