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Machine learning classification systems are susceptible to poor performance when trained with incorrect ground truth labels, even when data is well-curated by expert annotators. As machine learning becomes more widespread, it is…

Machine Learning · Computer Science 2026-01-16 Zan Chaudhry , Noam H. Rotenberg , Brian Caffo , Craig K. Jones , Haris I. Sair

Biomedical datasets are often constrained by stringent privacy requirements and frequently suffer from severe class imbalance. These two aspects hinder the development of accurate machine learning models. While generative AI offers a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Jan Carreras Boada , Rao Muhammad Umer , Carsten Marr

In this paper, we introduce an unsupervised cancer segmentation framework for histology images. The framework involves an effective contrastive learning scheme for extracting distinctive visual representations for segmentation. The encoder…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Yilong Li , Yaqi Wang , Huiyu Zhou , Huaqiong Wang , Gangyong Jia , Qianni Zhang

Automated histopathological image analysis offers exciting opportunities for the early diagnosis of several medical conditions including cancer. There are however stiff practical challenges: 1.) discriminative features from such images for…

Image and Video Processing · Electrical Eng. & Systems 2017-12-25 Xuelu Li , Vishal Monga , U. K. Arvind Rao

The analysis of the tumor environment on digital histopathology slides is becoming key for the understanding of the immune response against cancer, supporting the development of novel immuno-therapies. We introduce here a novel deep…

Image and Video Processing · Electrical Eng. & Systems 2019-06-27 Ansh Kapil , Tobias Wiestler , Simon Lanzmich , Abraham Silva , Keith Steele , Marlon Rebelatto , Guenter Schmidt , Nicolas Brieu

Evaluating expression of the Human epidermal growth factor receptor 2 (Her2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognised…

We propose an exhaustive methodology that leverages all levels of feature abstraction, targeting an enhancement in the generalizability of image classification to unobserved hospitals. Our approach incorporates augmentation-based…

Computer Vision and Pattern Recognition · Computer Science 2023-08-10 Milad Sikaroudi , Maryam Hosseini , Shahryar Rahnamayan , H. R. Tizhoosh

Deep learning-based image generation has seen significant advancements with diffusion models, notably improving the quality of generated images. Despite these developments, generating images with unseen characteristics beneficial for…

Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences…

Image and Video Processing · Electrical Eng. & Systems 2022-08-03 Haseeb Nazki , Ognjen Arandjelović , InHwa Um , David Harrison

In recent years, computational pathology has seen tremendous progress driven by deep learning methods in segmentation and classification tasks aiding prognostic and diagnostic settings. Nuclei segmentation, for instance, is an important…

Image and Video Processing · Electrical Eng. & Systems 2023-03-22 Aman Shrivastava , P. Thomas Fletcher

Deep Neural Network (DNN) based point cloud semantic segmentation has presented significant achievements on large-scale labeled aerial laser point cloud datasets. However, annotating such large-scaled point clouds is time-consuming. Due to…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Yunsheng Zhang , Jianguo Yao , Ruixiang Zhang , Siyang Chen , Haifeng Li

Recent successes in learning-based image classification, however, heavily rely on the large number of annotated training samples, which may require considerable human efforts. In this paper, we propose a novel active learning framework,…

Computer Vision and Pattern Recognition · Computer Science 2017-01-16 Keze Wang , Dongyu Zhang , Ya Li , Ruimao Zhang , Liang Lin

Cell identification within the H&E slides is an essential prerequisite that can pave the way towards further pathology analyses including tissue classification, cancer grading, and phenotype prediction. However, performing such a task using…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Ramin Nakhli , Amirali Darbandsari , Hossein Farahani , Ali Bashashati

Label-free imaging has gained broad interest because of its potential to omit elaborate staining procedures which is especially relevant for in vivo use. Label-free multiphoton microscopy (MPM), for instance, exploits two-photon excitation…

The visual attributes of cells, such as the nuclear morphology and chromatin openness, are critical for histopathology image analysis. By learning cell-level visual representation, we can obtain a rich mix of features that are highly…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Bo Hu , Ye Tang , Eric I-Chao Chang , Yubo Fan , Maode Lai , Yan Xu

Predictive biomarkers of treatment response are lacking for metastatic clear cell renal cell carcinoma (ccRCC), a tumor type that is treated with angiogenesis inhibitors, immune checkpoint inhibitors, mTOR inhibitors and a HIF2 inhibitor.…

This paper proposes an unsupervised anomaly detection technique for image-based plant disease diagnosis. The construction of large and publicly available datasets containing labeled images of healthy and diseased crop plants led to growing…

Computer Vision and Pattern Recognition · Computer Science 2021-09-09 Ryoya Katafuchi , Terumasa Tokunaga

Artificial Intelligence (AI) based image analysis has an immense potential to support diagnostic histopathology, including cancer diagnostics. However, developing supervised AI methods requires large-scale annotated datasets. A potentially…

This paper presents an autoencoder-based neural network architecture to compress histopathological images while retaining the denser and more meaningful representation of the original images. Current research into improving compression…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Agnes Barsi , Suvendu Chandan Nayak , Sasmita Parida , Raj Mani Shukla

In this work, we tackle the challenging problem of arbitrary image style transfer using a novel style feature representation learning method. A suitable style representation, as a key component in image stylization tasks, is essential to…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yuxin Zhang , Fan Tang , Weiming Dong , Haibin Huang , Chongyang Ma , Tong-Yee Lee , Changsheng Xu