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Pairwise Euclidean distance calculation is a fundamental step in many machine learning and data analysis algorithms. In real-world applications, however, these distances are frequently distorted by heteroskedastic noise$\unicode{x2014}$a…

Machine Learning · Statistics 2025-09-12 Keyi Li , Yuval Kluger , Boris Landa

Generative models are invaluable in many fields of science because of their ability to capture high-dimensional and complicated distributions, such as photo-realistic images, protein structures, and connectomes. How do we evaluate the…

To gain insight into the mechanisms behind machine learning methods, it is crucial to establish connections among the features describing data points. However, these correlations often exhibit a high-dimensional and strongly nonlinear…

Machine Learning · Computer Science 2025-03-04 Lorenzo Basile , Santiago Acevedo , Luca Bortolussi , Fabio Anselmi , Alex Rodriguez

We introduce and study methods for inferring and learning from correspondences among neurons. The approach enables alignment of data from distinct multiunit studies of nervous systems. We show that the methods for inferring correspondences…

Neurons and Cognition · Quantitative Biology 2015-01-28 Ashish Kapoor , E. Paxon Frady , Stefanie Jegelka , William B. Kristan , Eric Horvitz

Motivated by novel results in the theory of correlated sequences, we analyze the dynamics of random walks with long-term memory (binary chains with long-range correlations). In our model, the probability for a unit bit in a binary string…

Statistical Mechanics · Physics 2009-11-10 Shahar Hod , Uri Keshet

We exhibit a one to one correspondence between some universal probabilistic properties of the ordering coordinate of one-dimensional Ising-like models and a class of continuous time random walks. This correspondence provides an new…

Statistical Mechanics · Physics 2007-05-23 Michel Droz , Max-Olivier Hongler

Statistical models that analyse (pairwise) relations between variables encompass assumptions about the underlying mechanism that generated the associations in the observed data. In the present paper we demonstrate that three Ising model…

Methodology · Statistics 2016-10-07 Joost Kruis , Gunter Maris

Charge correlations in dense ionic fluids give rise to novel effects such as long-range screening and colloidal stabilization which are not predicted by the classic Debye-Huckel theory. We show that a Coulomb or charge-frustrated Ising…

Soft Condensed Matter · Physics 2018-11-01 Nicholas B. Ludwig , Kinjal Dasbiswas , Dmitri V. Talapin , Suriyanarayanan Vaikuntanathan

DNA sequence alignment is important today as it is usually the first step in finding gene mutation, evolutionary similarities, protein structure, drug development and cancer treatment. Covid-19 is one recent example. There are many…

Genomics · Quantitative Biology 2023-06-01 Suchindra , Preetam Nagaraj

Supervised deep learning models require significant amount of labeled data to achieve an acceptable performance on a specific task. However, when tested on unseen data, the models may not perform well. Therefore, the models need to be…

Computer Vision and Pattern Recognition · Computer Science 2024-01-01 Akshit Achara , Ram Krishna Pandey

The zero-temperature transmission rate spectrum of a double-chain tight-binding model for real DNA is calculated. It is shown that a band of extended-like states exists only for finite chain length with strong inter-chain coupling. While…

Disordered Systems and Neural Networks · Physics 2009-11-11 Gang Xiong , X. R. Wang

The Lie point symmetries of a coupled system of two nonlinear differential-difference equations are investigated. It is shown that in special cases the symmetry group can be infinite dimensional, in other cases up to 10 dimensional. The…

solv-int · Physics 2009-10-31 D. Gomez-Ullate , S. Lafortune , P. Winternitz

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known…

Genomics · Quantitative Biology 2025-09-10 Haley Stone , Jing Du , Hao Xue , Matthew Scotch , David Heslop , Andreas Züfle , Chandini Raina MacIntyre , Flora Salim

The melting behavior of long, heterogeneous DNA chains is examined within the framework of the nonlinear lattice dynamics based Peyrard-Bishop-Dauxois (PBD) model. Data for the pBR322 plasmid and the complete T7 phage have been used to…

Biological Physics · Physics 2012-02-20 Nikos Theodorakopoulos

We propose a new distance metric for DNA sequences, which can be defined on any evolutionary Markov model with infinitesimal generator matrix Q. That is the new metric can be defined under existing models such as Jukes-Cantor model,…

Populations and Evolution · Quantitative Biology 2009-02-12 Viswanath. C. Narayanan

The short distance asymptotics of the Ising Model scaling functions are computed for the scaling functions that arise as continuum limits of lattice correlations from below the critical temperature.

Exactly Solvable and Integrable Systems · Physics 2015-06-26 John Palmer

We propose to describe correlations in classical and quantum systems in terms of full counting statistics of a suitably chosen discrete observable. The method is illustrated with two exactly solvable examples: the classical one-dimensional…

Strongly Correlated Electrons · Physics 2013-04-16 Dmitri A. Ivanov , Alexander G. Abanov

We study the statistical properties of Ising spin chains with finite (although arbitrary large) range of interaction between the elements. We examine mesoscopic subsystems (fragments of an Ising chain) with the lengths comparable with the…

Statistical Mechanics · Physics 2009-11-13 S. S. Apostolov , Z. A. Mayzelis , O. V. Usatenko , V. A. Yampol'skii

We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignments of sequences without mutual correlations are found to…

Biological Physics · Physics 2009-09-25 Dirk Drasdo , Terence Hwa , Michael Lassig

Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multi-protein complexes, and to enable signal transduction in various pathways. Functional interactions between proteins result in…

Biological Physics · Physics 2016-11-21 Anne-Florence Bitbol , Robert S. Dwyer , Lucy J. Colwell , Ned S. Wingreen
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