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The emergence of a predominant phenotype within a cell population is often triggered by a rare accumulation of DNA mutations in a single cell. For example, tumors may be initiated by a single cell in which multiple mutations cooperate to…

Tissues and Organs · Quantitative Biology 2018-11-21 Philip Greulich , Benjamin D. Simons

Migrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow. Here we consider the effect of relatively recent population…

Populations and Evolution · Quantitative Biology 2012-04-26 Simon Gravel

In population genetics, extant samples are usually used for inference of past population genetic forces. With the Kingman coalescent and the backward diffusion equation, inference of the marginal likelihood proceeds from an extant sample…

Populations and Evolution · Quantitative Biology 2020-04-03 Claus Vogl , Sandra Peer

We consider the genealogy tree for a critical branching process conditioned on non-extinction. We enumerate vertices in each generation of the tree so that for each two generations one can define a monotone map describing the…

Probability · Mathematics 2010-08-27 Yuri Bakhtin

We investigate the infinitely many demes limit of the genealogy of a sample of individuals from a subdivided population subject to sporadic mass extinction events. By exploiting a separation of timescales property of Wright's island model,…

Probability · Mathematics 2009-01-29 Jesse E. Taylor , Amandine Veber

The sample frequency spectrum of a segregating site is the probability distribution of a sample of alleles from a genetic locus, conditional on observing the sample to have more than one clearly different phenotypes. We present a model for…

Probability · Mathematics 2014-05-13 Arka Bhattacharya

We consider a critical branching process in an i.i.d. random environment, in which one immigrant arrives at each generation. We are interested in the event $\mathcal{A}_i(n)$ that all individuals alive at time $n$ are offspring of the…

Probability · Mathematics 2019-11-04 Charline Smadi , Vladimir A. Vatutin

Coalescent processes, including mutation, are derived from Moran type population models admitting large offspring numbers. Including mutation in the coalescent process allows for quantifying the turnover of alleles by computing the…

Populations and Evolution · Quantitative Biology 2012-12-11 Bjarki Eldon

Branching processes are widely used to model phenomena from networks to neuronal avalanching. In a large class of continuous-time branching processes, we study the temporal scaling of the moments of the instant population size, the survival…

Statistical Mechanics · Physics 2018-12-18 Rosalba Garcia-Millan , Johannes Pausch , Benjamin Walter , Gunnar Pruessner

We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is decided at its birth and its remaining lifetime decreases at the unit speed. The models…

Probability · Mathematics 2024-01-08 Ziling Cheng , Zenghu Li

Assume that individuals alive at time $t$ in some population can be ranked in such a way that the coalescence times between consecutive individuals are i.i.d. The ranked sequence of these branches is called a coalescent point process. We…

Probability · Mathematics 2009-02-09 Amaury Lambert

Spatial models where growth is limited to the edge of the expansions have been instrumental to understand the population dynamics and the clone size distribution in growing cellular populations, such as microbial colonies and avascular…

Populations and Evolution · Quantitative Biology 2022-06-08 Armin Eghdami , Jayson Paulose , Diana Fusco

Large scale databases are available that contain homologous gene families constructed from hundreds of complete genome sequences from across the three domains of Life. Here we discuss approches of increasing complexity aimed at extracting…

Genomics · Quantitative Biology 2011-02-14 Gergely J Szöllősi , Vincent Daubin

A simplified model for the growth of a population is studied in which random effects arise because reproducing individuals have a certain probability of surviving until the next breeding season and hence contributing to the next generation.…

Populations and Evolution · Quantitative Biology 2016-04-05 Henry C. Tuckwell

A branching process in a Markovian environment consists of an irreducible Markov chain on a set of "environments" together with an offspring distribution for each environment. At each time step the chain transitions to a new random…

Probability · Mathematics 2021-06-22 Lila Greco , Lionel Levine

We consider a critical branching process $Y_{n}$ in an i.i.d. random environment, in which one immigrant arrives at each generation. Let $% \mathcal{A}_{i}(n)$ be the event that all individuals alive at time $n$ are offspring of the…

Probability · Mathematics 2022-08-17 Charline Smadi , Vladimir A. Vatutin

We present an elementary model of random size varying population given by a stationary continuous state branching process. For this model we compute the joint distribution of: the time to the most recent common ancestor, the size of the…

Probability · Mathematics 2010-09-07 Yu-Ting Chen , Jean-François Delmas

We investigate the genealogy of a sample of $k\geq1$ particles chosen uniformly without replacement from a population alive at large times in a critical discrete-time Galton-Watson process in a varying environment (GWVE). We will show that…

Probability · Mathematics 2024-03-04 Simon C. Harris , Sandra Palau , Juan Carlos Pardo

We consider the evolution of the genealogy of the population currently alive in a Feller branching diffusion model. In contrast to the approach via labeled trees in the continuum random tree world, the genealogies are modeled as equivalence…

Probability · Mathematics 2023-12-12 Andrej Depperschmidt , Andreas Greven

We consider a stochastic individual-based population model with competition, trait-structure affecting reproduction and survival, and changing environment. The changes of traits are described by jump processes, and the dynamics can be…

Probability · Mathematics 2022-01-17 Benoît Henry , Sylvie Méléard , Viet Chi Tran
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