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Mechanical pain (or mechanical algesia) can both be a vital mechanism warning us for dangers or an undesired medical symptom important to mitigate. Thus, a comprehensive understanding of the different mechanisms of this type of pain is…
Cellular membranes are elastic lipid bilayers that contain a variety of proteins, including ion channels, receptors, and scaffolding proteins. These proteins are known to diffuse in the plane of the membrane and to influence the bending of…
Mechanical cues from the extracellular microenvironment play a central role in regulating the structure, function and fate of living cells. Nevertheless, the precise nature of the mechanisms and processes underlying this crucial cellular…
Hydrated interfaces are ubiquitous in biology and appear on all length scales from ions, individual molecules to membranes and cellular networks. In vivo, they comprise a high degree of self-organization and complex entanglement, which…
Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences.…
We study a stochastic process describing the continuous time evolution of the membrane potentials of finite system of neurons in the absence of external stimuli. The values of the membrane potentials evolve under the effect of {\it chemical…
Tuning cell rearrangements is essential in collective cell movement that underlies cancer progression, wound repair, and embryonic development. A key question is how tissue material properties and morphology emerge from cellular factors…
This paper presents a short selective review of the non-thermal weak microwave field impact on a nerve fiber. The published results of recent experiments are reviewed and analyzed. The theory of the authors is presented, according to which…
The saltatory propagation of action potentials on myelinated axons is conventionally explained by the mechanism employing local circuit ionic current flows between nodes of Ranvier. Under this framework, the myelin sheath with up to 100…
The viscosity of fluids is generally understood in terms of kinetic mechanisms, i.e., particle collisions, or thermodynamic ones as imposed through structural distortions upon e.g. applying shear. Often the former is less relevant, and…
An elastic membrane with embedded nematic molecules is considered as a model of anisotropic fluid membrane with internal ordering. By considering the geometric coupling between director field and membrane curvature, the nematic texture is…
In the last fifteen years a debate emerged about the validity of the famous Hodgkin-Huxley model for nerve impulse. Mechanical models have been proposed. This note reviews the experimental properties of the nerve impulse and discusses the…
We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane…
Cortical network functioning critically depends on finely tuned interactions to afford neuronal activity propagation over long distances while avoiding runaway excitation. This importance is highlighted by the pathological consequences and…
We investigate the effect of an applied electric potential on the mechanics of a coarse grained POPC bilayer under tension. The size and duration of our simulations allow for a detailed and accurate study of the fluctuations. Effects on the…
The response of the living tissue to the effects of strong heating or cooling can cause the blood flow rate to vary by an order of magnitude. A mathematical model for the freezing of living tissue is formulated which takes into account the…
In this paper, attention is drawn to the importance of accounting for osmotic pressure when analyzing physiological effects on cellular structures in plasma medicine. Interaction of a weakly ionized plasma jet with a saline solution leads…
Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that…
We give an explicit formula for the membrane potential of cells in terms of the intracellular and extracellular ionic concentrations, and derive equations for the ionic currents that flow through channels, exchangers and electrogenic pumps.…
Cell membranes interact with a myriad of curvature-active proteins that control membrane morphology and are responsible for mechanosensation and mechanotransduction. Some of these proteins, such as those containing BAR domains, are curved…