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A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…

Quantitative Methods · Quantitative Biology 2007-05-23 Hakho Lee , Yong Liu , Donhee Ham , Robert M. Westervelt

This paper presents an approach for understanding the soft tissue behavior in surface contact with a probe scanning the tissue. The application domain is confocal microlaparoscopy, mostly used for imaging the outer surface of the organs in…

Robotics · Computer Science 2018-04-16 M. Erden , B. Rosa , J. Szewczyk , G. Morel

Micromanipulations, perfusions and measurements performed using glass microelectrodes filled with an electrolyte is a conventional technique for experimental morphological and membrane electrophysiological studies at a single cell and…

Subcellular Processes · Quantitative Biology 2018-07-27 O. V. Gradov , P. A. Nasirov , A. A. Scrynnic , A. G. Jablokov

We describe here the implementation of an interferometer-based microwave impedance microscope on a home-built tuning-fork based scanning probe microscope (SPM). Tuning-fork based SPMs, requiring only two electrical contacts for…

Applied Physics · Physics 2020-07-14 Z. Liu , P. W. Krantz , V. Chandrasekhar

A home made DSP-controlled scanning probe microscope (SPM) system has been developed and its utilization as a tool for lithography on nanometer scale is reported. User-friendly graphic interface allows to directly perform nanolithography…

Materials Science · Physics 2007-05-23 Pasqualantonio Pingue , Paolo Baschieri , Cesare Ascoli , Michel Dayez

Encapsulation of chemicals using polymer membranes enables to control their transport and delivery for applications such as agrochemistry or detergency. To rationalize the design of polymer capsules, it is necessary to understand how the…

Soft Condensed Matter · Physics 2018-12-18 Corentin Tregouët , Thomas Salez , Mathilde Reyssat , Cécile Monteux

A novel scanning probe technique is presented: Scanning microSQUID Force microscopy (SSFM). The instrument features independent topographic and magnetic imaging. The SSFM operates in a dilution refrigerator in cryogenic vacuum. Sample and…

Superconductivity · Physics 2007-05-23 C. Veauvy , D. Mailly , K. Hasselbach

We report on a non-interacting technique for thermal characterization of fluids based on surface plasmon resonance interrogation. Using liquid volumes less than 20 micro liters we have determined the materials' thermo-optic coefficients…

Optics · Physics 2015-05-20 Lawrence Davis , Miriam Deutsch

An X-ray detector will be presented that is the combination of a segmented ionization chamber featuring one-dimensional spatial resolution integrated with an intelligent ADC front-end, multi DSP processing and embedded PC platform. This…

Instrumentation and Detectors · Physics 2010-01-26 Francesco Voltolina , Ralf H. Menk , Sergio Carrato

Dissipative Particle Dynamics (DPD) is becoming a popular particle based method to study flow through microchannels due to the ease with which the presence of biological cells or DNA chains can be modeled. Many Lab-On-Chip (LOC) devices…

Fluid Dynamics · Physics 2013-03-27 S. Kumar Ranjith , B. S. V. Patnaik , Srikanth Vedantam

Pumping fluids without an aid of an external power source are desirable in a number of applications ranging from a cooling of microelectronic circuits to Micro Total Analysis Systems (micro-TAS). Although, several microfluidic pumps exist,…

Applied Physics · Physics 2019-09-25 Prasoon Kumar , Prasanna S Gandhi , Mainak Majumder

Surface assays such as ELISA are pervasive in clinics and research and predominantly standardized in microtiter plates (MTP). MTPs provide many advantages but are often detrimental to surface assay efficiency due to inherent mass transport…

Biomolecules · Quantitative Biology 2022-02-08 Iago Pereiro , Anna Fomitcheva Khartchenko , Robert D. Lovchik , Govind V. Kaigala

We demonstrate a cryogenic scanned probe microscope (SPM) that has been modified to be controlled with a haptic device, such that the operator can `feel' the surface of a sample under investigation. This system allows for direct tactile…

Instrumentation and Detectors · Physics 2022-08-29 Maxwell Freeman , Rhett Applestone , Wyatt Behn , Victor Brar

Strong control over experimental conditions in microfluidic channels provides a unique opportunity to study and optimize membraneless microbial fuel cells (MFCs), particularly with respect to the role of flow. However, improved performance…

MFC is an open-source tool for solving multi-component, multi-phase, and bubbly compressible flows. It is capable of efficiently solving a wide range of flows, including droplet atomization, shock-bubble interaction, and gas bubble…

Computational Physics · Physics 2020-08-19 Spencer H. Bryngelson , Kevin Schmidmayer , Vedran Coralic , Jomela C. Meng , Kazuki Maeda , Tim Colonius

Polydimethylsiloxane (PDMS) microfluidic devices have become a standard tool for engineering cells and multicellular networks in vitro. However, the reservoirs, or through-holes where cells access the devices, are usually fabricated…

Applied Physics · Physics 2020-12-02 Taiki Takemuro , Hideaki Yamamoto , Shigeo Sato , Ayumi Hirano-Iwata

Computational fluid dynamics (CFD) in many cases requires designing 3D models manually, which is a tedious task that requires specific skills. In this paper, we present a novel method for performing CFD directly on scanned 3D point clouds.…

Modern machine learning (ML) models of chemical and materials systems with billions of parameters require vast training datasets and considerable computational efforts. Lightweight kernel or decision tree based methods, however, can be…

Chemical Physics · Physics 2024-10-18 Danish Khan , O. Anatole von Lilienfeld

Microfluidics have emerged as a vital tool in various scientific and engineering applications, ranging from biomedical diagnostics to chemical analysis. However, conventional fabrication methods often necessitate costly equipment and…

Instrumentation and Detectors · Physics 2023-08-07 Habilou Ouro-Koura , Ayobami Ogunmolasuyi , Othman Suleiman , Kausik S Das

Traditional detection methods of C-reactive protein (CRP) inflammation biomarker, in blood are expensive, time-consuming and labor-intensive. Such existing point-of-care CRP detection devices remain invasive, since they need blood sampling…

Medical Physics · Physics 2024-07-25 Aristea Grammoustianou , Ali Saeidi , Johan Longo , Felix Risch , Adrian M. Ionescu