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A scaling analysis is presented of the statistics of long DNA confined in nanochannels and nanoslits. It is argued that there are several regimes in between the de Gennes and Odijk limits introduced long ago. The DNA chain folds back on…

Soft Condensed Matter · Physics 2009-11-13 T. Odijk

Nonreversible Markov chains can outperform reversible chains in the Markov chain Monte Carlo method. Lifting is a versatile approach to introducing net stochastic flow in state space and constructing a nonreversible Markov chain. We present…

Statistical Mechanics · Physics 2022-11-11 Hidemaro Suwa

We study the statistics of branching polymers with excluded-volume interactions, by modeling them as single self-avoiding trees on a generic regular periodic lattice with coordination number $q$. Each lattice site can be occupied at most by…

Statistical Mechanics · Physics 2025-10-13 Davide Marcato , Achille Giacometti , Amos Maritan , Angelo Rosa

For the $t$-$J$ model, variational wave functions can generally be constructed based on an accurate description of antiferromagnetism (AFM) at half-filling and an exact phase-string sign structure under doping. The single-hole-doped and…

Strongly Correlated Electrons · Physics 2026-02-25 Can Cui , Jing-Yu Zhao , Zheng-Yu Weng

We show the existence of a high interrelation between the different loops that may appear in a DNA segment. Conformational changes in a chain segment caused by the formation of a particular loop may either promote or prevent the appearance…

Biomolecules · Quantitative Biology 2009-03-24 Artur Garcia-Saez , J. Miguel Rubi

A lattice model of the directed self-avoiding walk is used to estimate the possibility on the formation of an infinitely long linear semi-flexible copolymer chain. The copolymer chain is assumed to composed of four different types of the…

Statistical Mechanics · Physics 2021-04-28 Pramod Kumar Mishra

Single-molecule experiments in which force is applied to DNA or RNA molecules have enabled important discoveries of nucleic acid properties and nucleic acid-enzyme interactions. These experiments rely on a model of the polymer…

Biological Physics · Physics 2011-11-09 Jinyu Li , Philip C. Nelson , M. D. Betterton

We consider an one-dimensional conservation law with random space-time forcing and calculate using large deviations the exponentially small probabilities of anomalous shock profile displacements. Under suitable hypotheses on the spatial…

Probability · Mathematics 2012-06-08 Josselin Garnier , George Papanicolaou , Tzu-Wei Yang

Chromosomes are crumpled polymer chains further folded into a sequence of stochastic loops via loop extrusion. While extrusion has been verified experimentally, the particular means by which the extruding complexes bind DNA polymer remains…

Soft Condensed Matter · Physics 2023-06-14 Kirill Polovnikov , Bogdan Slavov

Single molecule magnets (SMMs) with single-ion anisotropies $\mathbf d$, comparable to exchange interactions J, between spins have recently been synthesized. In this paper, we provide theoretical insights into the magnetism of such systems.…

Strongly Correlated Electrons · Physics 2017-11-22 Sumit Haldar , Rajamani Raghunathan , Jean-Pascal Sutter , S. Ramasesha

Based on three general guiding principles, i.e., no double occupancy constraint, accurate description of antiferromagnetism at half-filling, and the precise sign structure of the $t$-$J$ model, a new ground state wave function has been…

Strongly Correlated Electrons · Physics 2015-09-07 Qing-Rui Wang , Zheng Zhu , Yang Qi , Zheng-Yu Weng

Force extension curves (FECs), which quantify the response of a variety of biomolecules subject to mechanical force ($f$), are often quantitatively fit using worm-like chain (WLC) or freely-jointed chain (FJC) models. These models predict…

Soft Condensed Matter · Physics 2015-06-05 Ngo Minh Toan , D. Thirumalai

Loop extrusion convincingly describes how certain Structural Maintenance of Chromosome (SMC) proteins mediate the formation of large DNA loops. Yet, most of the existing computational models cannot reconcile recent in vitro observations…

Soft Condensed Matter · Physics 2022-01-12 Andrea Bonato , Davide Michieletto

We introduce an efficient, scalable Monte Carlo algorithm to simulate cross-linked architectures of freely-jointed and discrete worm-like chains. Bond movement is based on the discrete tractrix construction, which effects conformational…

Soft Condensed Matter · Physics 2010-12-27 Henry E. Amuasi , Cornelis Storm

For a model of DNA denaturation, exponents describing the distributions of denaturated loops and unzipped end-segments are determined by exact enumeration and by Monte Carlo simulations in two and three dimensions. The loop distributions…

Statistical Mechanics · Physics 2007-05-23 Marco Baiesi , Enrico Carlon , Attilio Stella

The angular distribution of the phase space arising in two-particle emission reactions induced by electrons and neutrinos is computed in the laboratory (Lab) system by boosting the isotropic distribution in the center of mass (CM) system…

Nuclear Theory · Physics 2014-10-16 I. Ruiz Simo , C. Albertus , J. E. Amaro , M. B. Barbaro , J. A. Caballero , T. W. Donnelly

We have investigated two-electron bound state formation in a square two-dimensional t-J-U model with hopping anisotropies for zero electron density; these anisotropies are introduced to mimic the hopping energies similar to those expected…

Strongly Correlated Electrons · Physics 2009-10-31 Saurabh Basu , R. J. Gooding , P. W. Leung

Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a…

Statistical Mechanics · Physics 2011-05-02 Thomas R. Einert , Henri Orland , Roland R. Netz

Under supercoiling constraints, naked DNA, such as a large part of bacterial DNA, folds into braided structures called plectonemes. The double-helix can also undergo local structural transitions, leading to the formation of denaturation…

Biological Physics · Physics 2017-08-08 Thibaut Lepage , Ivan Junier

We analyze the probability of a single loop formation in a long flexible polymer chain in disordered environment in $d$ dimensions. The structural defects are considered to be correlated on large distances $r$ according to a power law $\sim…

Soft Condensed Matter · Physics 2016-04-14 K. Haydukivska , V. Blavatska