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Few analytical methods exist for quantitative studies of large fluctuations in stochastic systems. In this article, we develop a simple diagrammatic approach to the Chemical Master Equation that allows us to calculate multi-time correlation…

Statistical Mechanics · Physics 2015-06-22 Philipp Thomas , Christian Fleck , Ramon Grima , Nikola Popović

The dynamics of one species chemical kinetics is studied. Chemical reactions are modelled by means of continuous time Markov processes whose probability distribution obeys a suitable master equation. A large deviation theory is formally…

Statistical Mechanics · Physics 2015-03-14 Carlos Escudero , Andres M. Rivera , Pedro J. Torres

The Chemical Master Equation (CME) is used to stochastically model biochemical reaction networks, under the Markovian assumption. The low-order statistical moments induced by the CME are often the key quantities that one is interested in.…

Systems and Control · Computer Science 2017-07-04 Mohammad Naghnaeian , Domitilla Del Vecchio

The ability to quantify stochastic fluctuations present in biochemical and other systems is becoming increasing important. Analytical descriptions of these fluctuations are attractive, as stochastic simulations are computationally…

Statistical Mechanics · Physics 2013-02-07 Joseph D. Challenger , Alan J. McKane , Jürgen Pahle

The chemical master equation (CME) is the exact mathematical formulation of chemical reactions occurring in a dilute and well-mixed volume. The reaction-diffusion master equation (RDME) is a stochastic description of reaction-diffusion…

Chemical Physics · Physics 2016-06-22 Stephen Smith , Ramon Grima

We analyze a class of chemical reaction networks under mass-action kinetics and involving multiple time-scales, whose deterministic and stochastic models display qualitative differences. The networks are inspired by gene-regulatory…

Molecular Networks · Quantitative Biology 2018-01-30 Tomislav Plesa , Radek Erban , Hans G. Othmer

In synaptic molecular communication, the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process and, hence, inherently random. It is currently not fully understood how this…

Emerging Technologies · Computer Science 2023-01-18 Sebastian Lotter , Maximilian Schäfer , Robert Schober

In this paper, we investigate a Langevin model subjected to stochastic intensity noise (SIN), which incorporates temporal fluctuations in noise-intensity. We derive a higher-order Fokker-Planck equation (HFPE) of the system, taking into…

Statistical Mechanics · Physics 2011-01-25 Yoshihiko Hasegawa , Masanori Arita

The analysis of noise-induced escape in populations of bistable elements is challenging, because nonlinearity, coupling, and noise all play essential roles. We show that the interplay of these three factors yields three qualitatively…

Adaptation and Self-Organizing Systems · Physics 2026-03-06 Hidemasa Ishii , Hiroshi Kori

We explore the chaotic dynamics and complexity of a neuro-system with respect to variable synaptic weights in both noise free and noisy conditions. The chaotic dynamics of the system is investigated by bifurcation analysis and 0-1 test. A…

Chaotic Dynamics · Physics 2021-03-17 Sanjay K. Palit , Sayan Mukherjee

Integrated Computational Materials Engineering (ICME) models have been a crucial building block for modern materials development, relieving heavy reliance on experiments and significantly accelerating the materials design process. However,…

Computational Engineering, Finance, and Science · Computer Science 2022-03-10 Anh Tran , Jing Sun , Dehao Liu , Tim Wildey , Yan Wang

There has been a long-standing and at times fractious debate whether complex and large systems can be stable. In ecology, the so-called `diversity-stability debate' arose because mathematical analyses of ecosystem stability were either…

Dynamical Systems · Mathematics 2015-09-02 Paul Kirk , Delphine M. Y. Rolando , Adam L. MacLean , Michael P. H. Stumpf

It is well known that the kinetics of an intracellular biochemical network is stochastic. This is due to intrinsic noise arising from the random timing of biochemical reactions in the network as well as due to extrinsic noise stemming from…

Subcellular Processes · Quantitative Biology 2019-06-05 Emma M. Keizer , Bjorn Bastian , Robert W. Smith , Ramon Grima , Christian Fleck

Research on stochastic differential equations (SDE) involving both additive and multiplicative noise has been extensive. In situations where the primary process is driven by a multiplicative stochastic process, additive white noise…

Statistics Theory · Mathematics 2024-04-23 Marco Bianucci , Mauro Bologna , Riccardo Mannella

We consider rare transitions induced by colored noise excitation in multistable systems. We show that undesirable transitions can be mitigated by a simple time-delay feedback control if the control parameters are judiciously chosen. We…

Dynamical Systems · Mathematics 2021-09-15 Konstantinos Mamis , Mohammad Farazmand

The classical Fokker-Planck equation (FPE) is a key tool in physics for describing systems influenced by drag forces and Gaussian noise, with applications spanning multiple fields. We consider the fractional Fokker-Planck equation (FFPE),…

Numerical Analysis · Mathematics 2026-04-30 Qihao Ye , Xiaochuan Tian , Dong Wang

We introduce a new method, allowing to describe slowly time-dependent Langevin equations through the behaviour of individual paths. This approach yields considerably more information than the computation of the probability density. The main…

Statistical Mechanics · Physics 2007-05-23 Nils Berglund , Barbara Gentz

Ordinary differential equation models are used to describe dynamic processes across biology. To perform likelihood-based parameter inference on these models, it is necessary to specify a statistical process representing the contribution of…

The study of the noise induced effects on the dynamics of a chain molecule crossing a potential barrier, in the presence of a metastable state, is presented. A two-dimensional stochastic version of the Rouse model for a flexible polymer has…

Statistical Mechanics · Physics 2015-05-13 N. Pizzolato , A. Fiasconaro , B. Spagnolo

We study an approximation scheme based on a second quantization method for a chemical master equation. Small systems, such as cells, could not be studied by the traditional rate equation approach because fluctuation effects are very large…

Chemical Physics · Physics 2010-06-18 Jun Ohkubo