Related papers: Optimizing control of HIV in Kenya

The precise mechanism that causes HIV infection to progress to AIDS is still unknown. This paper presents a mathematical model which is able to predict the entire trajectory of the HIV/AIDS dynamics, then a possible explanation for this…

Cervical cancer will cause 460 000 deaths per year by 2040, approximately 90% are Sub-Saharan African women. A constantly increasing incidence in Africa making cervical cancer a priority by the World Health Organization (WHO) in terms of…

We present statistical techniques for analyzing global positioning system (GPS) data in order to understand, communicate about, and prevent patterns of violence. In this pilot study, participants in Nairobi, Kenya were asked to rate their…

Female sex workers(FSWs) are one of the most vulnerable and stigmatized groups in society. As a result, they often suffer from a lack of quality access to care. Grassroot organizations engaged in improving health services are often faced…

In people infected with HIV the RNA viral load is a good predictor of the rate of loss of CD4 cells at a population level but there is still great variability in the rate of decline of CD4 cells among individuals. Here we show that the…

We evaluate the efficiency of various heuristic strategies for allocating vaccines against COVID-19 and compare them to strategies found using optimal control theory. Our approach is based on a mathematical model which tracks the spread of…

Background. Several studies have used phylogenetics to investigate Human Immunodeficiency Virus (HIV) transmission among Men who have Sex with Men (MSMs) in Montreal, Quebec, Canada, revealing many transmission clusters. The Quebec HIV…

OBJECTIVE: To propose a new approach to analyze the age-distribution of reported cases for vector-transmitted infections. METHODS: Using officially reported number of cases of dengue, Zika, chikungunya, malaria and leishmaniasis for…

Evaluation of HIV large scale interventions programme is becoming increasingly important, but impact estimates frequently hinge on knowledge of changes in behaviour such as the frequency of condom use (CU) over time, or other self-reported…

Like many chronic diseases, human immunodeficiency virus (HIV) is managed over time at regular clinic visits. At each visit, patient features are assessed, treatments are prescribed, and a subsequent visit is scheduled. There is a need for…

We present a new joint longitudinal and survival model aimed at estimating the association between the risk of an event and the change in and history of a biomarker that is repeatedly measured over time. We use cubic B-splines models for…

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…

Chikungunya is an emerging threat for health security all over the world which is spreading very fast. Researches for proper forecasting of the incidence rate of chikungunya has been going on in many places in which DARPA has done a very…

To combat the HIV/AIDS pandemic effectively, targeted interventions among certain key populations play a critical role. Examples of such key populations include sex workers, people who inject drugs, and men who have sex with men. While…

We consider a general mathematical model of a within-host viral infection with $n$ virus strains and explicit age-since-infection structure for infected cells. In the model, multiple virus strains compete for a population of target cells.…

Although combination antiretroviral therapy (ART) is highly effective in suppressing viral load for people with HIV (PWH), many ART agents may exacerbate central nervous system (CNS)-related adverse effects including depression. Therefore,…

We propose a model for the human immunodeficiency virus type 1 (HIV-1) infection with intracellular delay and prove the local asymptotical stability of the equilibrium points. Then we introduce a control function representing the efficiency…

Restrictions on social and economic activities, as well as vaccinations, have been a key intervention in containing the COVID-19 epidemic. Our work focuses on better understanding the options available to policymakers under the conditions…

This document provides the analytic plan for evaluating adult HIV incidence, health, and implementation outcomes for the first phase of the SEARCH Study. Locked: November 27, 2017. Embargoed until July 25, 2018.

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this…