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One of the primary goals of systems neuroscience is to relate the structure of neural circuits to their function, yet patterns of connectivity are difficult to establish when recording from large populations in behaving organisms. Many…

Machine Learning · Computer Science 2020-12-08 Anne Draelos , Eva A. Naumann , John M. Pearson

A shape filter is presented to repair segmentation results obtained in calcium imaging of neurons in vivo. This post-segmentation algorithm can automatically smooth the shapes obtained from a preliminary segmentation, while precluding the…

Image and Video Processing · Electrical Eng. & Systems 2018-06-04 Jie Wang , Zhongxiao Fu , Nasrin Sadeghzadehyazdi , Jonathan Kipnis , Scott T. Acton

Computational Cannula Microscopy (CCM) is a high-resolution widefield fluorescence imaging approach deep inside tissue, which is minimally invasive. Rather than using conventional lenses, a surgical cannula acts as a lightpipe for both…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Ruipeng Guo , Zhimeng Pan , Andrew Taibi , Jason Shepherd , Rajesh Menon

Optical computing has been recently proposed as a new compute paradigm to meet the demands of future AI/ML workloads in datacenters and supercomputers. However, proposed implementations so far suffer from lack of scalability, large…

Hardware Architecture · Computer Science 2022-10-21 Daniel Sturm , Sajjad Moazeni

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

With the growing demand for interpretable deep learning models, this paper introduces Integrative CAM, an advanced Class Activation Mapping (CAM) technique aimed at providing a holistic view of feature importance across Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Aniket K. Singh , Debasis Chaudhuri , Manish P. Singh , Samiran Chattopadhyay

Comprehensive, synapse-resolution imaging of the brain will be crucial for understanding neuronal computations and function. In connectomics, this has been the sole purview of volume electron microscopy (EM), which entails an excruciatingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Yicong Li , Yaron Meirovitch , Aaron T. Kuan , Jasper S. Phelps , Alexandra Pacureanu , Wei-Chung Allen Lee , Nir Shavit , Lu Mi

The ability to efficiently infer system parameters is essential in any signal-processing task that requires fast operation. Dealing with quantum systems, a serious challenge arises due to substantial growth of the underlying Hilbert space…

Quantum Physics · Physics 2025-04-23 Lewis A. Clark , Jan Kolodynski

The necessity of abundant annotated data and complex network architectures presents a significant challenge in deep-learning Salient Object Detection (deep SOD) and across the broader deep-learning landscape. This challenge is particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Felipe Crispim Salvagnini , Jancarlo F. Gomes , Cid A. N. Santos , Silvio Jamil F. Guimarães , Alexandre X. Falcão

To explain individual differences in development, behavior, and cognition, most previous studies focused on projecting resting-state functional MRI (fMRI) based functional connectivity (FC) data into a low-dimensional space via linear…

Neurons and Cognition · Quantitative Biology 2018-11-01 Li Xiao , Julia M. Stephen , Tony W. Wilson , Vince D. Calhoun , Yu-Ping Wang

The Computer_Aided Diagnosis (CAD) systems facilitate accurate diagnosis of diseases. The development of CADs by leveraging third generation neural network, namely, Spiking Neural Network (SNN), is essential to utilize of the benefits of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-28 Mohaddeseh Chegini , Ali Mahloojifar

We advocate for a new paradigm of cosmological likelihood-based inference, leveraging recent developments in machine learning and its underlying technology, to accelerate Bayesian inference in high-dimensional settings. Specifically, we…

Cosmology and Nongalactic Astrophysics · Physics 2024-09-06 Davide Piras , Alicja Polanska , Alessio Spurio Mancini , Matthew A. Price , Jason D. McEwen

Despite coronary artery calcium scoring being considered a largely solved problem within the realm of medical artificial intelligence, this paper argues that significant improvements can still be made. By shifting the focus from pathology…

Background: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Xiaohui Zhang , Eric C. Landsness , Hanyang Miao , Wei Chen , Michelle Tang , Lindsey M. Brier , Joseph P. Culver , Jin-Moo Lee , Mark A. Anastasio

State-space models (SSM) with Markov switching offer a powerful framework for detecting multiple regimes in time series, analyzing mutual dependence and dynamics within regimes, and asserting transitions between regimes. These models…

Methodology · Statistics 2021-06-14 David Degras , Chee-Ming Ting , Hernando Ombao

Scene parsing is a great challenge for real-time semantic segmentation. Although traditional semantic segmentation networks have made remarkable leap-forwards in semantic accuracy, the performance of inference speed is unsatisfactory.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Zhengbin Zhang , Zhenhao Xu , Xingsheng Gu , Juan Xiong

CAM-based methods are widely-used post-hoc interpretability method that produce a saliency map to explain the decision of an image classification model. The saliency map highlights the important areas of the image relevant to the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Magamed Taimeskhanov , Ronan Sicre , Damien Garreau

The crossed random effects model is widely used, finding applications in various fields such as longitudinal studies, e-commerce, and recommender systems, among others. However, these models encounter scalability challenges, as the…

Methodology · Statistics 2025-10-21 Disha Ghandwani , Swarnadip Ghosh , Trevor Hastie , Art B. Owen

We propose a novel sampling framework for inference in probabilistic models: an active learning approach that converges more quickly (in wall-clock time) than Markov chain Monte Carlo (MCMC) benchmarks. The central challenge in…

Machine Learning · Statistics 2014-11-04 Tom Gunter , Michael A. Osborne , Roman Garnett , Philipp Hennig , Stephen J. Roberts

Inference of brain functional connectivity networks from resting-state fMRI data is a key focus in neuroimaging. This paper introduces new Bayesian approaches for inferring a functional connectivity graph from multivariate resting-state…

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