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In the treatment plan optimization for intensity modulated radiation therapy (IMRT), dose-deposition coefficient (DDC) matrix is often pre-computed to parameterize the dose contribution to each voxel in the volume of interest from each…

Medical Physics · Physics 2013-03-15 Zhen Tian , Masoud Zarepisheh , Xun Jia , Steve B. Jiang

Accurate models of clinical actions and their impacts on disease progression are critical for estimating personalized optimal dynamic treatment regimes (DTRs) in medical/health research, especially in managing chronic conditions.…

Methodology · Statistics 2021-02-19 William Hua , Hongyuan Mei , Sarah Zohar , Magali Giral , Yanxun Xu

Semidefinite programs (SDPs) are a fundamental class of optimization problems with important recent applications in approximation algorithms, quantum complexity, robust learning, algorithmic rounding, and adversarial deep learning. This…

Data Structures and Algorithms · Computer Science 2020-09-23 Haotian Jiang , Tarun Kathuria , Yin Tat Lee , Swati Padmanabhan , Zhao Song

Motion planning in high-dimensional space is a challenging task. In order to perform dexterous manipulation in an unstructured environment, a robot with many degrees of freedom is usually necessary, which also complicates its motion…

Robotics · Computer Science 2021-08-03 Chao Liu , Mark Yim

We establish a broad methodological foundation for mixed-integer optimization with learned constraints. We propose an end-to-end pipeline for data-driven decision making in which constraints and objectives are directly learned from data…

Optimization and Control · Mathematics 2023-10-30 Donato Maragno , Holly Wiberg , Dimitris Bertsimas , S. Ilker Birbil , Dick den Hertog , Adejuyigbe Fajemisin

The demand for classical-quantum hybrid algorithms to solve large-scale combinatorial optimization problems using quantum annealing (QA) has increased. One approach involves obtaining an approximate solution using classical algorithms and…

Quantum Physics · Physics 2024-11-12 Taisei Takabayashi , Masayuki Ohzeki

While many approaches have been proposed to analyze the problem of matrix multiplication parallel computing, few of them address the problem on heterogeneous processor platforms. It still remains an open question on heterogeneous processor…

Networking and Internet Architecture · Computer Science 2018-12-18 Yang Liu , Li Shi , Junwei Zhang , Thomas G. Robertazzi

One of the main goals of sequential, multiple assignment, randomized trials (SMART) is to find the most efficacious design embedded dynamic treatment regimes. The analysis method known as multiple comparisons with the best (MCB) allows…

Methodology · Statistics 2020-08-07 William J. Artman , Ashkan Ertefaie , Kevin G. Lynch , James R. McKay

We present a new mixed integer formulation for the discrete informative path planning problem in random fields. The objective is to compute a budget constrained path while collecting measurements whose linear estimate results in minimum…

Systems and Control · Electrical Eng. & Systems 2022-04-21 Shamak Dutta , Nils Wilde , Stephen L. Smith

Constrained convex optimization problems arise naturally in many real-world applications. One strategy to solve them in an approximate way is to translate them into a sequence of convex feasibility problems via the recently developed level…

Optimization and Control · Mathematics 2019-04-30 E. Bonacker , A. Gibali , K. -H. Küfer

In light of the increasing coupling between electricity and gas networks, this paper introduces two novel iterative methods for efficiently solving the multiperiod optimal electricity and gas flow (MOEGF) problem. The first is an iterative…

Optimization and Control · Mathematics 2021-06-28 Sleiman Mhanna , Isam Saedi , Pierluigi Mancarella

As rapidly growing AI computational demands accelerate the need for new hardware installation and maintenance, this work explores optimal data center resource management by balancing operational efficiency with fault tolerance through…

Artificial Intelligence · Computer Science 2025-04-02 Chang-Lin Chen , Jiayu Chen , Tian Lan , Zhaoxia Zhao , Hongbo Dong , Vaneet Aggarwal

Inverse optimization, determining parameters of an optimization problem that render a given solution optimal, has received increasing attention in recent years. While significant inverse optimization literature exists for convex…

Optimization and Control · Mathematics 2021-09-02 Merve Bodur , Timothy C. Y. Chan , Ian Yihang Zhu

The size and complexity of modern astronomical surveys has grown to the point where, in many cases, traditional human scheduling of observations are tedious at best and impractical at worst. Automated scheduling algorithms present an…

Instrumentation and Methods for Astrophysics · Physics 2023-10-31 Luke B. Handley , Erik A. Petigura , Velibor V. Misic

Planning in hybrid systems with both discrete and continuous control variables is important for dealing with real-world applications such as extra-planetary exploration and multi-vehicle transportation systems. Meanwhile, generating…

Robotics · Computer Science 2021-02-23 Jingkai Chen , Brian Williams , Chuchu Fan

This paper proposes a novel methodology for trajectory planning in autonomous vehicles (AVs), addressing the complex challenge of negotiating speed bumps within a unified Mixed-Integer Quadratic Programming (MIQP) framework. By leveraging…

Mixed-Integer Linear Programming (MILP) plays an important role across a range of scientific disciplines and within areas of strategic importance to society. The MILP problems, however, suffer from combinatorial complexity. Because of…

Optimization and Control · Mathematics 2023-01-06 Mikhail A. Bragin , Emily L. Tucker

We present a depth-aware optimization framework for quantum circuit compilation that unifies provable optimality with scalable heuristics. For exact synthesis of a target unitary, we formulate a mixed-integer linear program (MILP) that…

Quantum Physics · Physics 2025-10-02 Harsha Nagarajan , Zsolt Szabó

It has been verified that the linear programming (LP) is able to formulate many real-life optimization problems, which can obtain the optimum by resorting to corresponding solvers such as OptVerse, Gurobi and CPLEX. In the past decades, a…

Optimization and Control · Mathematics 2022-01-19 Xijun Li , Qingyu Qu , Fangzhou Zhu , Jia Zeng , Mingxuan Yuan , Kun Mao , Jie Wang

In hybrid Model Predictive Control (MPC), a Mixed-Integer Quadratic Program (MIQP) is solved at each sampling time to compute the optimal control action. Although these optimizations are generally very demanding, in MPC we expect…

Systems and Control · Electrical Eng. & Systems 2020-04-01 Tobia Marcucci , Russ Tedrake