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This dissertation explores applications of discrete geometry in mathematical neuroscience. We begin with convex neural codes, which model the activity of hippocampal place cells and other neurons with convex receptive fields. In Chapter 4,…

Neurons and Cognition · Quantitative Biology 2022-09-19 Caitlin Lienkaemper

This paper proposes a neuronal circuitry layout and synaptic plasticity principles that allow the (pyramidal) neuron to act as a "combinatorial switch". Namely, the neuron learns to be more prone to generate spikes given those combinations…

Biological Physics · Physics 2017-05-09 Marat M. Rvachev

A spiking neuron ``computes'' by transforming a complex dynamical input into a train of action potentials, or spikes. The computation performed by the neuron can be formulated as dimensional reduction, or feature detection, followed by a…

Biological Physics · Physics 2007-05-23 Blaise Aguera y Arcas , Adrienne L. Fairhall , William Bialek

To gain insight into the neural events responsible for visual perception of static and dynamic optical patterns, we study how neural activation spreads in arrays of inhibition-stabilized neural networks with nearest-neighbor coupling. The…

Neurons and Cognition · Quantitative Biology 2016-09-02 Sergey Savel'ev , Sergei Gepshtein

In the mammalian brain, many neuronal ensembles are involved in representing spatial structure of the environment. In particular, there exist cells that encode the animal's location and cells that encode head direction. A number of studies…

Neurons and Cognition · Quantitative Biology 2021-08-10 Y. Dabaghian

Neuroscientists classify neurons into different types that perform similar computations at different locations in the visual field. Traditional methods for neural system identification do not capitalize on this separation of 'what' and…

Machine Learning · Statistics 2018-01-30 David A. Klindt , Alexander S. Ecker , Thomas Euler , Matthias Bethge

Human brain contains about 10 billion neurons, each of which has about 10~10,000 nerve endings from which neurotransmitters are released in response to incoming spikes, and the released neurotransmitters then bind to receptors located in…

Neurons and Cognition · Quantitative Biology 2012-03-06 Xuejuan Zhang , Jianfeng Feng

The interaction between syntax (formal language) and its semantics (meanings of language) is one which has been well studied in categorical logic. The results of this particular study are employed to understand how the brain is able to…

Artificial Intelligence · Computer Science 2021-05-05 Michael Heller

Understanding how high-level concepts are represented within artificial neural networks is a fundamental challenge in the field of artificial intelligence. While existing literature in explainable AI emphasizes the importance of labeling…

Machine Learning · Computer Science 2024-05-17 Abhilekha Dalal , Rushrukh Rayan , Pascal Hitzler

The Neurobiology Of Thinking, Identity, And Geniality Abstract: Mathematically the axioms of representation are subtle, and critical. The CNS expresses its function via its internal neuronal networks in multidimensional, intrinsic frames.…

Neurons and Cognition · Quantitative Biology 2007-05-23 Robert Skopec

Humans and animals exhibit a range of interesting behaviors in dynamic environments, and it is unclear how our brains actively reformat this dense sensory information to enable these behaviors. Experimental neuroscience is undergoing a…

Neurons and Cognition · Quantitative Biology 2023-11-07 Aran Nayebi

A central question for neuroscience is how to characterize brain representations of perceptual and cognitive content. An ideal characterization should distinguish different functional regions with robustness to noise and idiosyncrasies of…

Neurons and Cognition · Quantitative Biology 2024-10-17 Baihan Lin , Nikolaus Kriegeskorte

Animals learn to predict external contingencies from experience through a process of conditioning. A natural mechanism for conditioning is stimulus substitution, whereby the neuronal response to a stimulus with no prior behavioral…

Neurons and Cognition · Quantitative Biology 2024-09-23 Pantelis Vafidis , Antonio Rangel

Neural codes are collections of binary strings motivated by patterns of neural activity. In this paper, we study algorithmic and enumerative aspects of convex neural codes in dimension 1 (i.e. on a line or a circle). We use the theory of…

Combinatorics · Mathematics 2017-02-23 Zvi Rosen , Yan X. Zhang

Mounting evidence in neuroscience suggests the possibility of neuronal representations that individual neurons serve as the substrates of different mental representations in a point-to-point way. Combined with associationism, it can…

Neurons and Cognition · Quantitative Biology 2021-09-06 Chiyin Zheng

Identifying stimulus-driven neural activity patterns is critical for studying the neural basis of cognition. This can be particularly challenging in intracranial datasets, where electrode locations typically vary across patients. This…

Neurons and Cognition · Quantitative Biology 2022-02-07 Jeremy R. Manning

Neurons in the brain are often finely tuned for specific task variables. Moreover, such disentangled representations are highly sought after in machine learning. Here we mathematically prove that simple biological constraints on neurons,…

Neurons and Cognition · Quantitative Biology 2023-04-04 James C. R. Whittington , Will Dorrell , Surya Ganguli , Timothy E. J. Behrens

Understanding neural activity and information representation is crucial for advancing knowledge of brain function and cognition. Neural activity, measured through techniques like electrophysiology and neuroimaging, reflects various aspects…

Neurons and Cognition · Quantitative Biology 2024-07-22 Fengyu Yang , Chao Feng , Daniel Wang , Tianye Wang , Ziyao Zeng , Zhiyang Xu , Hyoungseob Park , Pengliang Ji , Hanbin Zhao , Yuanning Li , Alex Wong

Computation in the brain involves multiple types of neurons, yet the organizing principles for how these neurons work together remain unclear. Information theory has offered explanations for how different types of neurons can optimize the…

Neurons and Cognition · Quantitative Biology 2015-06-22 David B. Kastner , Stephen A. Baccus , Tatyana O. Sharpee

In recent years, several studies have provided insight on the functioning of the brain which consists of neurons and form networks via interconnection among them by synapses. Neural networks are formed by interconnected systems of neurons,…

Neurons and Cognition · Quantitative Biology 2021-01-22 Martin C. Nwadiugwu
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