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The era of big data is coming, and evidence-based medicine is attracting increasing attention to improve decision making in medical practice via integrating evidence from well designed and conducted clinical research. Meta-analysis is a…

Methodology · Statistics 2016-10-05 Dehui Luo , Xiang Wan , Jiming Liu , Tiejun Tong

Researchers increasingly use meta-analysis to synthesize the results of several studies in order to estimate a common effect. When the outcome variable is continuous, standard meta-analytic approaches assume that the primary studies report…

In some clinical studies, researchers may report the five number summary (including the sample median, the first and third quartiles, and the minimum and maximum values) rather than the sample mean and standard deviation. To conduct…

Methodology · Statistics 2018-01-08 Jiandong Shi , Dehui Luo , Hong Weng , Xian-Tao Zeng , Lu Lin , Tiejun Tong

When reporting the results of clinical studies, some researchers may choose the five-number summary (including the sample median, the first and third quartiles, and the minimum and maximum values) rather than the sample mean and standard…

Methodology · Statistics 2020-06-18 Jiandong Shi , Dehui Luo , Hong Weng , Xian-Tao Zeng , Lu Lin , Haitao Chu , Tiejun Tong

We consider the setting of an aggregate data meta-analysis of a continuous outcome of interest. When the distribution of the outcome is skewed, it is often the case that some primary studies report the sample mean and standard deviation of…

This short note proposes two additive corrections to a pair of relations published in Wan et al. in order to extend them to a small sample size condition. In particular we focus the interest on the possibility to provide an estimate to the…

Applications · Statistics 2023-10-20 Massimo Borelli

As the most important tool to provide high-level evidence-based medicine, researchers can statistically summarize and combine data from multiple studies by conducting meta-analysis. In meta-analysis, mean differences are frequently used…

Methodology · Statistics 2018-01-30 Dehui Luo , Xiang Wan , Jiming Liu , Tiejun Tong

We consider the problem of meta-analyzing two-group studies that report the median of the outcome. Often, these studies are excluded from meta-analysis because there are no well-established statistical methods to pool the difference of…

Methodology · Statistics 2022-06-22 Sean McGrath , Hojoon Sohn , Russell Steele , Andrea Benedetti

For clinical studies with continuous outcomes, when the data are potentially skewed, researchers may choose to report the whole or part of the five-number summary (the sample median, the first and third quartiles, and the minimum and…

Methodology · Statistics 2023-05-09 Jiandong Shi , Dehui Luo , Xiang Wan , Yue Liu , Jiming Liu , Zhaoxiang Bian , Tiejun Tong

Meta-analysis is the aggregation of data from multiple studies to find patterns across a broad range relating to a particular subject. It is becoming increasingly useful to apply meta-analysis to summarize these studies being done across…

Methodology · Statistics 2023-10-25 Olivia Xiao , Stacy Wang , Min Chen

Meta-analysis involves combining summary information for related but independent studies. It uses different relationship to combine position measure as well as dispersion measures. The objective of this study is to discuss a relationship…

Methodology · Statistics 2012-02-07 Jose Fausto de Morais

Statistical samples, in order to be representative, have to be drawn from a population in a random and unbiased way. Nevertheless, it is common practice in the field of model-based diagnosis to make estimations from (biased) best-first…

Artificial Intelligence · Computer Science 2022-08-05 Patrick Rodler , Fatima Elichanova

A popular setting in medical statistics is a group sequential trial with independent and identically distributed normal outcomes, in which interim analyses of the sum of the outcomes are performed. Based on a prescribed stopping rule, one…

Statistics Theory · Mathematics 2018-04-03 Ben Berckmoes , Anna Ivanova , Geert Molenberghs

An aggregate data meta-analysis is a statistical method that pools the summary statistics of several selected studies to estimate the outcome of interest. When considering a continuous outcome, typically each study must report the same…

Methodology · Statistics 2022-06-22 Sean McGrath , XiaoFei Zhao , Zhi Zhen Qin , Russell Steele , Andrea Benedetti

The sample mean is often used to aggregate different unbiased estimates of a parameter, producing a final estimate that is unbiased but possibly high-variance. This paper introduces the Bayesian median of means, an aggregation rule that…

Statistics Theory · Mathematics 2019-06-05 Paulo Orenstein

Background: When conducting a meta-analysis of a continuous outcome, estimated means and standard deviations from the selected studies are required in order to obtain an overall estimate of the mean effect and its confidence interval. If…

Methodology · Statistics 2020-04-07 Deukwoo Kwon , Isildinha M. Reis

While there exists a large amount of literature on the general challenges of and best practices for trustworthy online A/B testing, there are limited studies on sample size estimation, which plays a crucial role in trustworthy and efficient…

Methodology · Statistics 2023-08-21 Jing Zhou , Jiannan Lu , Anas Shallah

We review the alternative proposals introduced recently in the literature to update the standard formula to estimate the uncertainty on the mean of repeated measurements, and we compare their performances on synthetic examples with normal…

Data Analysis, Statistics and Probability · Physics 2022-09-13 Pascal Pernot , Jean-Paul Berthet

For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size calculation requires specification of the variance other than…

Methodology · Statistics 2026-02-04 Hirotada Maeda , Satoshi Hattori , Tim Friede

This paper proposes a Bayesian method for estimating the parameters of a normal distribution when only limited summary statistics (sample mean, minimum, maximum, and sample size) are available. To estimate the parameters of a normal…

Methodology · Statistics 2024-11-21 Tomoki Matsumoto
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