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Most traditional models of uncertainty have focused on the associational relationship among variables as captured by conditional dependence. In order to successfully manage intelligent systems for decision making, however, we must be able…

Artificial Intelligence · Computer Science 2015-05-19 David Heckerman , Ross D. Shachter

Recent developments in the formalisation of quantum causal structures have made it possible to test and compare hypotheses about causal structure empirically, rather than being a-priori assumptions. Such differences in causal structure may…

Quantum Physics · Physics 2026-05-28 Declan Maguire , Fabio Costa

Bivariate structural causal models (SCM) are often used to infer causal direction by examining their goodness-of-fit under restricted model classes. In this paper, we describe a parametrization of bivariate SCMs in terms of a causal…

Machine Learning · Statistics 2025-06-11 Johnny Xi , Hugh Dance , Peter Orbanz , Benjamin Bloem-Reddy

Event Structures (ESs) address the representation of direct relationships between individual events, usually capturing the notions of causality and conflict. Up to now, such relationships have been static, i.e., they cannot change during a…

Logic in Computer Science · Computer Science 2023-06-22 Youssef Arbach , David S. Karcher , Kirstin Peters , Uwe Nestmann

We provide linearizability criteria for a class of systems of third-order ordinary differential equations (ODEs) that is cubically semi-linear in the first derivative, by differentiating a system of second-order quadratically semi-linear…

Classical Analysis and ODEs · Mathematics 2015-05-13 F. M. Mahomed , I. Naeem , Asghar Qadir

Explanatory studies, such as randomized controlled trials, are targeted to extract the true causal effect of interventions on outcomes and are by design adjusted for covariates through randomization. On the contrary, observational studies…

Methodology · Statistics 2022-05-02 Riddhiman Adib , Sheikh Iqbal Ahamed , Mohammad Adibuzzaman

Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about…

Quantitative Methods · Quantitative Biology 2018-10-12 Fabian Fröhlich , Carolin Loos , Jan Hasenauer

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

The paper concerns the problem of predicting the effect of actions or interventions on a system from a combination of (i) statistical data on a set of observed variables, and (ii) qualitative causal knowledge encoded in the form of a…

Artificial Intelligence · Computer Science 2012-07-02 Carlos Brito , Judea Pearl

A predictive model makes outcome predictions based on some given features, i.e., it estimates the conditional probability of the outcome given a feature vector. In general, a predictive model cannot estimate the causal effect of a feature…

Machine Learning · Computer Science 2023-04-11 Jiuyong Li , Lin Liu , Ziqi Xu , Ha Xuan Tran , Thuc Duy Le , Jixue Liu

Deep generative models have shown tremendous capability in data density estimation and data generation from finite samples. While these models have shown impressive performance by learning correlations among features in the data, some…

Machine Learning · Computer Science 2024-05-24 Aneesh Komanduri , Xintao Wu , Yongkai Wu , Feng Chen

For decades, researchers in fields, such as the natural and social sciences, have been verifying causal relationships and investigating hypotheses that are now well-established or understood as truth. These causal mechanisms are properties…

Machine Learning · Computer Science 2019-12-02 Trent Kyono , Mihaela van der Schaar

We discuss the role and merits of symmetry methods for the analysis of biological systems. In particular, we consider systems of first order ordinary differential equations and provide a comprehensive review of the geometrical foundations…

Quantitative Methods · Quantitative Biology 2022-02-11 Johannes Borgqvist , Fredrik Ohlsson , Ruth E. Baker

Causal structure learning with data from multiple contexts carries both opportunities and challenges. Opportunities arise from considering shared and context-specific causal graphs enabling to generalize and transfer causal knowledge across…

Machine Learning · Computer Science 2024-10-29 Martin Rabel , Wiebke Günther , Jakob Runge , Andreas Gerhardus

Many real-world systems can be usefully represented as sets of interacting components. Examples include computational systems, such as query processors and compilers, natural systems, such as cells and ecosystems, and social systems, such…

Artificial Intelligence · Computer Science 2025-03-18 Purva Pruthi , David Jensen

Stochasticity plays a key role in many biological systems, necessitating the calibration of stochastic mathematical models to interpret associated data. For model parameters to be estimated reliably, it is typically the case that they must…

Structural Causal Explanations (SCEs) can be used to automatically generate explanations in natural language to questions about given data that are grounded in a (possibly learned) causal model. Unfortunately they work for small data only.…

Artificial Intelligence · Computer Science 2025-06-05 Sebastian Rödling , Matej Zečević , Devendra Singh Dhami , Kristian Kersting

Here we introduce Partially Observed Structural Causal Models (POSCMs) that formalize causal systems where latent contexts co-determine both the interaction structure and downstream mechanisms on observed variables. POSCMs provide an…

Machine Learning · Computer Science 2026-05-06 Turan Orujlu , Jordan Matelsky , Martin V. Butz , Charley M. Wu , Konrad P. Kording

This book explores an alternative to the current dominant paradigm where a discrete computer model is constructed as an attempt to approximate some continuum theory. We focus on a class of discrete computer models that are based on simple…

Logic in Computer Science · Computer Science 2017-04-14 Garry Pantelis

Conditional density estimation (CDE) models can be useful for many statistical applications, especially because the full conditional density is estimated instead of traditional regression point estimates, revealing more information about…

Methodology · Statistics 2021-07-12 Alex Akira Okuno , Felipe Maia Polo