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Unnatural dynamics of the notorious vortex in the left ventricle is often associated with cardiac disease. Understanding how different cardiac diseases alter the flow physics in the left ventricle may therefore provide a powerful tool for…

Medical Physics · Physics 2019-03-18 Giuseppe Di Labbio , Lyes Kadem

This Artificial left ventricle is based on a simple conic assumption shape for left ventricle where its motion is made by attached compressed elastic tubes to its walls which are regarded to electrical points at each nodal .This compressed…

Medical Physics · Physics 2014-08-05 Saeed Ranjbar , Tohid Emami Meybodi , Mahmood Emami Meybodi

A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude…

Medical Physics · Physics 2007-05-23 S. Dubi , C. Dubi , Y. Dubi

Recently, the ventricular torsional parameters have received special attention because of their significant role in the ventricular systolic and diastolic function. Right ventricular (RV) rotational deformation is a sensitive index for RV…

Medical Physics · Physics 2015-04-22 Saeed Ranjbar

Every sixth death in industrialised countries occurs because of cardiac arrhythmias like ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of…

Pattern Formation and Solitons · Physics 2007-05-23 T K Shajahan , Sitabhra Sinha , Rahul Pandit

Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of…

Pattern Formation and Solitons · Physics 2007-05-23 T. K. Shajahan , Sitabhra Sinha , Rahul Pandit

The left ventricular end-systolic pressure-volume relationship (ESPVr) is a key indicator of cardiac contractility. Despite its established importance, several studies suggested that the mechanical mode of contraction, such as isovolumetric…

Medical Physics · Physics 2024-11-12 Francesco Regazzoni , Corrado Poggesi , Cecilia Ferrantini

The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…

Fluid Dynamics · Physics 2021-03-30 Francesco Viola , Valentina Meschini , Roberto Verzicco

One of the challenges in the development of patient-specific models of cardiac arrhythmias for clinical applications has been accounting for myocardial fiber organization. The fiber varies significantly from heart to heart, but cannot be…

Medical Physics · Physics 2023-07-22 Jiyue He , Arkady Pertsov , John Bullinga , Rahul Mangharam

Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…

We present a reduced-order heart model with the aim of introducing a novel point of view in the interpretation of the pressure-volume loops. The novelty of the approach is based on the definition of active contraction as opposed to that of…

Tissues and Organs · Quantitative Biology 2010-05-31 Paola Nardinocchi , Luciano Teresi , Valerio Varano

Accurate assessment of myocardial tissue stiffness is pivotal for the diagnosis and prognosis of heart diseases. Left ventricular diastolic stiffness ($\beta$) obtained from the end-diastolic pressure-volume relationship (EDPVR) has…

We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging…

Fluid Dynamics · Physics 2015-05-30 Trung Le , Fotis Sotiropoulos , Dane Coffey , Daniel Keefe

Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac…

Medical Physics · Physics 2014-06-25 Saeed Ranjbar , Mersedeh Karvandi

In this paper it will be shown that according to the scheme theory in algebraic geometry, human heart as an elastic body can be represented as a 3D scheme, on account of algebraic equations of the myocardial fibers as the local parts of the…

Tissues and Organs · Quantitative Biology 2015-12-16 Saeed Ranjbar , Mersedeh Karvandi

The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…

Fluid Dynamics · Physics 2014-07-29 S. Fortini , G. Querzoli , S. Espa , A. Cenedese

Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber…

Analysis of PDEs · Mathematics 2008-12-04 Christian Bourdarias , Stéphane Gerbi , Jacques Ohayon

Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in…

In this work we propose a mathematical model that describes the orientation of ventricular cardiac fibers. These fibers are commonly computed as the normalized gradient of certain harmonic potentials, so our work consisted in finding the…

Numerical Analysis · Mathematics 2023-05-03 Nicolás A. Barnafi , Axel Osses

Left ventricular (LV) stiffness and contractility, characterized by the end-diastolic and end-systolic pressure-volume relationships (EDPVR & ESPVR), are two important indicators of the performance of the human heart. Although much research…

Medical Physics · Physics 2023-08-22 Yunxiao Zhang , Moritz Kalhöfer-Köchling , Eberhard Bodenschatz , Yong Wang
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