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Reconstructing a synaptic wiring diagram, or connectome, from electron microscopy (EM) images of brain tissue currently requires many hours of manual annotation or proofreading (Kasthuri and Lichtman, 2010; Lichtman and Sanes, 2008; Seung,…

Medical images used in clinical practice are heterogeneous and not the same quality as scans studied in academic research. Preprocessing breaks down in extreme cases when anatomy, artifacts, or imaging parameters are unusual or protocols…

Image and Video Processing · Electrical Eng. & Systems 2022-08-31 Mostafa Mehdipour Ghazi , Mads Nielsen

In computer vision, image segmentation is always selected as a major research topic by researchers. Due to its vital rule in image processing, there always arises the need of a better image segmentation method. Clustering is an unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2015-06-08 Dibya Jyoti Bora , Anil Kumar Gupta

Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction is extensively used to reveal structural information of macromolecular complexes. Aiming at the highest achievable resolution, state of the art electron…

Computer Vision and Pattern Recognition · Computer Science 2020-05-04 Ramin Norousi , Stephan Wickles , Thomas Becker , Roland Beckmann , Volker J. Schmid , Achim Tresch

We present {\mu}Split, a dedicated approach for trained image decomposition in the context of fluorescence microscopy images. We find that best results using regular deep architectures are achieved when large image patches are used during…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Ashesh , Alexander Krull , Moises Di Sante , Francesco Silvio Pasqualini , Florian Jug

Semantic segmentation of microscopic cell images using deep learning is an important technique, however, it requires a large number of images and ground truth labels for training. To address the above problem, we consider an efficient…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Sota Kato , Kazuhiro Hotta

Electron microscopy (EM) enables the reconstruction of neural circuits at the level of individual synapses, which has been transformative for scientific discoveries. However, due to the complex morphology, an accurate reconstruction of…

To date, most discoveries of network subcomponents that implement human-interpretable computations in deep vision models have involved close study of single units and large amounts of human labor. We explore scalable methods for extracting…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Achyuta Rajaram , Neil Chowdhury , Antonio Torralba , Jacob Andreas , Sarah Schwettmann

Morphology of mitochondria plays critical roles in mediating their physiological functions. Accurate segmentation of mitochondria from 3D electron microscopy (EM) images is essential to quantitative characterization of their morphology at…

Computer Vision and Pattern Recognition · Computer Science 2022-06-16 Yunpeng Xiao , Youpeng Zhao , Ge Yang

Image segmentation from referring expressions is a joint vision and language modeling task, where the input is an image and a textual expression describing a particular region in the image; and the goal is to localize and segment the…

Computer Vision and Pattern Recognition · Computer Science 2016-08-31 Ronghang Hu , Marcus Rohrbach , Subhashini Venugopalan , Trevor Darrell

A wide range of techniques can be considered for segmentation of images of nanostructured surfaces. Manually segmenting these images is time-consuming and results in a user-dependent segmentation bias, while there is currently no consensus…

Image and Video Processing · Electrical Eng. & Systems 2020-08-31 Steff Farley , Jo E. A. Hodgkinson , Oliver M. Gordon , Joanna Turner , Andrea Soltoggio , Philip J. Moriarty , Eugenie Hunsicker

The success of large language models has inspired the computer vision community to explore image segmentation foundation model that is able to zero/few-shot generalize through prompt engineering. Segment-Anything(SAM), among others, is the…

Computer Vision and Pattern Recognition · Computer Science 2024-04-11 Haojie Zhang , Yongyi Su , Xun Xu , Kui Jia

Semantic image segmentation is one of the most important tasks in medical image analysis. Most state-of-the-art deep learning methods require a large number of accurately annotated examples for model training. However, accurate annotation…

Computer Vision and Pattern Recognition · Computer Science 2020-04-21 Ning Zhang , Susan Francis , Rayaz Malik , Xin Chen

Scanning Electron Microscopy (SEM) is indispensable in modern materials science, enabling high-resolution imaging across a wide range of structural, chemical, and functional investigations. However, SEM imaging remains constrained by…

Etruscan mirrors constitute a significant category in Etruscan art, characterized by elaborate figurative illustrations featured on their backside. A laborious and costly aspect of their analysis and documentation is the task of manually…

Computer Vision and Pattern Recognition · Computer Science 2024-12-11 Rafael Sterzinger , Christian Stippel , Robert Sablatnig

This paper introduces an efficient and robust method for discovering interpretable circuits in large language models using discrete sparse autoencoders. Our approach addresses key limitations of existing techniques, namely computational…

Computation and Language · Computer Science 2024-05-22 Charles O'Neill , Thang Bui

The path to interpreting a language model often proceeds via analysis of circuits -- sparse computational subgraphs of the model that capture specific aspects of its behavior. Recent work has automated the task of discovering circuits. Yet,…

Computation and Language · Computer Science 2025-04-03 Adithya Bhaskar , Alexander Wettig , Dan Friedman , Danqi Chen

Segmentation of microscopy images constitutes an ill-posed inverse problem due to measurement noise, weak object boundaries, and limited labeled data. Although deep neural networks provide flexible nonparametric estimators, unconstrained…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Seema K. Poudel , Sunny K. Khadka

Accurate segmentation of neural structures in Electron Microscopy (EM) images is paramount for neuroscience. However, this task is challenged by intricate morphologies, low signal-to-noise ratios, and scarce annotations, limiting the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Zhenghua Li , Hang Chen , Zihao Sun , Kai Li , Xiaolin Hu

Extracting a block of interest referred to as segmenting a specified block in an image and studying its characteristics is of general research interest, and could be a challenging if such a segmentation task has to be carried out directly…

Computer Vision and Pattern Recognition · Computer Science 2014-02-19 Mohammed Javed , P. Nagabhushan , B. B. Chaudhuri