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To interpret molecular dynamics simulations of biomolecular systems, systematic dimensionality reduction methods are commonly employed. Among others, this includes principal component analysis (PCA) and time-lagged independent component…

Biomolecules · Quantitative Biology 2022-07-20 Georg Diez , Daniel Nagel , Gerhard Stock

Sparse principal component analysis (PCA) is an important technique for dimensionality reduction of high-dimensional data. However, most existing sparse PCA algorithms are based on non-convex optimization, which provide little guarantee on…

Methodology · Statistics 2019-11-20 Yixuan Qiu , Jing Lei , Kathryn Roeder

We present a novel technique to discover and exploit weak causal signals directly from images via neural networks for classification purposes. This way, we model how the presence of a feature in one part of the image affects the appearance…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Gianluca Carloni , Sara Colantonio

The segmentation of medical images is a fundamental step in automated clinical decision support systems. Existing medical image segmentation methods based on supervised deep learning, however, remain problematic because of their reliance on…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Euijoon Ahn , Dagan Feng , Jinman Kim

Sparse Bayesian learning is a state-of-the-art supervised learning algorithm that can choose a subset of relevant samples from the input data and make reliable probabilistic predictions. However, in the presence of high-dimensional data…

Machine Learning · Computer Science 2020-01-10 Bingbing Jiang , Chang Li , Maarten de Rijke , Xin Yao , Huanhuan Chen

Predictive marker patterns in imaging data are a means to quantify disease and progression, but their identification is challenging, if the underlying biology is poorly understood. Here, we present a method to identify predictive texture…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 Matthias Perkonigg , Daniel Sobotka , Ahmed Ba-Ssalamah , Georg Langs

Medical image segmentation demands an efficient and robust segmentation algorithm against noise. The conventional fuzzy c-means algorithm is an efficient clustering algorithm that is used in medical image segmentation. But FCM is highly…

Computer Vision and Pattern Recognition · Computer Science 2010-04-13 S. Zulaikha Beevi , M. Mohammed Sathik , K. Senthamaraikannan

Regularized variants of Principal Components Analysis, especially Sparse PCA and Functional PCA, are among the most useful tools for the analysis of complex high-dimensional data. Many examples of massive data, have both sparse and…

Machine Learning · Statistics 2019-08-21 Genevera I. Allen , Michael Weylandt

Sparse principal component analysis (SPCA) has emerged as a powerful technique for modern data analysis, providing improved interpretation of low-rank structures by identifying localized spatial structures in the data and disambiguating…

Recent advances in neuroimaging analysis have enabled accurate decoding of mental state from brain activation patterns during functional magnetic resonance imaging scans. A commonly applied tool for this purpose is principal components…

Machine Learning · Statistics 2025-09-10 Jared Rieck , Julia Wrobel , Joshua L. Gowin , Yue Wang , Martin Paulus , Ryan Peterson

Principal Component Analysis (PCA) is a widely utilized technique for dimensionality reduction; however, its inherent lack of interpretability-stemming from dense linear combinations of all feature-limits its applicability in many domains.…

Machine Learning · Computer Science 2025-04-01 Loc Hoang Tran

Principal Component Analysis (PCA) is the most widely used tool for linear dimensionality reduction and clustering. Still it is highly sensitive to outliers and does not scale well with respect to the number of data samples. Robust PCA…

Computer Vision and Pattern Recognition · Computer Science 2015-04-24 Nauman Shahid , Vassilis Kalofolias , Xavier Bresson , Michael Bronstein , Pierre Vandergheynst

A new model-based procedure is developed for sparse clustering of functional data that aims to classify a sample of curves into homogeneous groups while jointly detecting the most informative portions of domain. The proposed method is…

Methodology · Statistics 2023-10-04 Fabio Centofanti , Antonio Lepore , Biagio Palumbo

Feature selection (FS) is a process which attempts to select more informative features. In some cases, too many redundant or irrelevant features may overpower main features for classification. Feature selection can remedy this problem and…

Machine Learning · Computer Science 2013-06-07 A. Nisthana Parveen , H. Hannah Inbarani , E. N. Sathishkumar

In several application domains, high-dimensional observations are collected and then analysed in search for naturally occurring data clusters which might provide further insights about the nature of the problem. In this paper we describe a…

Machine Learning · Statistics 2012-03-07 Brian McWilliams , Giovanni Montana

Functional data analysis (FDA) methods have computational and theoretical appeals for some high dimensional data, but lack the scalability to modern large sample datasets. To tackle the challenge, we develop randomized algorithms for two…

Computation · Statistics 2022-04-11 Shiyuan He , Xiaomeng Yan

In this paper, we consider clustering based on principal component analysis (PCA) for high-dimension, low-sample-size (HDLSS) data. We give theoretical reasons why PCA is effective for clustering HDLSS data. First, we derive a geometric…

Statistics Theory · Mathematics 2015-03-17 Kazuyoshi Yata , Makoto Aoshima

Medical imaging involves high-dimensional data, yet their acquisition is obtained for limited samples. Multivariate predictive models have become popular in the last decades to fit some external variables from imaging data, and standard…

Applications · Statistics 2018-06-18 Jérôme-Alexis Chevalier , Joseph Salmon , Bertrand Thirion

Sparse functional data arise when measurements are observed infrequently and at irregular time points for each subject, often in the presence of measurement error. These characteristics introduce additional challenges for functional…

Methodology · Statistics 2026-03-20 Uche Mbaka , Jiguo Cao , Michelle Carey

A crucial step in single particle analysis (SPA) of cryogenic electron microscopy (Cryo-EM), 2D classification and alignment takes a collection of noisy particle images to infer orientations and group similar images together. Averaging…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Supawit Chockchowwat , Chandrajit L. Bajaj