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Even as machine learning exceeds human-level performance on many applications, the generality, robustness, and rapidity of the brain's learning capabilities remain unmatched. How cognition arises from neural activity is a central open…

Neural and Evolutionary Computing · Computer Science 2023-10-17 Max Dabagia , Christos H. Papadimitriou , Santosh S. Vempala

Cells often perform computations in response to environmental cues. A simple example is the classic problem, first considered by Berg and Purcell, of determining the concentration of a chemical ligand in the surrounding media. On general…

Molecular Networks · Quantitative Biology 2015-06-04 Pankaj Mehta , David J. Schwab

There are a plethora of applications that demand high throughput and low latency algorithms leveraging machine learning methods. This need for real time processing can be seen in industries ranging from developing neural network based…

Machine Learning · Computer Science 2020-04-14 Yash Akhauri

Voltage-gated ion channels are essential for propagating signals in neurons. Each channel senses the local membrane potential created by nearby ions. Fluctuations in these ions introduce two fundamental noise sources: (i) shot noise, from…

Biological Physics · Physics 2026-04-07 Jose M. Betancourt , Benjamin B. Machta

Does the energy requirements for the human brain give energy constraints that give reason to doubt the feasibility of artificial intelligence? This report will review some relevant estimates of brain bioenergetics and analyze some of the…

Artificial Intelligence · Computer Science 2016-02-15 Anders Sandberg

Noise is an inherent part of neuronal dynamics, and thus of the brain. It can be observed in neuronal activity at different spatiotemporal scales, including in neuronal membrane potentials, local field potentials, electroencephalography,…

Neurons and Cognition · Quantitative Biology 2019-01-03 Daqing Guo , Matjaz Perc , Tiejun Liu , Dezhong Yao

Motivated by applications in blockchains and sensor networks, we consider a model of $n$ nodes trying to reach consensus on their majority bit. Each node $i$ is assigned a bit at time zero, and is a finite automaton with $m$ bits of memory…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-06-08 Giulia Fanti , Nina Holden , Yuval Peres , Gireeja Ranade

Patterns of microcircuitry suggest that the brain has an array of repeated canonical computational units. Yet neural representations are distributed, so the relevant computations may only be related indirectly to single-neuron…

Neurons and Cognition · Quantitative Biology 2023-10-17 Rajkumar Vasudeva Raju , Zhe Li , Scott Linderman , Xaq Pitkow

In systems neuroscience, most models posit that brain regions communicate information under constraints of efficiency. Yet, evidence for efficient communication in structural brain networks characterized by hierarchical organization and…

Experiments suggest that cerebral cortex gains several functional advantages by operating in a dynamical regime near the critical point of a phase transition. However, a long-standing criticism of this hypothesis is that critical dynamics…

Neurons and Cognition · Quantitative Biology 2020-09-30 Kathleen Finlinson , Woodrow L. Shew , Daniel B. Larremore , Juan G. Restrepo

This paper introduces channel gating, a dynamic, fine-grained, and hardware-efficient pruning scheme to reduce the computation cost for convolutional neural networks (CNNs). Channel gating identifies regions in the features that contribute…

Machine Learning · Computer Science 2019-10-30 Weizhe Hua , Yuan Zhou , Christopher De Sa , Zhiru Zhang , G. Edward Suh

We introduce combinatorial interpretability, a methodology for understanding neural computation by analyzing the combinatorial structures in the sign-based categorization of a network's weights and biases. We demonstrate its power through…

Machine Learning · Computer Science 2025-05-07 Micah Adler , Dan Alistarh , Nir Shavit

Cortical sensory neurons are known to be highly variable, in the sense that responses evoked by identical stimuli often change dramatically from trial to trial. The origin of this variability is uncertain, but it is usually interpreted as…

Neurons and Cognition · Quantitative Biology 2007-05-23 Gleb Basalyga , Emilio Salinas

Spiking Neural Networks (SNNs) offer energy-efficient and biologically plausible alternatives to traditional artificial neural networks, but their performance depends critically on the tuning of neuron model parameters. In this work, we…

Neural and Evolutionary Computing · Computer Science 2025-07-22 Szymon Mazurek , Jakub Caputa , Maciej Wielgosz

Brain simulation, as one of the latest advances in artificial intelligence, facilitates better understanding about how information is represented and processed in the brain. The extreme complexity of human brain makes brain simulations only…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-17 Xin Du

This work explores a distributed computing setting where $K$ nodes are assigned fractions (subtasks) of a computational task in order to perform the computation in parallel. In this setting, a well-known main bottleneck has been the…

Information Theory · Computer Science 2018-02-13 Emanuele Parrinello , Eleftherios Lampiris , Petros Elia

In this paper, we investigate computational power of threshold circuits and other theoretical models of neural networks in terms of the following four complexity measures: size (the number of gates), depth, weight and energy. Here the…

Computational Complexity · Computer Science 2023-06-29 Kei Uchizawa , Haruki Abe

Networks of superconducting optoelectronic neurons are investigated for their near-term technological potential and long-term physical limitations. Networks with short average path length, high clustering coefficient, and power-law degree…

Neural and Evolutionary Computing · Computer Science 2018-05-17 Jeffrey M. Shainline , Jeff Chiles , Sonia M. Buckley , Adam N. McCaughan , Richard P. Mirin , Sae Woo Nam

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this…

Neurons and Cognition · Quantitative Biology 2008-11-14 Yong Chen , Lianchun Yu , Shao-Meng Qin

For reliable transmission across a noisy communication channel, classical results from information theory show that it is asymptotically optimal to separate out the source and channel coding processes. However, this decomposition can fall…

Machine Learning · Computer Science 2019-05-15 Kristy Choi , Kedar Tatwawadi , Aditya Grover , Tsachy Weissman , Stefano Ermon