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RNA function is tied to secondary structure, operating through dynamic and heterogeneous structural ensembles. While current analysis tools typically output single static structures or averaged contact maps, chemical probing methods like…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Jianhui Li , Redmond P. Smyth , Guido Sanguinetti , Giovanni Bussi

Molecular dynamics (MD) simulations enable the study of the motion of small and large (bio)molecules and the estimation of their conformational ensembles. The description of the environment (solvent) has thereby a large impact. Implicit…

Chemical Physics · Physics 2023-05-25 Paul Katzberger , Sereina Riniker

Context: We integrate the 2D MHD ideal equations of a straight slab to simulate observational results associated with fundamental sausage trapped modes. Aims: Starting from a non-equilibrium state with a dense chromospheric layer, we…

Solar and Stellar Astrophysics · Physics 2011-01-21 M. Cécere , A. Costa , O. Reula

Recently several minimum free energy (MFE) folding algorithms for predicting the joint structure of two interacting RNA molecules have been proposed. Their folding targets are interaction structures, that can be represented as diagrams with…

Combinatorics · Mathematics 2010-06-22 Thomas J. X. Li , Christian M. Reidys

Secondary structure plays an important role in determining the function of non-coding RNAs. Hence, identifying RNA secondary structures is of great value to research. Computational prediction is a mainstream approach for predicting RNA…

Biomolecules · Quantitative Biology 2021-09-15 Qi Zhao , Zheng Zhao , Xiaoya Fan , Zhengwei Yuan , Qian Mao , Yudong Yao

In an effort to develop a rapid, reliable, and cost-effective method for predicting the structure of single-phase high entropy alloys, a Graph Neural Network (ALIGNN-FF) based approach was introduced. This method was successfully tested on…

Hydrogen bond patterns, proton ordering, and phase transitions of monolayer ice in two-dimensional hydrophobic confinement are fundamentally different from those found for bulk ice. To investigate the behavior of quasi-2D ice, we perform…

Chemical Physics · Physics 2019-01-15 Shujuan Li , Burkhard Schmidt

Predicting material properties of 3D printed polymer products is a challenge in additive manufacturing due to the highly localized and complex manufacturing process. The microstructure of such products is fundamentally different from the…

Soft Condensed Matter · Physics 2023-11-01 Caglar Tamur , Shaofan Li , Danielle Zeng

We present large-scale molecular dynamics (MD) simulations based on a machine-learning interatomic potential to investigate the wet etching behavior of various GaN facets in alkaline solution-a process critical to the fabrication of…

Materials Science · Physics 2025-05-14 Purun-hanul Kim , Jeong Min Choi , Seungwu Han , Youngho Kang

Based on detailed 2D and 3D numerical radiation-hydrodynamics (RHD) simulations of time-dependent compressible convection, we have studied the dynamics and thermal structure of the convective surface layers of a prototypical late-type…

Astrophysics · Physics 2009-11-07 H. -G. Ludwig , F. Allard , P. H. Hauschildt

We propose GrainGNN, a surrogate model for the evolution of polycrystalline grain structure under rapid solidification conditions in metal additive manufacturing. High fidelity simulations of solidification microstructures are typically…

Computational Engineering, Finance, and Science · Computer Science 2024-02-02 Yigong Qin , Stephen DeWitt , Balasubramaniam Radhakrishnan , George Biros

The accurate prediction of protein-RNA binding affinity remains an unsolved problem in structural biology, limiting opportunities in understanding gene regulation and designing RNA-targeting therapeutics. A central obstacle is the…

The topology of nanoporous metals is crucial for determining their mechanical response. In this work, we generated 6,000 gold and 422 silver nanoporous structures and calculated three components of elastic modulus with Molecular Dynamics…

Simulations of turbulent fluid flow around long cylindrical structures are computationally expensive because of the vast range of length scales, requiring simplifications such as dimensional reduction. Current dimensionality reduction…

Fluid Dynamics · Physics 2021-02-25 Bernat Font , Gabriel D. Weymouth , Vinh-Tan Nguyen , Owen R. Tutty

There is strong observational evidence that the convective cores of intermediate-mass and massive main sequence stars are substantially larger than those predicted by standard stellar-evolution models. However, it is unclear what physical…

Solar and Stellar Astrophysics · Physics 2024-08-20 R. Andrassy , G. Leidi , J. Higl , P. V. F. Edelmann , F. R. N. Schneider , F. K. Roepke

The objective of this work is to study the applicability of various Machine Learning algorithms for prediction of some rock properties which geoscientists usually define due to special lab analysis. We demonstrate that these special…

Machine Learning · Computer Science 2019-02-19 Andrei Erofeev , Denis Orlov , Alexey Ryzhov , Dmitry Koroteev

The evolutionary trajectory of a protein through sequence space is constrained by function and three-dimensional (3D) structure. Residues in spatial proximity tend to co-evolve, yet attempts to invert the evolutionary record to identify…

Biomolecules · Quantitative Biology 2015-03-13 Debora S. Marks , Lucy J. Colwell , Robert Sheridan , Thomas A. Hopf , Andrea Pagnani , Riccardo Zecchina , Chris Sander

Large-scale storage technologies are crucial to balance consumption and intermittent production of renewable energy systems. One of these technologies can be developed by converting the excess energy into compressed air or hydrogen, i.e.,…

Geophysics · Physics 2024-07-29 Hermínio Tasinafo Honório , Hadi Hajibeygi

Non-ideal MHD effects are thought to be a crucial component of the star-formation process. Numerically, several complications render the study of non-ideal MHD effects in 3D simulations extremely challenging and hinder our efforts of…

Astrophysics of Galaxies · Physics 2025-02-12 E. Agianoglou , A. Tritsis , K. Tassis

Enhanced dynamical fluctuations of RNAs, facilitated by a network of water molecules with strong interactions with RNA, are suspected to be critical in their ability to respond to a variety of cellular signals. Using atomically detailed…

Biomolecules · Quantitative Biology 2015-01-15 Jeseong Yoon , Jong-Chin Lin , Changbong Hyeon , D. Thirumalai
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