Related papers: Survival Probabilities at Spherical Frontiers
If deleterious mutations near a fitness maximum in a spatially distributed population are sufficiently frequent or detrimental, the population can undergo a fitness collapse, similarly to the Muller's ratchet effect in well-mixed…
The evolution of a surface excitation in a two dimentional model is analyzed. I) It starts quadratically up to a spreading time t_{S}. II) It follows an exponential behavior governed by a self-consistent Fermi Golden Rule. III) At longer…
The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous…
In this paper, we study a nonlinear free boundary problem modeling the growth of spherically symmetric tumors. The tumor consists of a central necrotic core, an intermediate annual quiescent-cell layer, and an outer proliferating-cell…
The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation…
The temporal modal and nonmodal growth of three-dimensional perturbations in the boundary-layer flow over an infinite compliant flat wall is considered. Using a wall-normal velocity/wall-normal vorticity formalism, the dynamic boundary…
In this paper, we analyse a model for the growth of three-dimensional walled cells. In this model the biomechanical expansion of the cell is coupled with the geometry of its wall. We consider that the density of building material depends on…
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations co-segregate. We perform individual-based simulations of a uniform linear habitat and complement them with…
In this kind of model, the main characteristic that determines population viability in the long term is the stochastic growth rate (SGR) denoted $\lambda_S$. When $\lambda_S$ is larger than one, the population grows exponentially with…
A one-dimensional cellular automaton with a probabilistic evolution rule can generate stochastic surface growth in $(1 + 1)$ dimensions. Two such discrete models of surface growth are constructed from a probabilistic cellular automaton…
Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…
In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…
Inspired by Fisher's geometric approach to study beneficial mutations, we analyse probabilities of beneficial mutation and crossover recombination of strings in a general Hamming space with arbitrary finite alphabet. Mutations and…
Spatially extended population dynamics models that incorporate intrinsic noise serve as case studies for the role of fluctuations and correlations in biological systems. Including spatial structure and stochastic noise in predator-prey…
The interplay between space and evolution is an important issue in population dynamics, that is in particular crucial in the emergence of polymorphism and spatial patterns. Recently, biological studies suggest that invasion and evolution…
We study the asymptotic shape of the occupied region for monotone deterministic dynamics in d-dimensional Euclidean space parametrized by a threshold theta, and a Borel set N with positive and finite Lebesgue measure. If A_n denotes the…
We consider a model of interface growth in two dimensions, given by a height function on the sites of the one--dimensional integer lattice. According to the discrete time update rule, the height above the site $x$ increases to the height…
We consider a spatial model of cancer in which cells are points on the $d$-dimensional torus $\mathcal{T}=[0,L]^d$, and each cell with $k-1$ mutations acquires a $k$th mutation at rate $\mu_k$. We will assume that the mutation rates $\mu_k$…
We consider a spatial (line) model for invasion of a population by a single mutant with a stochastically selectively neutral fitness landscape, independent from the fitness landscape for non-mutants. This model is similar to those…
The asymptotic shape of randomly growing radial clusters is studied. We pose the problem in terms of the dynamics of stochastic partial differential equations. We concentrate on the properties of the realizations of the stochastic growth…